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Aging affects the retrobulbar circulation differently in women and men.
Arch Ophthalmol. 2000 Aug; 118(8):1076-80.AO

Abstract

BACKGROUND

While aging clearly has protean biological effects on every organ system, the differential effects of aging in women and men in the retrobulbar vasculature, to our knowledge, have never been investigated. Because glaucoma and age-related macular degeneration are closely linked to advanced age, we performed a cross-sectional study using color Doppler imaging of 4 retrobulbar vessels in both healthy women and men.

OBJECTIVE

To define the influence of aging per se on ocular hemodynamics.

METHODS

Women (n = 73) and men (n = 55), aged from 20 to 90 years, free of ocular and systemic disease, and with normal intraocular pressure, were recruited for this study. Postmenopausal women who were not receiving estrogen replacement therapy were also recruited. Studies involved color Doppler imaging analysis of the ophthalmic, central retinal, and nasal and temporal posterior ciliary arteries. Ophthalmic arterial peak systolic and end-diastolic velocities and a Pourcelot resistance index were determined for each vessel.

RESULTS

In both sexes, ophthalmic arterial end-diastolic velocity decreased and the Pourcelot resistance index rose with advancing age (each P<. 001); peak systolic velocity in the ophthalmic vessel was age-independent. In contrast, central retinal arterial flow velocities were unaffected by age in both sexes. In the posterior ciliary arteries, in men, flow velocities and the Pourcelot resistance index were independent of age. However, in women, end-diastolic velocity decreased with age in both the nasal and temporal posterior ciliary vessel (each P<.05); peak systolic velocity was constant; the Pourcelot resistance index in each ciliary artery rose with advancing age (each P<.05).

CONCLUSION

In healthy women and men, aging-induced changes in retrobulbar hemodynamics are comparable to alterations seen in patients with glaucoma or age-related macular degeneration, suggesting that vascular changes with senescence may contribute to increased risk for these diseases in older age. Arch Ophthalmol. 2000;118:1076-1080

Authors+Show Affiliations

Department of Ophthalmology, Indiana University, School of Medicine, Indianapolis, IN 46202 USA. alharris@indiana.edu.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10922201

Citation

Harris, A, et al. "Aging Affects the Retrobulbar Circulation Differently in Women and Men." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 118, no. 8, 2000, pp. 1076-80.
Harris A, Harris M, Biller J, et al. Aging affects the retrobulbar circulation differently in women and men. Arch Ophthalmol. 2000;118(8):1076-80.
Harris, A., Harris, M., Biller, J., Garzozi, H., Zarfty, D., Ciulla, T. A., & Martin, B. (2000). Aging affects the retrobulbar circulation differently in women and men. Archives of Ophthalmology (Chicago, Ill. : 1960), 118(8), 1076-80.
Harris A, et al. Aging Affects the Retrobulbar Circulation Differently in Women and Men. Arch Ophthalmol. 2000;118(8):1076-80. PubMed PMID: 10922201.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aging affects the retrobulbar circulation differently in women and men. AU - Harris,A, AU - Harris,M, AU - Biller,J, AU - Garzozi,H, AU - Zarfty,D, AU - Ciulla,T A, AU - Martin,B, PY - 2000/8/2/pubmed PY - 2000/8/19/medline PY - 2000/8/2/entrez SP - 1076 EP - 80 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch Ophthalmol VL - 118 IS - 8 N2 - BACKGROUND: While aging clearly has protean biological effects on every organ system, the differential effects of aging in women and men in the retrobulbar vasculature, to our knowledge, have never been investigated. Because glaucoma and age-related macular degeneration are closely linked to advanced age, we performed a cross-sectional study using color Doppler imaging of 4 retrobulbar vessels in both healthy women and men. OBJECTIVE: To define the influence of aging per se on ocular hemodynamics. METHODS: Women (n = 73) and men (n = 55), aged from 20 to 90 years, free of ocular and systemic disease, and with normal intraocular pressure, were recruited for this study. Postmenopausal women who were not receiving estrogen replacement therapy were also recruited. Studies involved color Doppler imaging analysis of the ophthalmic, central retinal, and nasal and temporal posterior ciliary arteries. Ophthalmic arterial peak systolic and end-diastolic velocities and a Pourcelot resistance index were determined for each vessel. RESULTS: In both sexes, ophthalmic arterial end-diastolic velocity decreased and the Pourcelot resistance index rose with advancing age (each P<. 001); peak systolic velocity in the ophthalmic vessel was age-independent. In contrast, central retinal arterial flow velocities were unaffected by age in both sexes. In the posterior ciliary arteries, in men, flow velocities and the Pourcelot resistance index were independent of age. However, in women, end-diastolic velocity decreased with age in both the nasal and temporal posterior ciliary vessel (each P<.05); peak systolic velocity was constant; the Pourcelot resistance index in each ciliary artery rose with advancing age (each P<.05). CONCLUSION: In healthy women and men, aging-induced changes in retrobulbar hemodynamics are comparable to alterations seen in patients with glaucoma or age-related macular degeneration, suggesting that vascular changes with senescence may contribute to increased risk for these diseases in older age. Arch Ophthalmol. 2000;118:1076-1080 SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/10922201/Aging_affects_the_retrobulbar_circulation_differently_in_women_and_men_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/vol/118/pg/1076 DB - PRIME DP - Unbound Medicine ER -