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Current total parenteral nutrition solutions for the neonate are inadequate.
Curr Opin Clin Nutr Metab Care 2000; 3(4):299-304CO

Abstract

The amino acid requirements of the parenterally fed neonate are poorly defined. Newborn infants are at risk for amino acid deficiency and toxicity, due to lack of small intestinal metabolism and metabolic immaturity. We discuss recent evidence that identifies inadequacies of commercial amino acid solutions with respect to the balance and quantity of aromatic amino acids, and sulphur amino acids. We present data demonstrating that impaired small intestinal metabolism (or lack of first pass metabolism) alters the whole body requirement for methionine, threonine, and arginine, and discuss the potential adverse effects of excess or inadequate parenteral amino acid intake.

Authors+Show Affiliations

Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

10929677

Citation

Brunton, J A., et al. "Current Total Parenteral Nutrition Solutions for the Neonate Are Inadequate." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 3, no. 4, 2000, pp. 299-304.
Brunton JA, Ball RO, Pencharz PB. Current total parenteral nutrition solutions for the neonate are inadequate. Curr Opin Clin Nutr Metab Care. 2000;3(4):299-304.
Brunton, J. A., Ball, R. O., & Pencharz, P. B. (2000). Current total parenteral nutrition solutions for the neonate are inadequate. Current Opinion in Clinical Nutrition and Metabolic Care, 3(4), pp. 299-304.
Brunton JA, Ball RO, Pencharz PB. Current Total Parenteral Nutrition Solutions for the Neonate Are Inadequate. Curr Opin Clin Nutr Metab Care. 2000;3(4):299-304. PubMed PMID: 10929677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current total parenteral nutrition solutions for the neonate are inadequate. AU - Brunton,J A, AU - Ball,R O, AU - Pencharz,P B, PY - 2000/8/10/pubmed PY - 2001/2/28/medline PY - 2000/8/10/entrez SP - 299 EP - 304 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 3 IS - 4 N2 - The amino acid requirements of the parenterally fed neonate are poorly defined. Newborn infants are at risk for amino acid deficiency and toxicity, due to lack of small intestinal metabolism and metabolic immaturity. We discuss recent evidence that identifies inadequacies of commercial amino acid solutions with respect to the balance and quantity of aromatic amino acids, and sulphur amino acids. We present data demonstrating that impaired small intestinal metabolism (or lack of first pass metabolism) alters the whole body requirement for methionine, threonine, and arginine, and discuss the potential adverse effects of excess or inadequate parenteral amino acid intake. SN - 1363-1950 UR - https://www.unboundmedicine.com/medline/citation/10929677/Current_total_parenteral_nutrition_solutions_for_the_neonate_are_inadequate_ L2 - http://dx.doi.org/10.1097/00075197-200007000-00010 DB - PRIME DP - Unbound Medicine ER -