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Coffee consumption, rheumatoid factor, and the risk of rheumatoid arthritis.
Ann Rheum Dis. 2000 Aug; 59(8):631-5.AR

Abstract

BACKGROUND

Recent epidemiological studies have suggested that smoking is a risk factor for rheumatoid factor (RF) positive rheumatoid arthritis (RA). Being overweight, high serum cholesterol, and dietary factors have in some studies been found to be associated with the risk of RA. No attention, however, has been paid to coffee consumption as a risk determinant, though it is a shared covariate of the alleged risk factors.

OBJECTIVES

This study aimed at examining coffee consumption for its associations with RF positivity and with the risk of RA.

METHODS

Coffee consumption was studied, firstly, for its association with RF (sensitised sheep cell agglutination titre >/=128) in a cross sectional survey of 6809 subjects with no clinical arthritis, and secondly, for its prediction of RA in a cohort of 18 981 men and women who had neither arthritis nor a history of it at the baseline examination in 1973-76. Up to late 1989, 126 subjects of the cohort study had developed RA, of whom, 89 were positive for RF by the time of diagnosis.

RESULTS

In the cross sectional survey the number of cups of coffee drunk daily was directly proportional to the prevalence of RF positivity. Adjusted for age and sex this association was significant (p value for linear trend, 0.008), but after further adjustment for smoking the linear trend declined below significance (p=0.06). In the cohort study there was an association between coffee consumption and the risk of RF positive RA that was not due to age, sex, level of education, smoking, alcohol intake, body mass index, or serum cholesterol. After adjustment for these potential confounders the users of four or more cups a day still had a relative risk of 2.20 (95% confidence interval 1.13 to 4.27) for developing RF positive RA compared with those drinking less. Coffee consumption did not predict the development of RF negative RA.

CONCLUSION

Coffee consumption may be a risk factor for RA, possibly through mechanisms contributing to the production of RF. This hypothesis remains to be tested in further studies.

Authors+Show Affiliations

National Public Health Institute, Helsinki, Finland. markku.heliovaara@ktl.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10913061

Citation

Heliövaara, M, et al. "Coffee Consumption, Rheumatoid Factor, and the Risk of Rheumatoid Arthritis." Annals of the Rheumatic Diseases, vol. 59, no. 8, 2000, pp. 631-5.
Heliövaara M, Aho K, Knekt P, et al. Coffee consumption, rheumatoid factor, and the risk of rheumatoid arthritis. Ann Rheum Dis. 2000;59(8):631-5.
Heliövaara, M., Aho, K., Knekt, P., Impivaara, O., Reunanen, A., & Aromaa, A. (2000). Coffee consumption, rheumatoid factor, and the risk of rheumatoid arthritis. Annals of the Rheumatic Diseases, 59(8), 631-5.
Heliövaara M, et al. Coffee Consumption, Rheumatoid Factor, and the Risk of Rheumatoid Arthritis. Ann Rheum Dis. 2000;59(8):631-5. PubMed PMID: 10913061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee consumption, rheumatoid factor, and the risk of rheumatoid arthritis. AU - Heliövaara,M, AU - Aho,K, AU - Knekt,P, AU - Impivaara,O, AU - Reunanen,A, AU - Aromaa,A, PY - 2000/7/27/pubmed PY - 2000/9/19/medline PY - 2000/7/27/entrez SP - 631 EP - 5 JF - Annals of the rheumatic diseases JO - Ann Rheum Dis VL - 59 IS - 8 N2 - BACKGROUND: Recent epidemiological studies have suggested that smoking is a risk factor for rheumatoid factor (RF) positive rheumatoid arthritis (RA). Being overweight, high serum cholesterol, and dietary factors have in some studies been found to be associated with the risk of RA. No attention, however, has been paid to coffee consumption as a risk determinant, though it is a shared covariate of the alleged risk factors. OBJECTIVES: This study aimed at examining coffee consumption for its associations with RF positivity and with the risk of RA. METHODS: Coffee consumption was studied, firstly, for its association with RF (sensitised sheep cell agglutination titre >/=128) in a cross sectional survey of 6809 subjects with no clinical arthritis, and secondly, for its prediction of RA in a cohort of 18 981 men and women who had neither arthritis nor a history of it at the baseline examination in 1973-76. Up to late 1989, 126 subjects of the cohort study had developed RA, of whom, 89 were positive for RF by the time of diagnosis. RESULTS: In the cross sectional survey the number of cups of coffee drunk daily was directly proportional to the prevalence of RF positivity. Adjusted for age and sex this association was significant (p value for linear trend, 0.008), but after further adjustment for smoking the linear trend declined below significance (p=0.06). In the cohort study there was an association between coffee consumption and the risk of RF positive RA that was not due to age, sex, level of education, smoking, alcohol intake, body mass index, or serum cholesterol. After adjustment for these potential confounders the users of four or more cups a day still had a relative risk of 2.20 (95% confidence interval 1.13 to 4.27) for developing RF positive RA compared with those drinking less. Coffee consumption did not predict the development of RF negative RA. CONCLUSION: Coffee consumption may be a risk factor for RA, possibly through mechanisms contributing to the production of RF. This hypothesis remains to be tested in further studies. SN - 0003-4967 UR - https://www.unboundmedicine.com/medline/citation/10913061/Coffee_consumption_rheumatoid_factor_and_the_risk_of_rheumatoid_arthritis_ L2 - https://ard.bmj.com/lookup/pmidlookup?view=long&pmid=10913061 DB - PRIME DP - Unbound Medicine ER -