Tags

Type your tag names separated by a space and hit enter

R(+)-8-OH-DPAT, a selective 5-HT(1A) receptor agonist, attenuated amphetamine-induced dopamine synthesis in rat striatum, but not nucleus accumbens or medial prefrontal cortex.
Brain Res. 2000 Jul 28; 872(1-2):204-7.BR

Abstract

R(+)-8-OH-DPAT (0.05, but not 0.025, 0.1, 1 mg/kg), a 5-HT(1A) receptor agonist, decreased l-3,4-dihydroxyphenylalanine (DOPA) accumulation in rat striatum following NSD-1015, an l-aromatic amino acid decarboxylase inhibitor. Amphetamine (1 mg/kg) increased striatal DOPA accumulation, an effect attenuated by R(+)-8-OH-DPAT (0.05 mg/kg). However, both amphetamine (1 mg/kg) and R(+)-8-OH-DPAT (0.05 mg/kg) decreased cortical DOPA accumulation; there were no additional decreases from their combination. Neither amphetamine (1 mg/kg), R(+)-8-OH-DPAT (0.05 mg/kg), or the combination, significantly affected DOPA accumulation in the nucleus accumbens. The significance of and possible mechanisms for these findings are discussed.

Authors+Show Affiliations

The First Floor Laboratory, Psychopharmacology Division, Departments of Psychiatry and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37212, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10924694

Citation

Kuroki, T, et al. "R(+)-8-OH-DPAT, a Selective 5-HT(1A) Receptor Agonist, Attenuated Amphetamine-induced Dopamine Synthesis in Rat Striatum, but Not Nucleus Accumbens or Medial Prefrontal Cortex." Brain Research, vol. 872, no. 1-2, 2000, pp. 204-7.
Kuroki T, Dai J, Meltzer HY, et al. R(+)-8-OH-DPAT, a selective 5-HT(1A) receptor agonist, attenuated amphetamine-induced dopamine synthesis in rat striatum, but not nucleus accumbens or medial prefrontal cortex. Brain Res. 2000;872(1-2):204-7.
Kuroki, T., Dai, J., Meltzer, H. Y., & Ichikawa, J. (2000). R(+)-8-OH-DPAT, a selective 5-HT(1A) receptor agonist, attenuated amphetamine-induced dopamine synthesis in rat striatum, but not nucleus accumbens or medial prefrontal cortex. Brain Research, 872(1-2), 204-7.
Kuroki T, et al. R(+)-8-OH-DPAT, a Selective 5-HT(1A) Receptor Agonist, Attenuated Amphetamine-induced Dopamine Synthesis in Rat Striatum, but Not Nucleus Accumbens or Medial Prefrontal Cortex. Brain Res. 2000 Jul 28;872(1-2):204-7. PubMed PMID: 10924694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - R(+)-8-OH-DPAT, a selective 5-HT(1A) receptor agonist, attenuated amphetamine-induced dopamine synthesis in rat striatum, but not nucleus accumbens or medial prefrontal cortex. AU - Kuroki,T, AU - Dai,J, AU - Meltzer,H Y, AU - Ichikawa,J, PY - 2000/8/5/pubmed PY - 2000/9/23/medline PY - 2000/8/5/entrez SP - 204 EP - 7 JF - Brain research JO - Brain Res VL - 872 IS - 1-2 N2 - R(+)-8-OH-DPAT (0.05, but not 0.025, 0.1, 1 mg/kg), a 5-HT(1A) receptor agonist, decreased l-3,4-dihydroxyphenylalanine (DOPA) accumulation in rat striatum following NSD-1015, an l-aromatic amino acid decarboxylase inhibitor. Amphetamine (1 mg/kg) increased striatal DOPA accumulation, an effect attenuated by R(+)-8-OH-DPAT (0.05 mg/kg). However, both amphetamine (1 mg/kg) and R(+)-8-OH-DPAT (0.05 mg/kg) decreased cortical DOPA accumulation; there were no additional decreases from their combination. Neither amphetamine (1 mg/kg), R(+)-8-OH-DPAT (0.05 mg/kg), or the combination, significantly affected DOPA accumulation in the nucleus accumbens. The significance of and possible mechanisms for these findings are discussed. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/10924694/R_+__8_OH_DPAT_a_selective_5_HT_1A__receptor_agonist_attenuated_amphetamine_induced_dopamine_synthesis_in_rat_striatum_but_not_nucleus_accumbens_or_medial_prefrontal_cortex_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(00)02437-9 DB - PRIME DP - Unbound Medicine ER -