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Leukocytosis in children with Escherichia coli O157:H7 enteritis developing the hemolytic-uremic syndrome.
Pediatr Infect Dis J. 2000 Jul; 19(7):642-7.PI

Abstract

BACKGROUND

Fewer than 10% of children with Escherichia coli O157:H7 enteritis develop hemolytic-uremic syndrome (HUS).

OBJECTIVE

To determine whether circulating leukocytes are independent risk markers of developing HUS during E. coli O157:H7 enteritis.

METHODS

We reviewed the charts of all children with culture-proved E. coli O157:H7 infections seen at Sainte-Justine Hospital between 1987 and 1997. Epidemiologic data, laboratory indices and circulating leukocytes counts were noted. HUS diagnosis was validated with independent HUS patient lists from the pediatric nephrology services of tertiary care hospitals in the Montreal metropolitan area. The date of onset of enteritis was determined by two independent observers. Leukocyte counts were compared among the following independent groups: (1) uncomplicated O157:H7 enteritis (Group 1); (2) O157:H7 enteritis with the subsequent development of HUS (Group 2); (3) HUS already present at the time of medical consultation (Group 3).

RESULTS

There were 369 children with E. coli O157:H7 infection. A complete blood count was not performed in 114 (31%) patients. Observers disagreed on the date of onset of gastroenteritis in 34 (9%) children only (kappa 0.92). The study population thus included 221 patients: Group 1, n = 161; Group 2, n = 27; and Group 3, n = 33. Patients developing HUS (Group 2) presented greater total leukocyte (P < 0.008), polymorphonuclear (P < 0.008) and monocyte (P < 0.07) counts than those with an uncomplicated course (Group 1). Logistic regression analysis showed that young age [odds ratio (OR), 0.98; 95% confidence interval (CI), 0.96 to 0.99], duration of enteric prodrome < or =3 days (OR 4.8, 95% CI 1.13 to 20.7) and initial leukocytosis (OR 1.22, 95% CI, 1.11 to 1.35) were independent predictors of HUS.

CONCLUSIONS

Based on the variables identified above, further studies are needed to determine whether the inflammatory response of the host represents only a marker of the severity of gastrointestinal infection or whether, alternatively, it is a pathophysiologic factor that leads to HUS.

Authors+Show Affiliations

Department of Pediatrics, Sainte-Justine Hospital, University of Montreal, Quebec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10917223

Citation

Buteau, C, et al. "Leukocytosis in Children With Escherichia Coli O157:H7 Enteritis Developing the Hemolytic-uremic Syndrome." The Pediatric Infectious Disease Journal, vol. 19, no. 7, 2000, pp. 642-7.
Buteau C, Proulx F, Chaibou M, et al. Leukocytosis in children with Escherichia coli O157:H7 enteritis developing the hemolytic-uremic syndrome. Pediatr Infect Dis J. 2000;19(7):642-7.
Buteau, C., Proulx, F., Chaibou, M., Raymond, D., Clermont, M. J., Mariscalco, M. M., Lebel, M. H., & Seidman, E. (2000). Leukocytosis in children with Escherichia coli O157:H7 enteritis developing the hemolytic-uremic syndrome. The Pediatric Infectious Disease Journal, 19(7), 642-7.
Buteau C, et al. Leukocytosis in Children With Escherichia Coli O157:H7 Enteritis Developing the Hemolytic-uremic Syndrome. Pediatr Infect Dis J. 2000;19(7):642-7. PubMed PMID: 10917223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leukocytosis in children with Escherichia coli O157:H7 enteritis developing the hemolytic-uremic syndrome. AU - Buteau,C, AU - Proulx,F, AU - Chaibou,M, AU - Raymond,D, AU - Clermont,M J, AU - Mariscalco,M M, AU - Lebel,M H, AU - Seidman,E, PY - 2000/8/5/pubmed PY - 2001/2/28/medline PY - 2000/8/5/entrez SP - 642 EP - 7 JF - The Pediatric infectious disease journal JO - Pediatr. Infect. Dis. J. VL - 19 IS - 7 N2 - BACKGROUND: Fewer than 10% of children with Escherichia coli O157:H7 enteritis develop hemolytic-uremic syndrome (HUS). OBJECTIVE: To determine whether circulating leukocytes are independent risk markers of developing HUS during E. coli O157:H7 enteritis. METHODS: We reviewed the charts of all children with culture-proved E. coli O157:H7 infections seen at Sainte-Justine Hospital between 1987 and 1997. Epidemiologic data, laboratory indices and circulating leukocytes counts were noted. HUS diagnosis was validated with independent HUS patient lists from the pediatric nephrology services of tertiary care hospitals in the Montreal metropolitan area. The date of onset of enteritis was determined by two independent observers. Leukocyte counts were compared among the following independent groups: (1) uncomplicated O157:H7 enteritis (Group 1); (2) O157:H7 enteritis with the subsequent development of HUS (Group 2); (3) HUS already present at the time of medical consultation (Group 3). RESULTS: There were 369 children with E. coli O157:H7 infection. A complete blood count was not performed in 114 (31%) patients. Observers disagreed on the date of onset of gastroenteritis in 34 (9%) children only (kappa 0.92). The study population thus included 221 patients: Group 1, n = 161; Group 2, n = 27; and Group 3, n = 33. Patients developing HUS (Group 2) presented greater total leukocyte (P < 0.008), polymorphonuclear (P < 0.008) and monocyte (P < 0.07) counts than those with an uncomplicated course (Group 1). Logistic regression analysis showed that young age [odds ratio (OR), 0.98; 95% confidence interval (CI), 0.96 to 0.99], duration of enteric prodrome < or =3 days (OR 4.8, 95% CI 1.13 to 20.7) and initial leukocytosis (OR 1.22, 95% CI, 1.11 to 1.35) were independent predictors of HUS. CONCLUSIONS: Based on the variables identified above, further studies are needed to determine whether the inflammatory response of the host represents only a marker of the severity of gastrointestinal infection or whether, alternatively, it is a pathophysiologic factor that leads to HUS. SN - 0891-3668 UR - https://www.unboundmedicine.com/medline/citation/10917223/Leukocytosis_in_children_with_Escherichia_coli_O157:H7_enteritis_developing_the_hemolytic_uremic_syndrome_ L2 - http://dx.doi.org/10.1097/00006454-200007000-00012 DB - PRIME DP - Unbound Medicine ER -