Tags

Type your tag names separated by a space and hit enter

Effect of low level lead exposure on hyperuricemia and gout among middle aged and elderly men: the normative aging study.
J Rheumatol 2000; 27(7):1708-12JR

Abstract

OBJECTIVE

To determine whether longterm lead accumulation is associated with hyperuricemia and gouty arthritis among middle aged and elderly men.

METHODS

In a retrospective cohort study, 777 male participants were evaluated between August 1991 and October 1996 in the Department of Veterans Affairs Normative Aging Study, a 35 year longitudinal study of aging. We examined the development of gout and an increased uric acid level in relation to lead, adjusting for other known risk factors. Lead levels were measured in blood and by K x-ray fluorescence (K-XRF) technique in tibial (cortical) and patellar (trabecular) bone.

RESULTS

Blood lead levels in this mostly Caucasian (97%) population were low (mean 5.9 microg/dl, SD 3.5). Bone lead levels were comparable to those described in other general populations. In a multivariate analysis adjusting for the risk factors, age, body mass index, diastolic blood pressure, alcohol intake, and serum creatinine level, there was a positive association between patellar bone lead and uric acid levels (p = 0.02). Of 777 participants, 52 (6.7%) had developed gouty arthritis. In logistic regression of similar covariates, body mass index (p < 0.0001) and serum creatinine level (p = 0.005) were the strongest determinants of gout; neither bone nor blood lead levels predicted gout in this cohort.

CONCLUSION

The longterm accumulation of lead is associated with an increased uric acid level in middle aged and elderly men. However, this study shows no association between lead and gouty arthritis at the levels arising from community exposure.

Authors+Show Affiliations

Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10914856

Citation

Shadick, N A., et al. "Effect of Low Level Lead Exposure On Hyperuricemia and Gout Among Middle Aged and Elderly Men: the Normative Aging Study." The Journal of Rheumatology, vol. 27, no. 7, 2000, pp. 1708-12.
Shadick NA, Kim R, Weiss S, et al. Effect of low level lead exposure on hyperuricemia and gout among middle aged and elderly men: the normative aging study. J Rheumatol. 2000;27(7):1708-12.
Shadick, N. A., Kim, R., Weiss, S., Liang, M. H., Sparrow, D., & Hu, H. (2000). Effect of low level lead exposure on hyperuricemia and gout among middle aged and elderly men: the normative aging study. The Journal of Rheumatology, 27(7), pp. 1708-12.
Shadick NA, et al. Effect of Low Level Lead Exposure On Hyperuricemia and Gout Among Middle Aged and Elderly Men: the Normative Aging Study. J Rheumatol. 2000;27(7):1708-12. PubMed PMID: 10914856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of low level lead exposure on hyperuricemia and gout among middle aged and elderly men: the normative aging study. AU - Shadick,N A, AU - Kim,R, AU - Weiss,S, AU - Liang,M H, AU - Sparrow,D, AU - Hu,H, PY - 2000/7/29/pubmed PY - 2001/2/28/medline PY - 2000/7/29/entrez SP - 1708 EP - 12 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 27 IS - 7 N2 - OBJECTIVE: To determine whether longterm lead accumulation is associated with hyperuricemia and gouty arthritis among middle aged and elderly men. METHODS: In a retrospective cohort study, 777 male participants were evaluated between August 1991 and October 1996 in the Department of Veterans Affairs Normative Aging Study, a 35 year longitudinal study of aging. We examined the development of gout and an increased uric acid level in relation to lead, adjusting for other known risk factors. Lead levels were measured in blood and by K x-ray fluorescence (K-XRF) technique in tibial (cortical) and patellar (trabecular) bone. RESULTS: Blood lead levels in this mostly Caucasian (97%) population were low (mean 5.9 microg/dl, SD 3.5). Bone lead levels were comparable to those described in other general populations. In a multivariate analysis adjusting for the risk factors, age, body mass index, diastolic blood pressure, alcohol intake, and serum creatinine level, there was a positive association between patellar bone lead and uric acid levels (p = 0.02). Of 777 participants, 52 (6.7%) had developed gouty arthritis. In logistic regression of similar covariates, body mass index (p < 0.0001) and serum creatinine level (p = 0.005) were the strongest determinants of gout; neither bone nor blood lead levels predicted gout in this cohort. CONCLUSION: The longterm accumulation of lead is associated with an increased uric acid level in middle aged and elderly men. However, this study shows no association between lead and gouty arthritis at the levels arising from community exposure. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/10914856/Effect_of_low_level_lead_exposure_on_hyperuricemia_and_gout_among_middle_aged_and_elderly_men:_the_normative_aging_study_ L2 - https://medlineplus.gov/gout.html DB - PRIME DP - Unbound Medicine ER -