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Autonomic nervous function in de novo parkinsonian patients in basal condition and after acute levodopa administration.
Funct Neurol. 2000 Apr-Jun; 15(2):81-6.FN

Abstract

The aims of this study were to assess autonomic nervous function in subjects with recently diagnosed Parkinson's disease (de novo patients) and to evaluate its changes following acute levodopa administration. In 13 patients (8 males, 5 females) and 13 age-matched control subjects, three cardiovascular autonomic function tests (Deep Breathing, Valsalva, Lying to Standing) were performed, the QT interval was calculated on a 12-lead electrocardiogram, and the response of plasma norepinephrine to standing was assessed in basal conditions. The cardiovascular tests and the measurement of the QT interval were repeated in de novo Parkinsonian patients 90 minutes after the administration of levodopa 200 mg per os. The results of the Deep Breathing and Valsalva tests were worse and the QT interval longer in patients than in control subjects (although the differences were not statistically significant). The heart rate increase at 30 seconds after standing up was significantly higher in Parkinsonian patients than in the control group. The response of plasma norepinephrine to standing was similar in both groups. Levodopa administration produced a slight improvement in the Deep Breathing test, a shortening of the QT interval and increased tachycardia on standing. Our data suggest that a mild subclinical impairment of parasympathetic function can be a feature of de novo Parkinsonian patients and that levodopa therapy could have a beneficial effect on this autonomic dysfunction.

Authors+Show Affiliations

Department of Medicine and Experimental Oncology, San Vito Hospital, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10916719

Citation

Quadri, R, et al. "Autonomic Nervous Function in De Novo Parkinsonian Patients in Basal Condition and After Acute Levodopa Administration." Functional Neurology, vol. 15, no. 2, 2000, pp. 81-6.
Quadri R, Comino I, Scarzella L, et al. Autonomic nervous function in de novo parkinsonian patients in basal condition and after acute levodopa administration. Funct Neurol. 2000;15(2):81-6.
Quadri, R., Comino, I., Scarzella, L., Cacioli, P., Zanone, M. M., Pipieri, A., Bergamasco, B., & Chiandussi, L. (2000). Autonomic nervous function in de novo parkinsonian patients in basal condition and after acute levodopa administration. Functional Neurology, 15(2), 81-6.
Quadri R, et al. Autonomic Nervous Function in De Novo Parkinsonian Patients in Basal Condition and After Acute Levodopa Administration. Funct Neurol. 2000 Apr-Jun;15(2):81-6. PubMed PMID: 10916719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic nervous function in de novo parkinsonian patients in basal condition and after acute levodopa administration. AU - Quadri,R, AU - Comino,I, AU - Scarzella,L, AU - Cacioli,P, AU - Zanone,M M, AU - Pipieri,A, AU - Bergamasco,B, AU - Chiandussi,L, PY - 2000/8/5/pubmed PY - 2001/2/28/medline PY - 2000/8/5/entrez SP - 81 EP - 6 JF - Functional neurology JO - Funct Neurol VL - 15 IS - 2 N2 - The aims of this study were to assess autonomic nervous function in subjects with recently diagnosed Parkinson's disease (de novo patients) and to evaluate its changes following acute levodopa administration. In 13 patients (8 males, 5 females) and 13 age-matched control subjects, three cardiovascular autonomic function tests (Deep Breathing, Valsalva, Lying to Standing) were performed, the QT interval was calculated on a 12-lead electrocardiogram, and the response of plasma norepinephrine to standing was assessed in basal conditions. The cardiovascular tests and the measurement of the QT interval were repeated in de novo Parkinsonian patients 90 minutes after the administration of levodopa 200 mg per os. The results of the Deep Breathing and Valsalva tests were worse and the QT interval longer in patients than in control subjects (although the differences were not statistically significant). The heart rate increase at 30 seconds after standing up was significantly higher in Parkinsonian patients than in the control group. The response of plasma norepinephrine to standing was similar in both groups. Levodopa administration produced a slight improvement in the Deep Breathing test, a shortening of the QT interval and increased tachycardia on standing. Our data suggest that a mild subclinical impairment of parasympathetic function can be a feature of de novo Parkinsonian patients and that levodopa therapy could have a beneficial effect on this autonomic dysfunction. SN - 0393-5264 UR - https://www.unboundmedicine.com/medline/citation/10916719/Autonomic_nervous_function_in_de_novo_parkinsonian_patients_in_basal_condition_and_after_acute_levodopa_administration_ L2 - https://medlineplus.gov/highbloodpressure.html DB - PRIME DP - Unbound Medicine ER -