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Enhancement of dissolution and bioavailability of piroxicam in solid dispersion systems.
Drug Dev Ind Pharm. 2000 Sep; 26(9):989-94.DD

Abstract

Solid dispersion systems of water-insoluble piroxicam in polyethylene glycol (PEG) 4000 and in urea were prepared by fusion and solvent methods and were characterized in this study. The in vitro dissolution studies showed that the dispersion systems containing piroxicam and PEG4000 or urea gave faster dissolution than the corresponding simple mixtures. The differential scanning calorimetry (DSC) study indicated that the piroxicam-PEG system prepared by the fusion method is a solid dispersion, while the piroxicam-urea system prepared by the solvent method is likely to be a solid solution of piroxicam in urea. The storage testings showed that all dispersions were stable, except that uptake of water during storage may occur in the PEG system. A single-dose study with rabbits showed that the dispersion systems provided statistically significant to a higher extent and rate of bioavailability than the corresponding physical mixture (p < 0.05).

Authors+Show Affiliations

School of Pharmacy, College of Medicine, National Taiwan University, Republic of China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10914324

Citation

Pan, R N., et al. "Enhancement of Dissolution and Bioavailability of Piroxicam in Solid Dispersion Systems." Drug Development and Industrial Pharmacy, vol. 26, no. 9, 2000, pp. 989-94.
Pan RN, Chen JH, Chen RR. Enhancement of dissolution and bioavailability of piroxicam in solid dispersion systems. Drug Dev Ind Pharm. 2000;26(9):989-94.
Pan, R. N., Chen, J. H., & Chen, R. R. (2000). Enhancement of dissolution and bioavailability of piroxicam in solid dispersion systems. Drug Development and Industrial Pharmacy, 26(9), 989-94.
Pan RN, Chen JH, Chen RR. Enhancement of Dissolution and Bioavailability of Piroxicam in Solid Dispersion Systems. Drug Dev Ind Pharm. 2000;26(9):989-94. PubMed PMID: 10914324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhancement of dissolution and bioavailability of piroxicam in solid dispersion systems. AU - Pan,R N, AU - Chen,J H, AU - Chen,R R, PY - 2000/7/29/pubmed PY - 2001/2/28/medline PY - 2000/7/29/entrez SP - 989 EP - 94 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 26 IS - 9 N2 - Solid dispersion systems of water-insoluble piroxicam in polyethylene glycol (PEG) 4000 and in urea were prepared by fusion and solvent methods and were characterized in this study. The in vitro dissolution studies showed that the dispersion systems containing piroxicam and PEG4000 or urea gave faster dissolution than the corresponding simple mixtures. The differential scanning calorimetry (DSC) study indicated that the piroxicam-PEG system prepared by the fusion method is a solid dispersion, while the piroxicam-urea system prepared by the solvent method is likely to be a solid solution of piroxicam in urea. The storage testings showed that all dispersions were stable, except that uptake of water during storage may occur in the PEG system. A single-dose study with rabbits showed that the dispersion systems provided statistically significant to a higher extent and rate of bioavailability than the corresponding physical mixture (p < 0.05). SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/10914324/Enhancement_of_dissolution_and_bioavailability_of_piroxicam_in_solid_dispersion_systems_ L2 - https://www.tandfonline.com/doi/full/10.1081/ddc-100101327 DB - PRIME DP - Unbound Medicine ER -