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Erythropoietic activity and soluble transferrin receptor level in neonates and maternal blood.
Acta Paediatr. 2000 Jun; 89(6):675-9.AP

Abstract

Serum transferrin receptor (sTfR) concentration reflects functional iron status and erythropoietic activity. The aims of this study were to examine gender differences of erythropoiesis in newborns and to evaluate the influences of maternal anaemia or iron deficiency on foetal cord blood parameters for iron status and sTfR. In total, 527 newborns and their mothers were examined. Reticulocytes were analysed by flow cytometry and sTfR was measured by an immunoenzymometric method. There were no sex differences in haematological or iron parameters. However, the reticulocyte maturity index (RMI) of male neonates was 37.45%, significantly higher than the 26.81% in female neonates (p <0.01). The high fluorescence reticulocytes (HFR) and middle fluorescence reticulocytes (MFR) of male neonates were 4.91% and 22.36%, respectively, while those of female neonates were 3.31% and 17.83%, respectively (p < 0.01 for each gender). The sTfR concentrations of male and female neonates were 6.27 mg/l and 5.09 mg/l, respectively (p < 0.01). Values for serum iron, ferritin and reticulocyte subpopulations were significantly lower in the newborns of anaemic mothers. However, newborns of iron-deficient mothers showed no differences in iron parameters from those of non-iron-deficient mothers.

CONCLUSIONS

The higher values of RMI and sTfR observed in male neonates indicate that erythropoietic activity is higher in this group. Iron transport to the foetus appears to be independent of maternal iron deficiency. However, iron transport and erythropoiesis in newborns seems to decline from the time that the mothers acquire frank iron deficiency anaemia.

Authors+Show Affiliations

Department of Clinical Pathology, College of Medicine, Inha University, Jung-gu, Inchon, Korea. jwchoi@inha.ac.krNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10914961

Citation

Choi, J W., et al. "Erythropoietic Activity and Soluble Transferrin Receptor Level in Neonates and Maternal Blood." Acta Paediatrica (Oslo, Norway : 1992), vol. 89, no. 6, 2000, pp. 675-9.
Choi JW, Kim CS, Pai SH. Erythropoietic activity and soluble transferrin receptor level in neonates and maternal blood. Acta Paediatr. 2000;89(6):675-9.
Choi, J. W., Kim, C. S., & Pai, S. H. (2000). Erythropoietic activity and soluble transferrin receptor level in neonates and maternal blood. Acta Paediatrica (Oslo, Norway : 1992), 89(6), 675-9.
Choi JW, Kim CS, Pai SH. Erythropoietic Activity and Soluble Transferrin Receptor Level in Neonates and Maternal Blood. Acta Paediatr. 2000;89(6):675-9. PubMed PMID: 10914961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erythropoietic activity and soluble transferrin receptor level in neonates and maternal blood. AU - Choi,J W, AU - Kim,C S, AU - Pai,S H, PY - 2000/7/29/pubmed PY - 2001/2/28/medline PY - 2000/7/29/entrez SP - 675 EP - 9 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr VL - 89 IS - 6 N2 - UNLABELLED: Serum transferrin receptor (sTfR) concentration reflects functional iron status and erythropoietic activity. The aims of this study were to examine gender differences of erythropoiesis in newborns and to evaluate the influences of maternal anaemia or iron deficiency on foetal cord blood parameters for iron status and sTfR. In total, 527 newborns and their mothers were examined. Reticulocytes were analysed by flow cytometry and sTfR was measured by an immunoenzymometric method. There were no sex differences in haematological or iron parameters. However, the reticulocyte maturity index (RMI) of male neonates was 37.45%, significantly higher than the 26.81% in female neonates (p <0.01). The high fluorescence reticulocytes (HFR) and middle fluorescence reticulocytes (MFR) of male neonates were 4.91% and 22.36%, respectively, while those of female neonates were 3.31% and 17.83%, respectively (p < 0.01 for each gender). The sTfR concentrations of male and female neonates were 6.27 mg/l and 5.09 mg/l, respectively (p < 0.01). Values for serum iron, ferritin and reticulocyte subpopulations were significantly lower in the newborns of anaemic mothers. However, newborns of iron-deficient mothers showed no differences in iron parameters from those of non-iron-deficient mothers. CONCLUSIONS: The higher values of RMI and sTfR observed in male neonates indicate that erythropoietic activity is higher in this group. Iron transport to the foetus appears to be independent of maternal iron deficiency. However, iron transport and erythropoiesis in newborns seems to decline from the time that the mothers acquire frank iron deficiency anaemia. SN - 0803-5253 UR - https://www.unboundmedicine.com/medline/citation/10914961/Erythropoietic_activity_and_soluble_transferrin_receptor_level_in_neonates_and_maternal_blood_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0803-5253&amp;date=2000&amp;volume=89&amp;issue=6&amp;spage=675 DB - PRIME DP - Unbound Medicine ER -