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Thymus dependence of the IgA response to sheep erythrocytes.
Immunology. 1975 Feb; 28(2):287-91.I

Abstract

The thumus dependence of the IgA response to sheep red blooc cells (SRBC) was studied by means of cell transfer experiments in mice. Only low numbers of IgM-, IgG- and IgA-plaque-forming cells (PFC) were observed in those recipients which received only spleen cells from adult thymectomized, irradiated and bone marrow-reconstituted mice (B cells). High numbers of IgM-, IgG- and IgA-PFC were observed when B cells and educated T cells were transferred to the recipients. Evidence is provided that B cells committed to IgA synthesis require the same degree of interaction with T cells as B cells committed to IgM synthesis, but a lower degree of interaction with T cells than B cells committed to IgG synthesis.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1091544

Citation

van Muiswinkel, W B., and P L. van Soest. "Thymus Dependence of the IgA Response to Sheep Erythrocytes." Immunology, vol. 28, no. 2, 1975, pp. 287-91.
van Muiswinkel WB, van Soest PL. Thymus dependence of the IgA response to sheep erythrocytes. Immunology. 1975;28(2):287-91.
van Muiswinkel, W. B., & van Soest, P. L. (1975). Thymus dependence of the IgA response to sheep erythrocytes. Immunology, 28(2), 287-91.
van Muiswinkel WB, van Soest PL. Thymus Dependence of the IgA Response to Sheep Erythrocytes. Immunology. 1975;28(2):287-91. PubMed PMID: 1091544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thymus dependence of the IgA response to sheep erythrocytes. AU - van Muiswinkel,W B, AU - van Soest,P L, PY - 1975/2/1/pubmed PY - 1975/2/1/medline PY - 1975/2/1/entrez SP - 287 EP - 91 JF - Immunology JO - Immunology VL - 28 IS - 2 N2 - The thumus dependence of the IgA response to sheep red blooc cells (SRBC) was studied by means of cell transfer experiments in mice. Only low numbers of IgM-, IgG- and IgA-plaque-forming cells (PFC) were observed in those recipients which received only spleen cells from adult thymectomized, irradiated and bone marrow-reconstituted mice (B cells). High numbers of IgM-, IgG- and IgA-PFC were observed when B cells and educated T cells were transferred to the recipients. Evidence is provided that B cells committed to IgA synthesis require the same degree of interaction with T cells as B cells committed to IgM synthesis, but a lower degree of interaction with T cells than B cells committed to IgG synthesis. SN - 0019-2805 UR - https://www.unboundmedicine.com/medline/citation/1091544/Thymus_dependence_of_the_IgA_response_to_sheep_erythrocytes_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1091544/ DB - PRIME DP - Unbound Medicine ER -