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Genetic influences on premature parturition in an Australian twin sample.
Twin Res 2000; 3(2):80-2TR

Abstract

We investigated possible genetic influences on women's liability to preterm birth, using data from a large sample of Australian female twin pairs. In a 1988-90 questionnaire survey, both members of 905 parous twin pairs (579 monozygotic and 326 dizygotic) reported on whether deliveries had been more than two weeks preterm. Tetrachoric twin pair correlations for first birth were rMZ = 0.20+/-0.11 and rDZ = -0.03+/-0.14, and for any birth were rMZ = 0.30+/-0.08 and rDZ = 0.03+/-0.11. Best-fitting models to data contained only additive genetic influences and individual environmental effects. Heritability was 17% for preterm delivery in first pregnancy, and 27% for preterm delivery in any pregnancy. In the former case, however, we could not reject a model without genetic influences. Although our data did not allow for differentiation of the varying aetiologies of premature parturition, results from this exploratory analysis suggest that further investigation of genetic influences on specific reasons for preterm birth is warranted.

Authors+Show Affiliations

Queensland Institute of Medical Research and Joint Genetics Program, The University of Queensland, Brisbane, Australia. sueT@qimr.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

10918619

Citation

Treloar, S A., et al. "Genetic Influences On Premature Parturition in an Australian Twin Sample." Twin Research : the Official Journal of the International Society for Twin Studies, vol. 3, no. 2, 2000, pp. 80-2.
Treloar SA, Macones GA, Mitchell LE, et al. Genetic influences on premature parturition in an Australian twin sample. Twin Res. 2000;3(2):80-2.
Treloar, S. A., Macones, G. A., Mitchell, L. E., & Martin, N. G. (2000). Genetic influences on premature parturition in an Australian twin sample. Twin Research : the Official Journal of the International Society for Twin Studies, 3(2), pp. 80-2.
Treloar SA, et al. Genetic Influences On Premature Parturition in an Australian Twin Sample. Twin Res. 2000;3(2):80-2. PubMed PMID: 10918619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic influences on premature parturition in an Australian twin sample. AU - Treloar,S A, AU - Macones,G A, AU - Mitchell,L E, AU - Martin,N G, PY - 2000/8/6/pubmed PY - 2001/2/28/medline PY - 2000/8/6/entrez SP - 80 EP - 2 JF - Twin research : the official journal of the International Society for Twin Studies JO - Twin Res VL - 3 IS - 2 N2 - We investigated possible genetic influences on women's liability to preterm birth, using data from a large sample of Australian female twin pairs. In a 1988-90 questionnaire survey, both members of 905 parous twin pairs (579 monozygotic and 326 dizygotic) reported on whether deliveries had been more than two weeks preterm. Tetrachoric twin pair correlations for first birth were rMZ = 0.20+/-0.11 and rDZ = -0.03+/-0.14, and for any birth were rMZ = 0.30+/-0.08 and rDZ = 0.03+/-0.11. Best-fitting models to data contained only additive genetic influences and individual environmental effects. Heritability was 17% for preterm delivery in first pregnancy, and 27% for preterm delivery in any pregnancy. In the former case, however, we could not reject a model without genetic influences. Although our data did not allow for differentiation of the varying aetiologies of premature parturition, results from this exploratory analysis suggest that further investigation of genetic influences on specific reasons for preterm birth is warranted. SN - 1369-0523 UR - https://www.unboundmedicine.com/medline/citation/10918619/Genetic_influences_on_premature_parturition_in_an_Australian_twin_sample_ L2 - https://ClinicalTrials.gov/search/term=10918619 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -