Tags

Type your tag names separated by a space and hit enter

Increased partitioning of pilocarpine to the oily phase of submicron emulsion does not result in improved ocular bioavailability.
Int J Pharm. 2000 Jul 20; 202(1-2):161-4.IJ

Abstract

Submicron emulsions containing pilocarpine as ion-pair with mono-dodecylphosphoric acid were prepared. Physical stability of these preparations was confirmed during 4 months of storage at 4 degrees C. Approximately 50% of the drug was found in the aqueous phase of emulsion separated using an ultrafiltration technique, while the rest was present in the oily phase and interphase. The miotic effect observed in rabbits after application of the ion-pair in aqueous solution or in submicron emulsion was the same; indicating that the drug distribution into the oily phase of the colloidal vehicle does not improve ocular bioavailability.

Authors+Show Affiliations

Department of Pharmaceutical Technology, Medical University of Gdansk, ul. Hallera 107, 80-416, Gdansk, Poland. msznito@farmacja.amg.gda.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10915939

Citation

Sznitowska, M, et al. "Increased Partitioning of Pilocarpine to the Oily Phase of Submicron Emulsion Does Not Result in Improved Ocular Bioavailability." International Journal of Pharmaceutics, vol. 202, no. 1-2, 2000, pp. 161-4.
Sznitowska M, Zurowska-Pryczkowska K, Dabrowska E, et al. Increased partitioning of pilocarpine to the oily phase of submicron emulsion does not result in improved ocular bioavailability. Int J Pharm. 2000;202(1-2):161-4.
Sznitowska, M., Zurowska-Pryczkowska, K., Dabrowska, E., & Janicki, S. (2000). Increased partitioning of pilocarpine to the oily phase of submicron emulsion does not result in improved ocular bioavailability. International Journal of Pharmaceutics, 202(1-2), 161-4.
Sznitowska M, et al. Increased Partitioning of Pilocarpine to the Oily Phase of Submicron Emulsion Does Not Result in Improved Ocular Bioavailability. Int J Pharm. 2000 Jul 20;202(1-2):161-4. PubMed PMID: 10915939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased partitioning of pilocarpine to the oily phase of submicron emulsion does not result in improved ocular bioavailability. AU - Sznitowska,M, AU - Zurowska-Pryczkowska,K, AU - Dabrowska,E, AU - Janicki,S, PY - 2000/8/1/pubmed PY - 2000/9/9/medline PY - 2000/8/1/entrez SP - 161 EP - 4 JF - International journal of pharmaceutics JO - Int J Pharm VL - 202 IS - 1-2 N2 - Submicron emulsions containing pilocarpine as ion-pair with mono-dodecylphosphoric acid were prepared. Physical stability of these preparations was confirmed during 4 months of storage at 4 degrees C. Approximately 50% of the drug was found in the aqueous phase of emulsion separated using an ultrafiltration technique, while the rest was present in the oily phase and interphase. The miotic effect observed in rabbits after application of the ion-pair in aqueous solution or in submicron emulsion was the same; indicating that the drug distribution into the oily phase of the colloidal vehicle does not improve ocular bioavailability. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/10915939/Increased_partitioning_of_pilocarpine_to_the_oily_phase_of_submicron_emulsion_does_not_result_in_improved_ocular_bioavailability_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378517300004439 DB - PRIME DP - Unbound Medicine ER -