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Postischemic recovery of heart metabolism and function: role of mitochondrial fatty acid transfer.
J Appl Physiol (1985). 2000 Jul; 89(1):111-9.JA

Abstract

Postischemic recovery of contractile function is better in hearts from fasted rats than in hearts from fed rats. In this study, we examined whether feeding-induced inhibition of palmitate oxidation at the level of carnitine palmitoyl transferase I is involved in the mechanism underlying impaired recovery of contractile function. Hearts isolated from fasted or fed rats were submitted to no-flow ischemia followed by reperfusion with buffer containing 8 mM glucose and either 0.4 mM palmitate or 0.8 mM octanoate. During reperfusion, oxidation of palmitate was higher after fasting than after feeding, whereas oxidation of octanoate was not influenced by the nutritional state. In the presence of palmitate, recovery of left ventricular developed pressure was better in hearts from fasted rats. Substitution of octanoate for palmitate during reperfusion enhanced recovery of left ventricular developed pressure in hearts from fed rats. However, the chain length of the fatty acid did not influence diastolic contracture. The results suggest that nutritional variation of mitochondrial fatty acid transfer may influence postischemic recovery of contractile function.

Authors+Show Affiliations

Cardiology Center, University Hospital of Geneva, CH-1211 Geneva 14, Switzerland. christophe.montessuit@hcuge.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10904042

Citation

Montessuit, C, et al. "Postischemic Recovery of Heart Metabolism and Function: Role of Mitochondrial Fatty Acid Transfer." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 89, no. 1, 2000, pp. 111-9.
Montessuit C, Papageorgiou I, Tardy-Cantalupi I, et al. Postischemic recovery of heart metabolism and function: role of mitochondrial fatty acid transfer. J Appl Physiol (1985). 2000;89(1):111-9.
Montessuit, C., Papageorgiou, I., Tardy-Cantalupi, I., Rosenblatt-Velin, N., & Lerch, R. (2000). Postischemic recovery of heart metabolism and function: role of mitochondrial fatty acid transfer. Journal of Applied Physiology (Bethesda, Md. : 1985), 89(1), 111-9.
Montessuit C, et al. Postischemic Recovery of Heart Metabolism and Function: Role of Mitochondrial Fatty Acid Transfer. J Appl Physiol (1985). 2000;89(1):111-9. PubMed PMID: 10904042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postischemic recovery of heart metabolism and function: role of mitochondrial fatty acid transfer. AU - Montessuit,C, AU - Papageorgiou,I, AU - Tardy-Cantalupi,I, AU - Rosenblatt-Velin,N, AU - Lerch,R, PY - 2000/7/25/pubmed PY - 2000/8/29/medline PY - 2000/7/25/entrez SP - 111 EP - 9 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J Appl Physiol (1985) VL - 89 IS - 1 N2 - Postischemic recovery of contractile function is better in hearts from fasted rats than in hearts from fed rats. In this study, we examined whether feeding-induced inhibition of palmitate oxidation at the level of carnitine palmitoyl transferase I is involved in the mechanism underlying impaired recovery of contractile function. Hearts isolated from fasted or fed rats were submitted to no-flow ischemia followed by reperfusion with buffer containing 8 mM glucose and either 0.4 mM palmitate or 0.8 mM octanoate. During reperfusion, oxidation of palmitate was higher after fasting than after feeding, whereas oxidation of octanoate was not influenced by the nutritional state. In the presence of palmitate, recovery of left ventricular developed pressure was better in hearts from fasted rats. Substitution of octanoate for palmitate during reperfusion enhanced recovery of left ventricular developed pressure in hearts from fed rats. However, the chain length of the fatty acid did not influence diastolic contracture. The results suggest that nutritional variation of mitochondrial fatty acid transfer may influence postischemic recovery of contractile function. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/10904042/Postischemic_recovery_of_heart_metabolism_and_function:_role_of_mitochondrial_fatty_acid_transfer_ L2 - https://journals.physiology.org/doi/10.1152/jappl.2000.89.1.111?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -