Tags

Type your tag names separated by a space and hit enter

Characterization of the potentiation of the antinociceptive effect of diclofenac by vitamin B complex in the rat.
J Pharmacol Toxicol Methods. 1999 Oct; 42(2):73-7.JP

Abstract

The role of vitamin B complex preparations as an analgesic adjuvant is controversial. Therefore, the purpose of the present study was to characterize the potentiation of the antinociceptive effect of diclofenac by a vitamin B complex preparation and its individual components by using the pain-induced functional-impairment model in the rat (PIFIR). Pain was produced by the intraarticular injection of uric acid in the right hind limb. Oral administration of diclofenac resulted in a dose-dependent antinociceptive effect. Oral administration of a vitamin B complex preparation containing thiamine (vitamin B(1)), pyridoxine (vitamin B(6)), and cyanocobalamin (vitamin B(12)) in a 1:1:0.01 proportion did not produce any antinociception by itself, but it significantly potentiated the effect of diclofenac. Coadministration of diclofenac with either thiamine or pyridoxine resulted in an antinociceptive effect similar to that of diclofenac alone. On the other hand, coadministration of cyanocobalamin significantly increased diclofenac-induced antinociception. It is concluded that the potentiation of diclofenac-induced antinociception in the PIFIR model is due to cyanocobalamin.

Authors+Show Affiliations

Sección de Estudios de Postgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Mexico. InfectMed_2000@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10924889

Citation

Reyes-García, G, et al. "Characterization of the Potentiation of the Antinociceptive Effect of Diclofenac By Vitamin B Complex in the Rat." Journal of Pharmacological and Toxicological Methods, vol. 42, no. 2, 1999, pp. 73-7.
Reyes-García G, Medina-Santillán R, Terán-Rosales F, et al. Characterization of the potentiation of the antinociceptive effect of diclofenac by vitamin B complex in the rat. J Pharmacol Toxicol Methods. 1999;42(2):73-7.
Reyes-García, G., Medina-Santillán, R., Terán-Rosales, F., Mateos-García, E., & Castillo-Henkel, C. (1999). Characterization of the potentiation of the antinociceptive effect of diclofenac by vitamin B complex in the rat. Journal of Pharmacological and Toxicological Methods, 42(2), 73-7.
Reyes-García G, et al. Characterization of the Potentiation of the Antinociceptive Effect of Diclofenac By Vitamin B Complex in the Rat. J Pharmacol Toxicol Methods. 1999;42(2):73-7. PubMed PMID: 10924889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of the potentiation of the antinociceptive effect of diclofenac by vitamin B complex in the rat. AU - Reyes-García,G, AU - Medina-Santillán,R, AU - Terán-Rosales,F, AU - Mateos-García,E, AU - Castillo-Henkel,C, PY - 2000/8/5/pubmed PY - 2000/8/29/medline PY - 2000/8/5/entrez SP - 73 EP - 7 JF - Journal of pharmacological and toxicological methods JO - J Pharmacol Toxicol Methods VL - 42 IS - 2 N2 - The role of vitamin B complex preparations as an analgesic adjuvant is controversial. Therefore, the purpose of the present study was to characterize the potentiation of the antinociceptive effect of diclofenac by a vitamin B complex preparation and its individual components by using the pain-induced functional-impairment model in the rat (PIFIR). Pain was produced by the intraarticular injection of uric acid in the right hind limb. Oral administration of diclofenac resulted in a dose-dependent antinociceptive effect. Oral administration of a vitamin B complex preparation containing thiamine (vitamin B(1)), pyridoxine (vitamin B(6)), and cyanocobalamin (vitamin B(12)) in a 1:1:0.01 proportion did not produce any antinociception by itself, but it significantly potentiated the effect of diclofenac. Coadministration of diclofenac with either thiamine or pyridoxine resulted in an antinociceptive effect similar to that of diclofenac alone. On the other hand, coadministration of cyanocobalamin significantly increased diclofenac-induced antinociception. It is concluded that the potentiation of diclofenac-induced antinociception in the PIFIR model is due to cyanocobalamin. SN - 1056-8719 UR - https://www.unboundmedicine.com/medline/citation/10924889/Characterization_of_the_potentiation_of_the_antinociceptive_effect_of_diclofenac_by_vitamin_B_complex_in_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1056-8719(00)00045-9 DB - PRIME DP - Unbound Medicine ER -