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Moderate alcohol consumption and risk of coronary heart disease among women with type 2 diabetes mellitus.

Abstract

BACKGROUND

Moderate alcohol consumption is associated with reduced risk for coronary heart disease (CHD) in generally healthy populations. We assessed prospectively the association between moderate alcohol intake and CHD risk in women with type 2 diabetes mellitus, a group at high risk for cardiovascular disease.

METHODS AND RESULTS

We studied women in the Nurses' Health Study who reported a diagnosis of diabetes mellitus at >/=30 years of age. During 39 092 person-years of follow-up from 1980 to 1994, there were 295 CHD events documented among this population, including 194 cases of nonfatal myocardial infarction and 101 cases of fatal CHD. Odds ratios derived from logistic regression were used to estimate relative risks (RRs) for CHD as a function of usual alcohol intake, with adjustment for potential confounders. Compared with diabetic women reporting no alcohol intake, the age-adjusted RR for nonfatal or fatal CHD among diabetic women reporting usual intake of 0.1 to 4.9 g (<0.5 drinks) of alcohol daily was 0.74 (95% CI 0.56 to 0.98), and among those reporting usual intake >/=5 g/d, it was 0.48 (95% CI 0.32 to 0.72) (P for trend <0.0001). Inverse associations between alcohol intake and CHD risk remained significant in multivariate analysis adjusting for several other coronary risk factors (0.1 to 4. 9 g/d: RR 0.72 [95% CI 0.54 to 0.96]; >/=5 g/d: RR 0.45 [0.29 to 0.68]).

CONCLUSIONS

Although potential risks of alcohol consumption must be considered, these data suggest that moderate alcohol consumption is associated with reduced CHD risk in women with diabetes and should not be routinely discouraged.

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  • Authors+Show Affiliations

    ,

    Division of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. cgsolomon@bics.bwh.harvard.edu

    , , , , , ,

    Source

    Circulation 102:5 2000 Aug 01 pg 494-9

    MeSH

    Adult
    Alcohol Drinking
    Body Mass Index
    Cohort Studies
    Coronary Disease
    Diabetes Mellitus, Type 2
    Diabetic Angiopathies
    Female
    Humans
    Hypertension
    Middle Aged
    Multivariate Analysis
    Myocardial Infarction
    Nurses
    Risk
    Risk Factors
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10920059

    Citation

    Solomon, C G., et al. "Moderate Alcohol Consumption and Risk of Coronary Heart Disease Among Women With Type 2 Diabetes Mellitus." Circulation, vol. 102, no. 5, 2000, pp. 494-9.
    Solomon CG, Hu FB, Stampfer MJ, et al. Moderate alcohol consumption and risk of coronary heart disease among women with type 2 diabetes mellitus. Circulation. 2000;102(5):494-9.
    Solomon, C. G., Hu, F. B., Stampfer, M. J., Colditz, G. A., Speizer, F. E., Rimm, E. B., ... Manson, J. E. (2000). Moderate alcohol consumption and risk of coronary heart disease among women with type 2 diabetes mellitus. Circulation, 102(5), pp. 494-9.
    Solomon CG, et al. Moderate Alcohol Consumption and Risk of Coronary Heart Disease Among Women With Type 2 Diabetes Mellitus. Circulation. 2000 Aug 1;102(5):494-9. PubMed PMID: 10920059.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Moderate alcohol consumption and risk of coronary heart disease among women with type 2 diabetes mellitus. AU - Solomon,C G, AU - Hu,F B, AU - Stampfer,M J, AU - Colditz,G A, AU - Speizer,F E, AU - Rimm,E B, AU - Willett,W C, AU - Manson,J E, PY - 2000/8/2/pubmed PY - 2000/8/19/medline PY - 2000/8/2/entrez SP - 494 EP - 9 JF - Circulation JO - Circulation VL - 102 IS - 5 N2 - BACKGROUND: Moderate alcohol consumption is associated with reduced risk for coronary heart disease (CHD) in generally healthy populations. We assessed prospectively the association between moderate alcohol intake and CHD risk in women with type 2 diabetes mellitus, a group at high risk for cardiovascular disease. METHODS AND RESULTS: We studied women in the Nurses' Health Study who reported a diagnosis of diabetes mellitus at >/=30 years of age. During 39 092 person-years of follow-up from 1980 to 1994, there were 295 CHD events documented among this population, including 194 cases of nonfatal myocardial infarction and 101 cases of fatal CHD. Odds ratios derived from logistic regression were used to estimate relative risks (RRs) for CHD as a function of usual alcohol intake, with adjustment for potential confounders. Compared with diabetic women reporting no alcohol intake, the age-adjusted RR for nonfatal or fatal CHD among diabetic women reporting usual intake of 0.1 to 4.9 g (<0.5 drinks) of alcohol daily was 0.74 (95% CI 0.56 to 0.98), and among those reporting usual intake >/=5 g/d, it was 0.48 (95% CI 0.32 to 0.72) (P for trend <0.0001). Inverse associations between alcohol intake and CHD risk remained significant in multivariate analysis adjusting for several other coronary risk factors (0.1 to 4. 9 g/d: RR 0.72 [95% CI 0.54 to 0.96]; >/=5 g/d: RR 0.45 [0.29 to 0.68]). CONCLUSIONS: Although potential risks of alcohol consumption must be considered, these data suggest that moderate alcohol consumption is associated with reduced CHD risk in women with diabetes and should not be routinely discouraged. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/10920059/Moderate_alcohol_consumption_and_risk_of_coronary_heart_disease_among_women_with_type_2_diabetes_mellitus_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=10920059.ui DB - PRIME DP - Unbound Medicine ER -