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Localization of heme oxygenase-2 and modulation of cGMP levels by carbon monoxide and/or nitric oxide in the retina.
Vis Neurosci. 2000 May-Jun; 17(3):319-29.VN

Abstract

Heme oxygenase-2 (HO-2) synthesizes carbon monoxide (CO), a modulator of soluble guanylate cyclase (sGC). To examine this signal transduction pathway in the retina, we immunocytochemically localized HO-2, and investigated the effects of CO on cGMP levels. In turtle, HO-2-like immunoreactivity (-LI) was in all photoreceptors, some amacrine cells, and in numerous bipolar and ganglion cells. HO-2-LI colocalized with sGC activity in many cells. In rat, HO-LI was found only in the inner retina, in ganglion and amacrine cells. In turtle, stimulation with CO alone primarily increased cGMP-LI in bipolar cells in the visual streak. Stimulation with a combination of CO and nitric oxide (NO) dramatically increased cGMP-LI throughout the retina, in comparison to the smaller increases seen with NO or CO alone. These data suggest that CO is an endogenous modulator of the sGC/cGMP signaling pathway in many retinal neurons, and can dramatically amplify NO-stimulated increases in cGMP.

Authors+Show Affiliations

Department of Biology, Boston University, MA 02215, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10910101

Citation

Cao, L, et al. "Localization of Heme Oxygenase-2 and Modulation of cGMP Levels By Carbon Monoxide And/or Nitric Oxide in the Retina." Visual Neuroscience, vol. 17, no. 3, 2000, pp. 319-29.
Cao L, Blute TA, Eldred WD. Localization of heme oxygenase-2 and modulation of cGMP levels by carbon monoxide and/or nitric oxide in the retina. Vis Neurosci. 2000;17(3):319-29.
Cao, L., Blute, T. A., & Eldred, W. D. (2000). Localization of heme oxygenase-2 and modulation of cGMP levels by carbon monoxide and/or nitric oxide in the retina. Visual Neuroscience, 17(3), 319-29.
Cao L, Blute TA, Eldred WD. Localization of Heme Oxygenase-2 and Modulation of cGMP Levels By Carbon Monoxide And/or Nitric Oxide in the Retina. Vis Neurosci. 2000 May-Jun;17(3):319-29. PubMed PMID: 10910101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Localization of heme oxygenase-2 and modulation of cGMP levels by carbon monoxide and/or nitric oxide in the retina. AU - Cao,L, AU - Blute,T A, AU - Eldred,W D, PY - 2000/7/26/pubmed PY - 2001/2/28/medline PY - 2000/7/26/entrez SP - 319 EP - 29 JF - Visual neuroscience JO - Vis Neurosci VL - 17 IS - 3 N2 - Heme oxygenase-2 (HO-2) synthesizes carbon monoxide (CO), a modulator of soluble guanylate cyclase (sGC). To examine this signal transduction pathway in the retina, we immunocytochemically localized HO-2, and investigated the effects of CO on cGMP levels. In turtle, HO-2-like immunoreactivity (-LI) was in all photoreceptors, some amacrine cells, and in numerous bipolar and ganglion cells. HO-2-LI colocalized with sGC activity in many cells. In rat, HO-LI was found only in the inner retina, in ganglion and amacrine cells. In turtle, stimulation with CO alone primarily increased cGMP-LI in bipolar cells in the visual streak. Stimulation with a combination of CO and nitric oxide (NO) dramatically increased cGMP-LI throughout the retina, in comparison to the smaller increases seen with NO or CO alone. These data suggest that CO is an endogenous modulator of the sGC/cGMP signaling pathway in many retinal neurons, and can dramatically amplify NO-stimulated increases in cGMP. SN - 0952-5238 UR - https://www.unboundmedicine.com/medline/citation/10910101/Localization_of_heme_oxygenase_2_and_modulation_of_cGMP_levels_by_carbon_monoxide_and/or_nitric_oxide_in_the_retina_ L2 - https://www.cambridge.org/core/product/identifier/S0952523800173018/type/journal_article DB - PRIME DP - Unbound Medicine ER -