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[Possible mechanisms of polyuria in progressive chronic renal failure].
Ter Arkh. 2000; 72(6):15-20.TA

Abstract

AIM

Elucidation of the role of saluresis and osmotic diuresis in renal function of patients with chronic renal failure.

MATERIAL AND METHODS

The trial included 68 subjects, among them 25 patients with chronic renal failure (CRF) of the third and fourth degree aged 16 to 72 years. Enzyme immunoassay was used to measure osmolality, sodium, potassium, magnesium, calcium and creatinine concentrations in the serum and urine as well as urine prostaglandin E2.

RESULTS

Renal function was studied in CRF patients with a 75-90% fall of glomerular filtration rate. Creatinine clearance was 19.9 +/- 0.96, it varied in different patients from 10.6 to 29.7 ml/min. It is shown that diuresis does not correlate with the total ion excretion (Na+ plus K+)(r = 0.946, p < 0.0001). A correlation was found between excretion of these ions and Mg2+ ions this indicating location of reabsorption reduction in the thick ascending limb of Henle loop. In CRF patients (Na+ plus K+) excretion correlated with PGE2 excretion (r = 0.65, p < 0.0001).

CONCLUSION

It is suggested that at this stage of chronic renal failure the mechanism of a diuresis increase is not due to osmotic diuresis but rather to secretion of prostaglandin E2 which inhibits cation reabsorption and stimulates diuresis. Differences are considered between osmotic diuresis and different types of saluresis; their possible mechanisms are discussed.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

rus

PubMed ID

10900642

Citation

Natochin, Iu V., and A E. Bogolepova. "[Possible Mechanisms of Polyuria in Progressive Chronic Renal Failure]." Terapevticheskii Arkhiv, vol. 72, no. 6, 2000, pp. 15-20.
Natochin IuV, Bogolepova AE. [Possible mechanisms of polyuria in progressive chronic renal failure]. Ter Arkh. 2000;72(6):15-20.
Natochin, I. u. V., & Bogolepova, A. E. (2000). [Possible mechanisms of polyuria in progressive chronic renal failure]. Terapevticheskii Arkhiv, 72(6), 15-20.
Natochin IuV, Bogolepova AE. [Possible Mechanisms of Polyuria in Progressive Chronic Renal Failure]. Ter Arkh. 2000;72(6):15-20. PubMed PMID: 10900642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Possible mechanisms of polyuria in progressive chronic renal failure]. AU - Natochin,Iu V, AU - Bogolepova,A E, PY - 2000/7/20/pubmed PY - 2000/8/19/medline PY - 2000/7/20/entrez SP - 15 EP - 20 JF - Terapevticheskii arkhiv JO - Ter Arkh VL - 72 IS - 6 N2 - AIM: Elucidation of the role of saluresis and osmotic diuresis in renal function of patients with chronic renal failure. MATERIAL AND METHODS: The trial included 68 subjects, among them 25 patients with chronic renal failure (CRF) of the third and fourth degree aged 16 to 72 years. Enzyme immunoassay was used to measure osmolality, sodium, potassium, magnesium, calcium and creatinine concentrations in the serum and urine as well as urine prostaglandin E2. RESULTS: Renal function was studied in CRF patients with a 75-90% fall of glomerular filtration rate. Creatinine clearance was 19.9 +/- 0.96, it varied in different patients from 10.6 to 29.7 ml/min. It is shown that diuresis does not correlate with the total ion excretion (Na+ plus K+)(r = 0.946, p < 0.0001). A correlation was found between excretion of these ions and Mg2+ ions this indicating location of reabsorption reduction in the thick ascending limb of Henle loop. In CRF patients (Na+ plus K+) excretion correlated with PGE2 excretion (r = 0.65, p < 0.0001). CONCLUSION: It is suggested that at this stage of chronic renal failure the mechanism of a diuresis increase is not due to osmotic diuresis but rather to secretion of prostaglandin E2 which inhibits cation reabsorption and stimulates diuresis. Differences are considered between osmotic diuresis and different types of saluresis; their possible mechanisms are discussed. SN - 0040-3660 UR - https://www.unboundmedicine.com/medline/citation/10900642/[Possible_mechanisms_of_polyuria_in_progressive_chronic_renal_failure]_ L2 - https://medlineplus.gov/kidneyfailure.html DB - PRIME DP - Unbound Medicine ER -