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A randomized controlled trial to evaluate the effectiveness of an exercise program in women with rheumatoid arthritis taking low dose prednisone.
J Rheumatol. 2000 Jul; 27(7):1674-80.JR

Abstract

OBJECTIVE

To evaluate the effects of a 12 month, weight bearing, aerobic exercise program on disease activity, physical function, and bone mineral density (BMD) in women with rheumatoid arthritis (RA) taking low dose prednisone.

METHODS

A group of women with RA (n = 23) not receiving steroid therapy and in American College of Rheumatology functional class I or II was compared to 30 steroid treated patients with similar demographics. The latter group was randomized to usual care (n = 16) or an aerobic, weight bearing exercise program (n = 14) 3 times a week for 12 months. All subjects were recruited from an outpatient rheumatology clinic or physical therapy department and met the study inclusion criteria. Outcome measures included disease activity (erythrocyte sedimentation rate, active joint count), physical function (Health Assessment Questionnaire disability index, activity level) and BMD of the spine and femoral neck (by dual energy projection radiology).

RESULTS

Subjects in the exercise group had a small but nonsignificant decrease in disease activity and statistically significant improvements in function (p = 0.05) and activity levels (p = 0.05). BMD remained unchanged in the exercise group, decreased significantly (p = 0.004) in the nonsteroid comparison group (hip), and changed nonsignificantly in the control group. However, between-group changes in spinal BMD of the steroid treated groups was not significant (p = 0.09).

CONCLUSION

Women with RA taking low dose steroid therapy can safely participate in a dynamic, weight bearing exercise program with positive effects on their physical function, activity and fitness levels, and BMD with no exacerbation of disease activity.

Authors+Show Affiliations

Physical Therapy Department, Vancouver Hospital and Health Sciences Centre, British, Columbia, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10914850

Citation

Westby, M D., et al. "A Randomized Controlled Trial to Evaluate the Effectiveness of an Exercise Program in Women With Rheumatoid Arthritis Taking Low Dose Prednisone." The Journal of Rheumatology, vol. 27, no. 7, 2000, pp. 1674-80.
Westby MD, Wade JP, Rangno KK, et al. A randomized controlled trial to evaluate the effectiveness of an exercise program in women with rheumatoid arthritis taking low dose prednisone. J Rheumatol. 2000;27(7):1674-80.
Westby, M. D., Wade, J. P., Rangno, K. K., & Berkowitz, J. (2000). A randomized controlled trial to evaluate the effectiveness of an exercise program in women with rheumatoid arthritis taking low dose prednisone. The Journal of Rheumatology, 27(7), 1674-80.
Westby MD, et al. A Randomized Controlled Trial to Evaluate the Effectiveness of an Exercise Program in Women With Rheumatoid Arthritis Taking Low Dose Prednisone. J Rheumatol. 2000;27(7):1674-80. PubMed PMID: 10914850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized controlled trial to evaluate the effectiveness of an exercise program in women with rheumatoid arthritis taking low dose prednisone. AU - Westby,M D, AU - Wade,J P, AU - Rangno,K K, AU - Berkowitz,J, PY - 2000/7/29/pubmed PY - 2001/2/28/medline PY - 2000/7/29/entrez SP - 1674 EP - 80 JF - The Journal of rheumatology JO - J Rheumatol VL - 27 IS - 7 N2 - OBJECTIVE: To evaluate the effects of a 12 month, weight bearing, aerobic exercise program on disease activity, physical function, and bone mineral density (BMD) in women with rheumatoid arthritis (RA) taking low dose prednisone. METHODS: A group of women with RA (n = 23) not receiving steroid therapy and in American College of Rheumatology functional class I or II was compared to 30 steroid treated patients with similar demographics. The latter group was randomized to usual care (n = 16) or an aerobic, weight bearing exercise program (n = 14) 3 times a week for 12 months. All subjects were recruited from an outpatient rheumatology clinic or physical therapy department and met the study inclusion criteria. Outcome measures included disease activity (erythrocyte sedimentation rate, active joint count), physical function (Health Assessment Questionnaire disability index, activity level) and BMD of the spine and femoral neck (by dual energy projection radiology). RESULTS: Subjects in the exercise group had a small but nonsignificant decrease in disease activity and statistically significant improvements in function (p = 0.05) and activity levels (p = 0.05). BMD remained unchanged in the exercise group, decreased significantly (p = 0.004) in the nonsteroid comparison group (hip), and changed nonsignificantly in the control group. However, between-group changes in spinal BMD of the steroid treated groups was not significant (p = 0.09). CONCLUSION: Women with RA taking low dose steroid therapy can safely participate in a dynamic, weight bearing exercise program with positive effects on their physical function, activity and fitness levels, and BMD with no exacerbation of disease activity. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/10914850/A_randomized_controlled_trial_to_evaluate_the_effectiveness_of_an_exercise_program_in_women_with_rheumatoid_arthritis_taking_low_dose_prednisone_ L2 - http://www.diseaseinfosearch.org/result/592 DB - PRIME DP - Unbound Medicine ER -