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Antioxidants and cancers of the esophagus and gastric cardia.
Int J Cancer. 2000 Sep 01; 87(5):750-4.IJ

Abstract

Antioxidant vitamins have attracted considerable attention in previous studies of esophageal squamous-cell carcinoma, but dietary studies of adenocarcinoma of the esophagus and gastric cardia remain sparse. Treating these tumors as distinct diseases, we studied intakes of vitamin C, beta-carotene and alpha-tocopherol in a nationwide population-based case-control study in Sweden, with 185, 165, and 258 cases of esophageal adenocarcinoma, esophageal squamous-cell carcinoma, and gastric cardia adenocarcinoma, respectively, and 815 controls. Subjects with a high parallel intake of vitamin C, beta-carotene, and alpha-tocopherol showed a 40-50% decreased risk of both histological types of esophageal cancer compared with subjects with a low parallel intake. Antioxidant intake was not associated with the risk of gastric cardia adenocarcinoma. Separately, vitamin C and beta-carotene reduced the risk of esophageal cancers more than alpha-tocopherol. We found that antioxidant intake is associated with similar risk reductions for both main histological types of esophageal cancer. Our findings indicate that antioxidants do not explain the diverging incidence rates of the 2 histological types of esophageal cancer. Moreover, our data suggest that inverse associations with esophageal squamous-cell carcinoma and adenocarcinoma may be stronger among subjects under presumed higher oxidative stress due to smoking or gastroesophageal reflux, respectively. Our results may be relevant for the implementation of focused, cost-effective preventive measures.

Authors+Show Affiliations

Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden. paul.terry@mep.ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10925371

Citation

Terry, P, et al. "Antioxidants and Cancers of the Esophagus and Gastric Cardia." International Journal of Cancer, vol. 87, no. 5, 2000, pp. 750-4.
Terry P, Lagergren J, Ye W, et al. Antioxidants and cancers of the esophagus and gastric cardia. Int J Cancer. 2000;87(5):750-4.
Terry, P., Lagergren, J., Ye, W., Nyrén, O., & Wolk, A. (2000). Antioxidants and cancers of the esophagus and gastric cardia. International Journal of Cancer, 87(5), 750-4.
Terry P, et al. Antioxidants and Cancers of the Esophagus and Gastric Cardia. Int J Cancer. 2000 Sep 1;87(5):750-4. PubMed PMID: 10925371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidants and cancers of the esophagus and gastric cardia. AU - Terry,P, AU - Lagergren,J, AU - Ye,W, AU - Nyrén,O, AU - Wolk,A, PY - 2000/8/5/pubmed PY - 2000/8/19/medline PY - 2000/8/5/entrez SP - 750 EP - 4 JF - International journal of cancer JO - Int J Cancer VL - 87 IS - 5 N2 - Antioxidant vitamins have attracted considerable attention in previous studies of esophageal squamous-cell carcinoma, but dietary studies of adenocarcinoma of the esophagus and gastric cardia remain sparse. Treating these tumors as distinct diseases, we studied intakes of vitamin C, beta-carotene and alpha-tocopherol in a nationwide population-based case-control study in Sweden, with 185, 165, and 258 cases of esophageal adenocarcinoma, esophageal squamous-cell carcinoma, and gastric cardia adenocarcinoma, respectively, and 815 controls. Subjects with a high parallel intake of vitamin C, beta-carotene, and alpha-tocopherol showed a 40-50% decreased risk of both histological types of esophageal cancer compared with subjects with a low parallel intake. Antioxidant intake was not associated with the risk of gastric cardia adenocarcinoma. Separately, vitamin C and beta-carotene reduced the risk of esophageal cancers more than alpha-tocopherol. We found that antioxidant intake is associated with similar risk reductions for both main histological types of esophageal cancer. Our findings indicate that antioxidants do not explain the diverging incidence rates of the 2 histological types of esophageal cancer. Moreover, our data suggest that inverse associations with esophageal squamous-cell carcinoma and adenocarcinoma may be stronger among subjects under presumed higher oxidative stress due to smoking or gastroesophageal reflux, respectively. Our results may be relevant for the implementation of focused, cost-effective preventive measures. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/10925371/Antioxidants_and_cancers_of_the_esophagus_and_gastric_cardia_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0020-7136&date=2000&volume=87&issue=5&spage=750 DB - PRIME DP - Unbound Medicine ER -