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Effect of supplementation of arachidonic acid (AA) or a combination of AA plus docosahexaenoic acid on breastmilk fatty acid composition.

Abstract

We investigated whether supplementation with arachidonic acid (20:4 omega 6; AA), or a combination of AA and docosahexaenoic acid (22:6 omega 3; DHA) would affect human milk polyunsaturated fatty acid (PUFA) composition. Ten women were daily supplemented with 300 mg AA, eight with 300 mg AA, 110 mg eicosapentaenoic acid (20:5 omega 3; EPA) and 400 mg DHA, for one week and eight women served as unsupplemented controls. Milk samples were collected on days 0, 1 and 7. The fatty acid composition of the milk was analyzed by capillary gas chromatography with flame ionisation detection. Supplementation with AA alone had no effect on breastmilk AA, but tended to reduce EPA and DHA levels. Administration of a combination of AA, EPA and DHA tended to increase both milk AA and long chain PUFA (LCPUFA)omega 3 content. A larger simultaneous increase of milk AA, DHA and EPA than observed in the present study can probably be accomplished by the use of a combination of a lower LCPUFA omega 6/LCPUFA omega 3 ratio and higher AA, EPA and DHA dosages.

Authors+Show Affiliations

Departments of Obstetrics/Pediatrics, University Hospital Groningen, The Netherlands. e.r.boersma@med.rug.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10913225

Citation

Smit, E N., et al. "Effect of Supplementation of Arachidonic Acid (AA) or a Combination of AA Plus Docosahexaenoic Acid On Breastmilk Fatty Acid Composition." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 62, no. 6, 2000, pp. 335-40.
Smit EN, Koopmann M, Boersma ER, et al. Effect of supplementation of arachidonic acid (AA) or a combination of AA plus docosahexaenoic acid on breastmilk fatty acid composition. Prostaglandins Leukot Essent Fatty Acids. 2000;62(6):335-40.
Smit, E. N., Koopmann, M., Boersma, E. R., & Muskiet, F. A. (2000). Effect of supplementation of arachidonic acid (AA) or a combination of AA plus docosahexaenoic acid on breastmilk fatty acid composition. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 62(6), pp. 335-40.
Smit EN, et al. Effect of Supplementation of Arachidonic Acid (AA) or a Combination of AA Plus Docosahexaenoic Acid On Breastmilk Fatty Acid Composition. Prostaglandins Leukot Essent Fatty Acids. 2000;62(6):335-40. PubMed PMID: 10913225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of supplementation of arachidonic acid (AA) or a combination of AA plus docosahexaenoic acid on breastmilk fatty acid composition. AU - Smit,E N, AU - Koopmann,M, AU - Boersma,E R, AU - Muskiet,F A, PY - 2000/7/27/pubmed PY - 2000/9/9/medline PY - 2000/7/27/entrez SP - 335 EP - 40 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 62 IS - 6 N2 - We investigated whether supplementation with arachidonic acid (20:4 omega 6; AA), or a combination of AA and docosahexaenoic acid (22:6 omega 3; DHA) would affect human milk polyunsaturated fatty acid (PUFA) composition. Ten women were daily supplemented with 300 mg AA, eight with 300 mg AA, 110 mg eicosapentaenoic acid (20:5 omega 3; EPA) and 400 mg DHA, for one week and eight women served as unsupplemented controls. Milk samples were collected on days 0, 1 and 7. The fatty acid composition of the milk was analyzed by capillary gas chromatography with flame ionisation detection. Supplementation with AA alone had no effect on breastmilk AA, but tended to reduce EPA and DHA levels. Administration of a combination of AA, EPA and DHA tended to increase both milk AA and long chain PUFA (LCPUFA)omega 3 content. A larger simultaneous increase of milk AA, DHA and EPA than observed in the present study can probably be accomplished by the use of a combination of a lower LCPUFA omega 6/LCPUFA omega 3 ratio and higher AA, EPA and DHA dosages. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/10913225/Effect_of_supplementation_of_arachidonic_acid__AA__or_a_combination_of_AA_plus_docosahexaenoic_acid_on_breastmilk_fatty_acid_composition_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(00)90163-7 DB - PRIME DP - Unbound Medicine ER -