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Histamine suppresses A-type potassium current in myenteric neurons from guinea pig small intestine.
J Pharmacol Exp Ther. 2000 Aug; 294(2):555-61.JP

Abstract

Perforated patch-clamp methods for recording ionic currents in the whole-cell configuration were used to test the hypothesis that the ionic mechanisms for the excitatory actions of histamine on enteric neurons include suppression of A-type K(+) current (I(A)). Histamine and the selective histamine H(2) receptor agonist, dimaprit, reduced the amplitude of I(A) without affecting the slope factor for I(A) steady-state inactivation curves. Suppression of I(A) was restricted to after hyperpolarization-type myenteric neurons that were immunoreactive for calbindin. The selective histamine H(2) receptor antagonist cimetidine suppressed the action of histamine and dimaprit. Elevation of intraneuronal cAMP by forskolin, a membrane-permeant analog of cAMP, and treatment with a phosphodiesterase inhibitor suppressed I(A.) The results are consistent with the hypothesis that suppression of I(A) is part of the ionic mechanism responsible for elevation of excitability during both slow synaptic excitation and slow synaptic excitation-like responses evoked by paracrine mediators, such as histamine, in after hyperpolarization-type myenteric neurons.

Authors+Show Affiliations

Department of Physiology and Cell Biology, College of Medicine and Public Health, The Ohio State University, Columbus 43211-1218, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10900232

Citation

Starodub, A M., and J D. Wood. "Histamine Suppresses A-type Potassium Current in Myenteric Neurons From Guinea Pig Small Intestine." The Journal of Pharmacology and Experimental Therapeutics, vol. 294, no. 2, 2000, pp. 555-61.
Starodub AM, Wood JD. Histamine suppresses A-type potassium current in myenteric neurons from guinea pig small intestine. J Pharmacol Exp Ther. 2000;294(2):555-61.
Starodub, A. M., & Wood, J. D. (2000). Histamine suppresses A-type potassium current in myenteric neurons from guinea pig small intestine. The Journal of Pharmacology and Experimental Therapeutics, 294(2), 555-61.
Starodub AM, Wood JD. Histamine Suppresses A-type Potassium Current in Myenteric Neurons From Guinea Pig Small Intestine. J Pharmacol Exp Ther. 2000;294(2):555-61. PubMed PMID: 10900232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histamine suppresses A-type potassium current in myenteric neurons from guinea pig small intestine. AU - Starodub,A M, AU - Wood,J D, PY - 2000/7/20/pubmed PY - 2000/8/29/medline PY - 2000/7/20/entrez SP - 555 EP - 61 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 294 IS - 2 N2 - Perforated patch-clamp methods for recording ionic currents in the whole-cell configuration were used to test the hypothesis that the ionic mechanisms for the excitatory actions of histamine on enteric neurons include suppression of A-type K(+) current (I(A)). Histamine and the selective histamine H(2) receptor agonist, dimaprit, reduced the amplitude of I(A) without affecting the slope factor for I(A) steady-state inactivation curves. Suppression of I(A) was restricted to after hyperpolarization-type myenteric neurons that were immunoreactive for calbindin. The selective histamine H(2) receptor antagonist cimetidine suppressed the action of histamine and dimaprit. Elevation of intraneuronal cAMP by forskolin, a membrane-permeant analog of cAMP, and treatment with a phosphodiesterase inhibitor suppressed I(A.) The results are consistent with the hypothesis that suppression of I(A) is part of the ionic mechanism responsible for elevation of excitability during both slow synaptic excitation and slow synaptic excitation-like responses evoked by paracrine mediators, such as histamine, in after hyperpolarization-type myenteric neurons. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/10900232/Histamine_suppresses_A_type_potassium_current_in_myenteric_neurons_from_guinea_pig_small_intestine_ L2 - https://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=10900232 DB - PRIME DP - Unbound Medicine ER -