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A comparison of diabetic polyneuropathy in type II diabetic BBZDR/Wor rats and in type I diabetic BB/Wor rats.
Diabetologia 2000; 43(6):786-93D

Abstract

AIMS/HYPOTHESIS

To examine the functional, metabolic and structural abnormalities in peripheral nerve in the spontaneously Type II (non-insulin-dependent) diabetic BBZDR/Wor rat and compare these data with those in the Type I (insulin-dependent) diabetic BB/Wor rat.

METHODS

Animals were examined at 6 and 14 months of diabetes. Nerve conduction velocity was measured longitudinally. Nerve polyols were analysed using gas liquid chromatography and Na/K(+)-ATPase activity was measured enzymatically. Light and electron microscopic techniques were used for nerve morphometry.

RESULTS

Diabetic BBZDR/Wor rats showed a slowly progressive nerve conduction defect that reached 17% (p < 0.01) at 14 months. There was a decrease in Na+/K(+)-ATPase of 35% (p < 0.05). Structurally, there were mild myelinated fibre atrophy (p < 0.05), mild or absent changes of the node of Ranvier, but significant (p < 0.001) segmental demyelination and Wallerian degeneration. These findings point to a more severe nerve conduction defect, severe myelinated fibre atrophy and profound nodal changes in Type I spontaneously diabetic BB/Wor rats maintained at the same hyperglycaemic concentrations.

CONCLUSION/INTERPRETATION

We conclude that other factors, beside hyperglycaemia, are involved in the pathogenesis of the more severe Type I diabetic neuropathy which possibly involve insulin and C-peptide deficiencies.

Authors+Show Affiliations

Department of Pathology, Wayne State University, Detroit, Michigan 48201, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10907124

Citation

Sima, A A., et al. "A Comparison of Diabetic Polyneuropathy in Type II Diabetic BBZDR/Wor Rats and in Type I Diabetic BB/Wor Rats." Diabetologia, vol. 43, no. 6, 2000, pp. 786-93.
Sima AA, Zhang W, Xu G, et al. A comparison of diabetic polyneuropathy in type II diabetic BBZDR/Wor rats and in type I diabetic BB/Wor rats. Diabetologia. 2000;43(6):786-93.
Sima, A. A., Zhang, W., Xu, G., Sugimoto, K., Guberski, D., & Yorek, M. A. (2000). A comparison of diabetic polyneuropathy in type II diabetic BBZDR/Wor rats and in type I diabetic BB/Wor rats. Diabetologia, 43(6), pp. 786-93.
Sima AA, et al. A Comparison of Diabetic Polyneuropathy in Type II Diabetic BBZDR/Wor Rats and in Type I Diabetic BB/Wor Rats. Diabetologia. 2000;43(6):786-93. PubMed PMID: 10907124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of diabetic polyneuropathy in type II diabetic BBZDR/Wor rats and in type I diabetic BB/Wor rats. AU - Sima,A A, AU - Zhang,W, AU - Xu,G, AU - Sugimoto,K, AU - Guberski,D, AU - Yorek,M A, PY - 2000/7/25/pubmed PY - 2001/2/28/medline PY - 2000/7/25/entrez SP - 786 EP - 93 JF - Diabetologia JO - Diabetologia VL - 43 IS - 6 N2 - AIMS/HYPOTHESIS: To examine the functional, metabolic and structural abnormalities in peripheral nerve in the spontaneously Type II (non-insulin-dependent) diabetic BBZDR/Wor rat and compare these data with those in the Type I (insulin-dependent) diabetic BB/Wor rat. METHODS: Animals were examined at 6 and 14 months of diabetes. Nerve conduction velocity was measured longitudinally. Nerve polyols were analysed using gas liquid chromatography and Na/K(+)-ATPase activity was measured enzymatically. Light and electron microscopic techniques were used for nerve morphometry. RESULTS: Diabetic BBZDR/Wor rats showed a slowly progressive nerve conduction defect that reached 17% (p < 0.01) at 14 months. There was a decrease in Na+/K(+)-ATPase of 35% (p < 0.05). Structurally, there were mild myelinated fibre atrophy (p < 0.05), mild or absent changes of the node of Ranvier, but significant (p < 0.001) segmental demyelination and Wallerian degeneration. These findings point to a more severe nerve conduction defect, severe myelinated fibre atrophy and profound nodal changes in Type I spontaneously diabetic BB/Wor rats maintained at the same hyperglycaemic concentrations. CONCLUSION/INTERPRETATION: We conclude that other factors, beside hyperglycaemia, are involved in the pathogenesis of the more severe Type I diabetic neuropathy which possibly involve insulin and C-peptide deficiencies. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/10907124/A_comparison_of_diabetic_polyneuropathy_in_type_II_diabetic_BBZDR/Wor_rats_and_in_type_I_diabetic_BB/Wor_rats_ L2 - https://doi.org/10.1007/s001250051376 DB - PRIME DP - Unbound Medicine ER -