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Differential effects of beta-blockers in patients with heart failure: A prospective, randomized, double-blind comparison of the long-term effects of metoprolol versus carvedilol.
Circulation. 2000 Aug 01; 102(5):546-51.Circ

Abstract

BACKGROUND

Both metoprolol and carvedilol produce hemodynamic and clinical benefits in patients with chronic heart failure; carvedilol exerts greater antiadrenergic effects than metoprolol, but it is unknown whether this pharmacological difference results in hemodynamic and clinical differences between the 2 drugs.

METHODS AND RESULTS

We randomized 150 patients with heart failure (left ventricular ejection fraction </=0.35) to double-blind treatment with either metoprolol or carvedilol. When compared with metoprolol (124+/-55 mg/d), patients treated with carvedilol (49+/-18 mg/d) showed larger increases in left ventricular ejection fraction at rest (+10.9+/-11.0 versus +7.2+/-7.7 U, P=0.038) and in left ventricular stroke volume and stroke work during exercise (both P<0. 05) after 13 to 15 months of treatment. In addition, carvedilol produced greater decreases in mean pulmonary artery pressure and pulmonary wedge pressure, both at rest and during exercise, than metoprolol (all P<0.05). In contrast, the metoprolol group showed greater increases in maximal exercise capacity than the carvedilol group (P=0.035), but the 2 drugs improved symptoms, submaximal exercise tolerance, and quality of life to a similar degree. After a mean of 23+/-11 months of follow-up, 21 patients in the metoprolol group and 17 patients in the carvedilol group died or underwent urgent transplantation.

CONCLUSIONS

The present study demonstrates that during long-term therapy, carvedilol improves cardiac performance to a greater extent than metoprolol when administered to patients with heart failure in the doses shown to be effective in clinical trials. These differences were likely related to a greater antiadrenergic activity of carvedilol.

Authors+Show Affiliations

Cattedra di Cardiologia, Università di Brescia, Italy. metramarco@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10920067

Citation

Metra, M, et al. "Differential Effects of Beta-blockers in Patients With Heart Failure: a Prospective, Randomized, Double-blind Comparison of the Long-term Effects of Metoprolol Versus Carvedilol." Circulation, vol. 102, no. 5, 2000, pp. 546-51.
Metra M, Giubbini R, Nodari S, et al. Differential effects of beta-blockers in patients with heart failure: A prospective, randomized, double-blind comparison of the long-term effects of metoprolol versus carvedilol. Circulation. 2000;102(5):546-51.
Metra, M., Giubbini, R., Nodari, S., Boldi, E., Modena, M. G., & Dei Cas, L. (2000). Differential effects of beta-blockers in patients with heart failure: A prospective, randomized, double-blind comparison of the long-term effects of metoprolol versus carvedilol. Circulation, 102(5), 546-51.
Metra M, et al. Differential Effects of Beta-blockers in Patients With Heart Failure: a Prospective, Randomized, Double-blind Comparison of the Long-term Effects of Metoprolol Versus Carvedilol. Circulation. 2000 Aug 1;102(5):546-51. PubMed PMID: 10920067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential effects of beta-blockers in patients with heart failure: A prospective, randomized, double-blind comparison of the long-term effects of metoprolol versus carvedilol. AU - Metra,M, AU - Giubbini,R, AU - Nodari,S, AU - Boldi,E, AU - Modena,M G, AU - Dei Cas,L, PY - 2000/8/2/pubmed PY - 2000/8/19/medline PY - 2000/8/2/entrez SP - 546 EP - 51 JF - Circulation JO - Circulation VL - 102 IS - 5 N2 - BACKGROUND: Both metoprolol and carvedilol produce hemodynamic and clinical benefits in patients with chronic heart failure; carvedilol exerts greater antiadrenergic effects than metoprolol, but it is unknown whether this pharmacological difference results in hemodynamic and clinical differences between the 2 drugs. METHODS AND RESULTS: We randomized 150 patients with heart failure (left ventricular ejection fraction </=0.35) to double-blind treatment with either metoprolol or carvedilol. When compared with metoprolol (124+/-55 mg/d), patients treated with carvedilol (49+/-18 mg/d) showed larger increases in left ventricular ejection fraction at rest (+10.9+/-11.0 versus +7.2+/-7.7 U, P=0.038) and in left ventricular stroke volume and stroke work during exercise (both P<0. 05) after 13 to 15 months of treatment. In addition, carvedilol produced greater decreases in mean pulmonary artery pressure and pulmonary wedge pressure, both at rest and during exercise, than metoprolol (all P<0.05). In contrast, the metoprolol group showed greater increases in maximal exercise capacity than the carvedilol group (P=0.035), but the 2 drugs improved symptoms, submaximal exercise tolerance, and quality of life to a similar degree. After a mean of 23+/-11 months of follow-up, 21 patients in the metoprolol group and 17 patients in the carvedilol group died or underwent urgent transplantation. CONCLUSIONS: The present study demonstrates that during long-term therapy, carvedilol improves cardiac performance to a greater extent than metoprolol when administered to patients with heart failure in the doses shown to be effective in clinical trials. These differences were likely related to a greater antiadrenergic activity of carvedilol. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/10920067/Differential_effects_of_beta_blockers_in_patients_with_heart_failure:_A_prospective_randomized_double_blind_comparison_of_the_long_term_effects_of_metoprolol_versus_carvedilol_ L2 - https://www.ahajournals.org/doi/10.1161/01.cir.102.5.546?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -