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Multivitamin use and mortality in a large prospective study.
Am J Epidemiol 2000; 152(2):149-62AJ

Abstract

To determine the relation between multivitamin use and death from heart disease, cerebrovascular disease, and cancer, the authors examined a prospective cohort of 1,063,023 adult Americans in 1982-1989 and compared the mortality of users of multivitamins alone; vitamin A, C, or E alone; and multivitamin and vitamin A, C, or E in combination with that of vitamin nonusers by using multivariate Cox proportional hazard models. Multivitamin users had heart disease and cerebrovascular disease mortality risks similar to those of nonusers, whereas combination users had mortality risks that were 15% lower than those of nonusers. Multivitamin and combination use had minimal effect on cancer mortality overall, although mortality from all cancers combined was increased among male current smokers who used multivitamins alone (relative risk (RR) = 1.13, 95% confidence interval (CI): 1.05, 1.23) or in combination with vitamin A, C, or E (RR = 1.16, 95% CI: 1.06, 1.26), but decreased in male combination users who had never (RR = 0.86, 95% CI: 0.74, 0.99) or had formerly (RR = 0.90, 95% CI: 0.82, 0.98) smoked. No such associations were seen in women. These observational data provide limited support for the hypothesis that multivitamin use in combination with vitamin A, C, or E may reduce heart disease and cardiovascular disease mortality, but add to concerns raised by randomized studies that some vitamin supplements may adversely affect male smokers.

Authors+Show Affiliations

Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Birth Defects, Child Development, Disability and Health, Birth Defects and Pediatric Genetics Branch, Atlanta, GA 30341-3717, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10909952

Citation

Watkins, M L., et al. "Multivitamin Use and Mortality in a Large Prospective Study." American Journal of Epidemiology, vol. 152, no. 2, 2000, pp. 149-62.
Watkins ML, Erickson JD, Thun MJ, et al. Multivitamin use and mortality in a large prospective study. Am J Epidemiol. 2000;152(2):149-62.
Watkins, M. L., Erickson, J. D., Thun, M. J., Mulinare, J., & Heath, C. W. (2000). Multivitamin use and mortality in a large prospective study. American Journal of Epidemiology, 152(2), pp. 149-62.
Watkins ML, et al. Multivitamin Use and Mortality in a Large Prospective Study. Am J Epidemiol. 2000 Jul 15;152(2):149-62. PubMed PMID: 10909952.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multivitamin use and mortality in a large prospective study. AU - Watkins,M L, AU - Erickson,J D, AU - Thun,M J, AU - Mulinare,J, AU - Heath,C W,Jr PY - 2000/7/26/pubmed PY - 2000/8/6/medline PY - 2000/7/26/entrez SP - 149 EP - 62 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 152 IS - 2 N2 - To determine the relation between multivitamin use and death from heart disease, cerebrovascular disease, and cancer, the authors examined a prospective cohort of 1,063,023 adult Americans in 1982-1989 and compared the mortality of users of multivitamins alone; vitamin A, C, or E alone; and multivitamin and vitamin A, C, or E in combination with that of vitamin nonusers by using multivariate Cox proportional hazard models. Multivitamin users had heart disease and cerebrovascular disease mortality risks similar to those of nonusers, whereas combination users had mortality risks that were 15% lower than those of nonusers. Multivitamin and combination use had minimal effect on cancer mortality overall, although mortality from all cancers combined was increased among male current smokers who used multivitamins alone (relative risk (RR) = 1.13, 95% confidence interval (CI): 1.05, 1.23) or in combination with vitamin A, C, or E (RR = 1.16, 95% CI: 1.06, 1.26), but decreased in male combination users who had never (RR = 0.86, 95% CI: 0.74, 0.99) or had formerly (RR = 0.90, 95% CI: 0.82, 0.98) smoked. No such associations were seen in women. These observational data provide limited support for the hypothesis that multivitamin use in combination with vitamin A, C, or E may reduce heart disease and cardiovascular disease mortality, but add to concerns raised by randomized studies that some vitamin supplements may adversely affect male smokers. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/10909952/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/152.2.149 DB - PRIME DP - Unbound Medicine ER -