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Increasing maternal weight: a risk factor for preeclampsia/eclampsia but apparently not for HELLP syndrome.
South Med J. 2000 Jul; 93(7):686-91.SM

Abstract

BACKGROUND

Maternal obesity is a risk factor for severe preeclampsia. We sought to ascertain whether a similar relationship exists between maternal weight and HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) as an atypical form of severe preeclampsia.

METHODS

In this retrospective investigation, 434 patients with HELLP syndrome were assigned to one of four study groups according to maternal weight and were analyzed in relation to selected maternal and perinatal data reflective of disease severity.

RESULTS

We found no significant associations between maternal weight and parameters of HELLP syndrome severity, race, delivery mode, gestational age, or perinatal outcome. Significantly associated with increasing maternal weight were maternal age, parity, admission mean arterial pressure, peak peripartum systolic blood pressures, concurrent essential hypertension, and the interval between admission and delivery. Inversely associated were eclampsia and the interval between delivery and discharge.

CONCLUSIONS

Severity and complications attendant with HELLP syndrome appear unrelated to maternal weight. Paradoxically, eclampsia occurs most commonly in the lighter gravida with HELLP syndrome.

Authors+Show Affiliations

Department of Obstetrics and Gynecology and Preventive Medicine, University of Mississippi Medical Center, Jackson 39216-4505, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10923957

Citation

Martin, J N., et al. "Increasing Maternal Weight: a Risk Factor for Preeclampsia/eclampsia but Apparently Not for HELLP Syndrome." Southern Medical Journal, vol. 93, no. 7, 2000, pp. 686-91.
Martin JN, May WL, Rinehart BK, et al. Increasing maternal weight: a risk factor for preeclampsia/eclampsia but apparently not for HELLP syndrome. South Med J. 2000;93(7):686-91.
Martin, J. N., May, W. L., Rinehart, B. K., Martin, R. W., & Magann, E. F. (2000). Increasing maternal weight: a risk factor for preeclampsia/eclampsia but apparently not for HELLP syndrome. Southern Medical Journal, 93(7), 686-91.
Martin JN, et al. Increasing Maternal Weight: a Risk Factor for Preeclampsia/eclampsia but Apparently Not for HELLP Syndrome. South Med J. 2000;93(7):686-91. PubMed PMID: 10923957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increasing maternal weight: a risk factor for preeclampsia/eclampsia but apparently not for HELLP syndrome. AU - Martin,J N,Jr AU - May,W L, AU - Rinehart,B K, AU - Martin,R W, AU - Magann,E F, PY - 2000/8/3/pubmed PY - 2000/8/29/medline PY - 2000/8/3/entrez SP - 686 EP - 91 JF - Southern medical journal JO - South Med J VL - 93 IS - 7 N2 - BACKGROUND: Maternal obesity is a risk factor for severe preeclampsia. We sought to ascertain whether a similar relationship exists between maternal weight and HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) as an atypical form of severe preeclampsia. METHODS: In this retrospective investigation, 434 patients with HELLP syndrome were assigned to one of four study groups according to maternal weight and were analyzed in relation to selected maternal and perinatal data reflective of disease severity. RESULTS: We found no significant associations between maternal weight and parameters of HELLP syndrome severity, race, delivery mode, gestational age, or perinatal outcome. Significantly associated with increasing maternal weight were maternal age, parity, admission mean arterial pressure, peak peripartum systolic blood pressures, concurrent essential hypertension, and the interval between admission and delivery. Inversely associated were eclampsia and the interval between delivery and discharge. CONCLUSIONS: Severity and complications attendant with HELLP syndrome appear unrelated to maternal weight. Paradoxically, eclampsia occurs most commonly in the lighter gravida with HELLP syndrome. SN - 0038-4348 UR - https://www.unboundmedicine.com/medline/citation/10923957/Increasing_maternal_weight:_a_risk_factor_for_preeclampsia/eclampsia_but_apparently_not_for_HELLP_syndrome_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10923957.ui DB - PRIME DP - Unbound Medicine ER -