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Effects of tibolone and continuous combined hormone replacement therapy on parameters in the clotting cascade: a multicenter, double-blind, randomized study.
Fertil Steril. 2000 Jul; 74(1):10-9.FS

Abstract

OBJECTIVE

To determine the effects of tibolone and continuous combined HRT (ccHRT) on parameters in the clotting cascade.

DESIGN

Randomized, double-blind study.

SETTING

Hemostasis unit of a university hospital clinic in Germany.

PATIENT(S)

Sixty healthy postmenopausal women.

INTERVENTION(S)

Twenty-nine subjects were treated with tibolone (2.5 mg/d) and 31 with oral ccHRT containing estradiol (2 mg/d) + estriol (1 mg/d) + norethindrone acetate (1 mg/d).

MAIN OUTCOME MEASURE(S)

Effects on parameters in the clotting cascade at baseline and after 12 and 24 weeks of treatment.

RESULT(S)

Tibolone increased fibrinolysis parameters without significantly altering coagulation parameters. Treatment with ccHRT resulted in a stimulating effect on parameters of both fibrinolysis and coagulation. Tibolone showed a stronger reduction of factor VII activity; less reduction of AT-III, protein C activity, and protein S activity; stronger increase of the activated partial thromboplastin time, plasminogen and plasminogen-antiplasminogen complexes; and less increase of D-Dimer than ccHRT. Both preparations similarly reduced climacteric complaints, whereas tibolone showed less breast complaints than ccHRT.

CONCLUSION(S)

This study confirms that tibolone, and to a lesser extent also ccHRT, changes hemostasis parameters toward a more fibrinolytic profile, which may diminish the risk of venous thrombosis.

Authors+Show Affiliations

Hemostasis Unit, University Hospital of Essen, Germany. ulrich-horst.winkler@fek.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10899490

Citation

Winkler, U H., et al. "Effects of Tibolone and Continuous Combined Hormone Replacement Therapy On Parameters in the Clotting Cascade: a Multicenter, Double-blind, Randomized Study." Fertility and Sterility, vol. 74, no. 1, 2000, pp. 10-9.
Winkler UH, Altkemper R, Kwee B, et al. Effects of tibolone and continuous combined hormone replacement therapy on parameters in the clotting cascade: a multicenter, double-blind, randomized study. Fertil Steril. 2000;74(1):10-9.
Winkler, U. H., Altkemper, R., Kwee, B., Helmond, F. A., & Coelingh Bennink, H. J. (2000). Effects of tibolone and continuous combined hormone replacement therapy on parameters in the clotting cascade: a multicenter, double-blind, randomized study. Fertility and Sterility, 74(1), 10-9.
Winkler UH, et al. Effects of Tibolone and Continuous Combined Hormone Replacement Therapy On Parameters in the Clotting Cascade: a Multicenter, Double-blind, Randomized Study. Fertil Steril. 2000;74(1):10-9. PubMed PMID: 10899490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of tibolone and continuous combined hormone replacement therapy on parameters in the clotting cascade: a multicenter, double-blind, randomized study. AU - Winkler,U H, AU - Altkemper,R, AU - Kwee,B, AU - Helmond,F A, AU - Coelingh Bennink,H J, PY - 2000/7/19/pubmed PY - 2000/8/6/medline PY - 2000/7/19/entrez SP - 10 EP - 9 JF - Fertility and sterility JO - Fertil Steril VL - 74 IS - 1 N2 - OBJECTIVE: To determine the effects of tibolone and continuous combined HRT (ccHRT) on parameters in the clotting cascade. DESIGN: Randomized, double-blind study. SETTING: Hemostasis unit of a university hospital clinic in Germany. PATIENT(S): Sixty healthy postmenopausal women. INTERVENTION(S): Twenty-nine subjects were treated with tibolone (2.5 mg/d) and 31 with oral ccHRT containing estradiol (2 mg/d) + estriol (1 mg/d) + norethindrone acetate (1 mg/d). MAIN OUTCOME MEASURE(S): Effects on parameters in the clotting cascade at baseline and after 12 and 24 weeks of treatment. RESULT(S): Tibolone increased fibrinolysis parameters without significantly altering coagulation parameters. Treatment with ccHRT resulted in a stimulating effect on parameters of both fibrinolysis and coagulation. Tibolone showed a stronger reduction of factor VII activity; less reduction of AT-III, protein C activity, and protein S activity; stronger increase of the activated partial thromboplastin time, plasminogen and plasminogen-antiplasminogen complexes; and less increase of D-Dimer than ccHRT. Both preparations similarly reduced climacteric complaints, whereas tibolone showed less breast complaints than ccHRT. CONCLUSION(S): This study confirms that tibolone, and to a lesser extent also ccHRT, changes hemostasis parameters toward a more fibrinolytic profile, which may diminish the risk of venous thrombosis. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/10899490/Effects_of_tibolone_and_continuous_combined_hormone_replacement_therapy_on_parameters_in_the_clotting_cascade:_a_multicenter_double_blind_randomized_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(00)00587-2 DB - PRIME DP - Unbound Medicine ER -