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A randomized trial of improved weight loss with a prepared meal plan in overweight and obese patients: impact on cardiovascular risk reduction.
Arch Intern Med 2000; 160(14):2150-8AI

Abstract

OBJECTIVE

To assess the long-term effects of a prepackaged, nutritionally complete, prepared meal plan compared with a usual-care diet (UCD) on weight loss and cardiovascular risk factors in overweight and obese persons.

DESIGN

In this randomized multicenter study, 302 persons with hypertension and dyslipidemia (n = 183) or with type 2 diabetes mellitus (n = 119) were randomized to the nutrient-fortified prepared meal plan (approximately 22% energy from fat, 58% from carbohydrate, and 20% from protein) or to a macronutrient-equivalent UCD.

MAIN OUTCOME MEASURES

The primary outcome measure was weight change. Secondary measures were changes in blood pressure or plasma lipid, lipoprotein, glucose, or glycosylated hemoglobin levels; quality of life; nutrient intake; and dietary compliance.

RESULTS

After 1 year, weight change in the hypertension/dyslipidemia group was -5.8+/-6.8 kg with the prepared meal plan vs -1.7+/-6.5 kg with the UCD plan (P<.001); for the type 2 diabetes mellitus group, the change was -3.0+/-5.4 kg with the prepared meal plan vs -1.0+/-3.8 kg with the UCD plan (P<.001) (data given as mean +/- SD). In both groups, both interventions improved blood pressure, total and low-density lipoprotein cholesterol levels, glycosylated hemoglobin level, and quality of life (P<.02); in the diabetic group, the glucose level was reduced (P<.001). Compared with those in the UCD group, participants with hypertension/dyslipidemia in the prepared meal plan group showed greater improvements in total (P<.01) and high-density lipoprotein (P<.03) cholesterol levels, systolic blood pressure (P<.03), and glucose level (P<.03); in participants with type 2 diabetes mellitus, there were greater improvements in glucose (P =.046) and glycosylated hemoglobin (P<.02) levels. The prepared meal plan group also showed greater improvements in quality of life (P<.05) and compliance (P<.001) than the UCD group.

CONCLUSIONS

Long-term dietary interventions induced significant weight loss and improved cardiovascular risk in high-risk patients. The prepared meal plan simultaneously provided the simplicity and nutrient composition necessary to maintain long-term compliance and to reduce cardiovascular risk.

Authors+Show Affiliations

Division of Nephrology, Hypertension, and Clinical Pharmacology, Suite 262, Oregon Health Sciences University, 3314 SW Veterans Hospital Rd, Portland, OR 97201-2940. metzj@ohsu.edu.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10904458

Citation

Metz, J A., et al. "A Randomized Trial of Improved Weight Loss With a Prepared Meal Plan in Overweight and Obese Patients: Impact On Cardiovascular Risk Reduction." Archives of Internal Medicine, vol. 160, no. 14, 2000, pp. 2150-8.
Metz JA, Stern JS, Kris-Etherton P, et al. A randomized trial of improved weight loss with a prepared meal plan in overweight and obese patients: impact on cardiovascular risk reduction. Arch Intern Med. 2000;160(14):2150-8.
Metz, J. A., Stern, J. S., Kris-Etherton, P., Reusser, M. E., Morris, C. D., Hatton, D. C., ... McCarron, D. A. (2000). A randomized trial of improved weight loss with a prepared meal plan in overweight and obese patients: impact on cardiovascular risk reduction. Archives of Internal Medicine, 160(14), pp. 2150-8.
Metz JA, et al. A Randomized Trial of Improved Weight Loss With a Prepared Meal Plan in Overweight and Obese Patients: Impact On Cardiovascular Risk Reduction. Arch Intern Med. 2000 Jul 24;160(14):2150-8. PubMed PMID: 10904458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized trial of improved weight loss with a prepared meal plan in overweight and obese patients: impact on cardiovascular risk reduction. AU - Metz,J A, AU - Stern,J S, AU - Kris-Etherton,P, AU - Reusser,M E, AU - Morris,C D, AU - Hatton,D C, AU - Oparil,S, AU - Haynes,R B, AU - Resnick,L M, AU - Pi-Sunyer,F X, AU - Clark,S, AU - Chester,L, AU - McMahon,M, AU - Snyder,G W, AU - McCarron,D A, PY - 2000/7/25/pubmed PY - 2000/8/12/medline PY - 2000/7/25/entrez SP - 2150 EP - 8 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 160 IS - 14 N2 - OBJECTIVE: To assess the long-term effects of a prepackaged, nutritionally complete, prepared meal plan compared with a usual-care diet (UCD) on weight loss and cardiovascular risk factors in overweight and obese persons. DESIGN: In this randomized multicenter study, 302 persons with hypertension and dyslipidemia (n = 183) or with type 2 diabetes mellitus (n = 119) were randomized to the nutrient-fortified prepared meal plan (approximately 22% energy from fat, 58% from carbohydrate, and 20% from protein) or to a macronutrient-equivalent UCD. MAIN OUTCOME MEASURES: The primary outcome measure was weight change. Secondary measures were changes in blood pressure or plasma lipid, lipoprotein, glucose, or glycosylated hemoglobin levels; quality of life; nutrient intake; and dietary compliance. RESULTS: After 1 year, weight change in the hypertension/dyslipidemia group was -5.8+/-6.8 kg with the prepared meal plan vs -1.7+/-6.5 kg with the UCD plan (P<.001); for the type 2 diabetes mellitus group, the change was -3.0+/-5.4 kg with the prepared meal plan vs -1.0+/-3.8 kg with the UCD plan (P<.001) (data given as mean +/- SD). In both groups, both interventions improved blood pressure, total and low-density lipoprotein cholesterol levels, glycosylated hemoglobin level, and quality of life (P<.02); in the diabetic group, the glucose level was reduced (P<.001). Compared with those in the UCD group, participants with hypertension/dyslipidemia in the prepared meal plan group showed greater improvements in total (P<.01) and high-density lipoprotein (P<.03) cholesterol levels, systolic blood pressure (P<.03), and glucose level (P<.03); in participants with type 2 diabetes mellitus, there were greater improvements in glucose (P =.046) and glycosylated hemoglobin (P<.02) levels. The prepared meal plan group also showed greater improvements in quality of life (P<.05) and compliance (P<.001) than the UCD group. CONCLUSIONS: Long-term dietary interventions induced significant weight loss and improved cardiovascular risk in high-risk patients. The prepared meal plan simultaneously provided the simplicity and nutrient composition necessary to maintain long-term compliance and to reduce cardiovascular risk. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/10904458/A_randomized_trial_of_improved_weight_loss_with_a_prepared_meal_plan_in_overweight_and_obese_patients:_impact_on_cardiovascular_risk_reduction_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/160/pg/2150 DB - PRIME DP - Unbound Medicine ER -