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Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae.
Clin Infect Dis. 2000 Jul; 31(1):80-4.CI

Abstract

To evaluate the spectrum and regulation of matrix metalloproteinases (MMPs) in bacterial meningitis (BM), concentrations of MMP-2, MMP-3, MMP-8, and MMP-9 and endogenous inhibitors of metalloproteinases (TIMP-1 and TIMP-2) were measured in the cerebrospinal fluid (CSF) of 27 children with BM. MMP-8 and MMP-9 were detected in 91% and 97%, respectively, of CSF specimens from patients but were not detected in control patients. CSF levels of MMP-9 were higher (P<.05) in 5 patients who developed hearing impairment or secondary epilepsy than in those who recovered without neurological deficits. Levels of MMP-9 correlated with concentrations of TIMP-1 (P<.001) and tumor necrosis factor-alpha (P=.03). Repeated lumbar punctures showed that levels of MMP-8 and MMP-9 were regulated independently and did not correlate with the CSF cell count. Therefore, MMPs may derive not only from granulocytes infiltrating the CSF space but also from parenchymal cells of the meninges and brain. High concentrations of MMP-9 are a risk factor for the development of postmeningitidal neurological sequelae.

Authors+Show Affiliations

Departments of Research and Neurology, University Hospitals, CH-4031 Basel, Switzerland. David.Leppert@.unibas.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10913401

Citation

Leppert, D, et al. "Matrix Metalloproteinase (MMP)-8 and MMP-9 in Cerebrospinal Fluid During Bacterial Meningitis: Association With Blood-brain Barrier Damage and Neurological Sequelae." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 31, no. 1, 2000, pp. 80-4.
Leppert D, Leib SL, Grygar C, et al. Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae. Clin Infect Dis. 2000;31(1):80-4.
Leppert, D., Leib, S. L., Grygar, C., Miller, K. M., Schaad, U. B., & Holländer, G. A. (2000). Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 31(1), 80-4.
Leppert D, et al. Matrix Metalloproteinase (MMP)-8 and MMP-9 in Cerebrospinal Fluid During Bacterial Meningitis: Association With Blood-brain Barrier Damage and Neurological Sequelae. Clin Infect Dis. 2000;31(1):80-4. PubMed PMID: 10913401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae. AU - Leppert,D, AU - Leib,S L, AU - Grygar,C, AU - Miller,K M, AU - Schaad,U B, AU - Holländer,G A, Y1 - 2000/07/14/ PY - 1999/09/07/received PY - 1999/12/22/revised PY - 2000/7/29/pubmed PY - 2001/2/28/medline PY - 2000/7/29/entrez SP - 80 EP - 4 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 31 IS - 1 N2 - To evaluate the spectrum and regulation of matrix metalloproteinases (MMPs) in bacterial meningitis (BM), concentrations of MMP-2, MMP-3, MMP-8, and MMP-9 and endogenous inhibitors of metalloproteinases (TIMP-1 and TIMP-2) were measured in the cerebrospinal fluid (CSF) of 27 children with BM. MMP-8 and MMP-9 were detected in 91% and 97%, respectively, of CSF specimens from patients but were not detected in control patients. CSF levels of MMP-9 were higher (P<.05) in 5 patients who developed hearing impairment or secondary epilepsy than in those who recovered without neurological deficits. Levels of MMP-9 correlated with concentrations of TIMP-1 (P<.001) and tumor necrosis factor-alpha (P=.03). Repeated lumbar punctures showed that levels of MMP-8 and MMP-9 were regulated independently and did not correlate with the CSF cell count. Therefore, MMPs may derive not only from granulocytes infiltrating the CSF space but also from parenchymal cells of the meninges and brain. High concentrations of MMP-9 are a risk factor for the development of postmeningitidal neurological sequelae. SN - 1058-4838 UR - https://www.unboundmedicine.com/medline/citation/10913401/Matrix_metalloproteinase__MMP__8_and_MMP_9_in_cerebrospinal_fluid_during_bacterial_meningitis:_association_with_blood_brain_barrier_damage_and_neurological_sequelae_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/313922 DB - PRIME DP - Unbound Medicine ER -