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The sign of Leser-Trélat in a case of adenocarcinoma of the lung.
J Am Acad Dermatol. 2000 Aug; 43(2 Pt 2):386-90.JA

Abstract

This is what we believe to be the first report of the sign of Leser-Trélat in association with occult adenocarcinoma of the lung. The sign of Leser-Trélat is proposed as a sign of possible occult malignancy, despite various suggestions to the contrary. Also, it is suggested that a tumor-produced humoral factor (eg, transforming growth factor-alpha [TGF-alpha]) could be responsible for both the acute eruption of the monomorphous seborrheic keratoses and the nearly concomitant development of acanthosis nigricans, which occurred in our case. The possible distinction between a hyperplastic and a neoplastic origin of various types of seborrheic keratosis is discussed in relation to this hypothetical humoral factor. In addition, we suggest a refinement of the definition of the sign of Leser-Trélat and discuss the use of "sign of Leser-Trélat" and "syndrome of Leser-Trélat" in relation to physical findings. All patients with the sign of Leser-Trélat should undergo a thorough evaluation for occult malignancy.

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Authors+Show Affiliations

Heaphy MR
Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
Millns JL
No affiliation info available
Schroeter AL
No affiliation info available

MeSH

Acanthosis NigricansAdenocarcinomaBiopsyFemaleHumansKeratosis, SeborrheicLung NeoplasmsMiddle AgedParaneoplastic SyndromesSkinTumor Necrosis Factor-alpha

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10901731

Citation

Heaphy, M R., et al. "The Sign of Leser-Trélat in a Case of Adenocarcinoma of the Lung." Journal of the American Academy of Dermatology, vol. 43, no. 2 Pt 2, 2000, pp. 386-90.
Heaphy MR, Millns JL, Schroeter AL. The sign of Leser-Trélat in a case of adenocarcinoma of the lung. J Am Acad Dermatol. 2000;43(2 Pt 2):386-90.
Heaphy, M. R., Millns, J. L., & Schroeter, A. L. (2000). The sign of Leser-Trélat in a case of adenocarcinoma of the lung. Journal of the American Academy of Dermatology, 43(2 Pt 2), 386-90.
Heaphy MR, Millns JL, Schroeter AL. The Sign of Leser-Trélat in a Case of Adenocarcinoma of the Lung. J Am Acad Dermatol. 2000;43(2 Pt 2):386-90. PubMed PMID: 10901731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The sign of Leser-Trélat in a case of adenocarcinoma of the lung. AU - Heaphy,M R,Jr AU - Millns,J L, AU - Schroeter,A L, PY - 2000/7/20/pubmed PY - 2000/8/29/medline PY - 2000/7/20/entrez SP - 386 EP - 90 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 43 IS - 2 Pt 2 N2 - This is what we believe to be the first report of the sign of Leser-Trélat in association with occult adenocarcinoma of the lung. The sign of Leser-Trélat is proposed as a sign of possible occult malignancy, despite various suggestions to the contrary. Also, it is suggested that a tumor-produced humoral factor (eg, transforming growth factor-alpha [TGF-alpha]) could be responsible for both the acute eruption of the monomorphous seborrheic keratoses and the nearly concomitant development of acanthosis nigricans, which occurred in our case. The possible distinction between a hyperplastic and a neoplastic origin of various types of seborrheic keratosis is discussed in relation to this hypothetical humoral factor. In addition, we suggest a refinement of the definition of the sign of Leser-Trélat and discuss the use of "sign of Leser-Trélat" and "syndrome of Leser-Trélat" in relation to physical findings. All patients with the sign of Leser-Trélat should undergo a thorough evaluation for occult malignancy. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/10901731/The_sign_of_Leser_Trélat_in_a_case_of_adenocarcinoma_of_the_lung_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(00)09052-6 DB - PRIME DP - Unbound Medicine ER -