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R(+)-8-OH-DPAT, a selective 5-HT(1A) receptor agonist, attenuated amphetamine-induced dopamine synthesis in rat striatum, but not nucleus accumbens or medial prefrontal cortex.
Brain Res. 2000 Jul 28; 872(1-2):204-7.BR

Abstract

R(+)-8-OH-DPAT (0.05, but not 0.025, 0.1, 1 mg/kg), a 5-HT(1A) receptor agonist, decreased l-3,4-dihydroxyphenylalanine (DOPA) accumulation in rat striatum following NSD-1015, an l-aromatic amino acid decarboxylase inhibitor. Amphetamine (1 mg/kg) increased striatal DOPA accumulation, an effect attenuated by R(+)-8-OH-DPAT (0.05 mg/kg). However, both amphetamine (1 mg/kg) and R(+)-8-OH-DPAT (0.05 mg/kg) decreased cortical DOPA accumulation; there were no additional decreases from their combination. Neither amphetamine (1 mg/kg), R(+)-8-OH-DPAT (0.05 mg/kg), or the combination, significantly affected DOPA accumulation in the nucleus accumbens. The significance of and possible mechanisms for these findings are discussed.

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Authors+Show Affiliations

Kuroki T
The First Floor Laboratory, Psychopharmacology Division, Departments of Psychiatry and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37212, USA.
Dai J
No affiliation info available
Meltzer HY
No affiliation info available
Ichikawa J
No affiliation info available

MeSH

8-Hydroxy-2-(di-n-propylamino)tetralinAmphetamineAnalysis of VarianceAnimalsCorpus StriatumDopamineDose-Response Relationship, DrugDrug Administration ScheduleInjections, SubcutaneousMaleNucleus AccumbensPrefrontal CortexRatsRats, Sprague-DawleyReceptors, SerotoninReceptors, Serotonin, 5-HT1Serotonin Receptor Agonists

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10924694

Citation

Kuroki, T, et al. "R(+)-8-OH-DPAT, a Selective 5-HT(1A) Receptor Agonist, Attenuated Amphetamine-induced Dopamine Synthesis in Rat Striatum, but Not Nucleus Accumbens or Medial Prefrontal Cortex." Brain Research, vol. 872, no. 1-2, 2000, pp. 204-7.
Kuroki T, Dai J, Meltzer HY, et al. R(+)-8-OH-DPAT, a selective 5-HT(1A) receptor agonist, attenuated amphetamine-induced dopamine synthesis in rat striatum, but not nucleus accumbens or medial prefrontal cortex. Brain Res. 2000;872(1-2):204-7.
Kuroki, T., Dai, J., Meltzer, H. Y., & Ichikawa, J. (2000). R(+)-8-OH-DPAT, a selective 5-HT(1A) receptor agonist, attenuated amphetamine-induced dopamine synthesis in rat striatum, but not nucleus accumbens or medial prefrontal cortex. Brain Research, 872(1-2), 204-7.
Kuroki T, et al. R(+)-8-OH-DPAT, a Selective 5-HT(1A) Receptor Agonist, Attenuated Amphetamine-induced Dopamine Synthesis in Rat Striatum, but Not Nucleus Accumbens or Medial Prefrontal Cortex. Brain Res. 2000 Jul 28;872(1-2):204-7. PubMed PMID: 10924694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - R(+)-8-OH-DPAT, a selective 5-HT(1A) receptor agonist, attenuated amphetamine-induced dopamine synthesis in rat striatum, but not nucleus accumbens or medial prefrontal cortex. AU - Kuroki,T, AU - Dai,J, AU - Meltzer,H Y, AU - Ichikawa,J, PY - 2000/8/5/pubmed PY - 2000/9/23/medline PY - 2000/8/5/entrez SP - 204 EP - 7 JF - Brain research JO - Brain Res VL - 872 IS - 1-2 N2 - R(+)-8-OH-DPAT (0.05, but not 0.025, 0.1, 1 mg/kg), a 5-HT(1A) receptor agonist, decreased l-3,4-dihydroxyphenylalanine (DOPA) accumulation in rat striatum following NSD-1015, an l-aromatic amino acid decarboxylase inhibitor. Amphetamine (1 mg/kg) increased striatal DOPA accumulation, an effect attenuated by R(+)-8-OH-DPAT (0.05 mg/kg). However, both amphetamine (1 mg/kg) and R(+)-8-OH-DPAT (0.05 mg/kg) decreased cortical DOPA accumulation; there were no additional decreases from their combination. Neither amphetamine (1 mg/kg), R(+)-8-OH-DPAT (0.05 mg/kg), or the combination, significantly affected DOPA accumulation in the nucleus accumbens. The significance of and possible mechanisms for these findings are discussed. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/10924694/R_+__8_OH_DPAT_a_selective_5_HT_1A__receptor_agonist_attenuated_amphetamine_induced_dopamine_synthesis_in_rat_striatum_but_not_nucleus_accumbens_or_medial_prefrontal_cortex_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(00)02437-9 DB - PRIME DP - Unbound Medicine ER -