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Vitamin D receptor gene start codon polymorphism (FokI) and bone mineral density in healthy male subjects.
Clin Endocrinol (Oxf). 2000 Jul; 53(1):93-8.CE

Abstract

OBJECTIVE

The genetic factors determining peak bone mineral density (BMD) in men are not well characterized. Recent studies have investigated the relationship between the start codon polymorphism (SCP) of the vitamin D receptor (VDR) gene and BMD in different populations. We have now examined the relationship between SCP of the VDR gene and BMD in a group of healthy Caucasian men from the north-east of England.

SUBJECTS

Ninety-six healthy men (median age 50, range 40.0-77.0 years).

MEASUREMENTS

Analysis of the FokI genotypes of SCP of the VDR and measurements of BMD at the femoral neck and lumbar spine were performed.

RESULTS

FF, Ff and ff VDR FokI genotypes were found to have the highest, intermediate and the lowest lumbar spine BMD, respectively (Mean +/- SD, for FF 1.07 +/- 0.14, Ff 1.05 +/- 0.16 and ff 0.95 +/- 0.10 g/cm2). There was a significant difference in spine BMD between FF and ff genotypes (P < 0.05, analysis of variance [ANOVA]), but no such difference was apparent between Ff and ff (P > 0.05, ANOVA). Interestingly, there was no association between FokI polymorphism and femoral neck BMD (Mean +/- SD, for FF 0.85 +/- 0.12, Ff 0.87 +/- 0.15 and ff 0.83 +/- 0.15 g/cm2). The distribution of FokI VDR genotypes approached Hardy-Weinberg equilibrium and was similar to that reported for women from different ethnic groups, as the prevalence of FF and ff genotypes was 44% and 16%, respectively.

CONCLUSION

The study shows that in this population of healthy men there is a weak association between lumbar spine bone mineral density and FokI restriction fragment length polymorphism at the translation initiation site of the vitamin D receptor gene.

Authors+Show Affiliations

Kanan RM
Departments of Clinical Biochemistry & Metabolic Medicine, The Medical School, University of Newcastle, Newcastle upon Tyne, UK.
Varanasi SS
No affiliation info available
Francis RM
No affiliation info available
Parker L
No affiliation info available
Datta HK
No affiliation info available

MeSH

AdultAgedBone DensityCase-Control StudiesCodon, InitiatorDeoxyribonucleases, Type II Site-SpecificFemaleFemur NeckGenotypeHumansLumbar VertebraeMaleMiddle AgedPolymorphism, GeneticProspective StudiesReceptors, Calcitriol

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10931085

Citation

Kanan, R M., et al. "Vitamin D Receptor Gene Start Codon Polymorphism (FokI) and Bone Mineral Density in Healthy Male Subjects." Clinical Endocrinology, vol. 53, no. 1, 2000, pp. 93-8.
Kanan RM, Varanasi SS, Francis RM, et al. Vitamin D receptor gene start codon polymorphism (FokI) and bone mineral density in healthy male subjects. Clin Endocrinol (Oxf). 2000;53(1):93-8.
Kanan, R. M., Varanasi, S. S., Francis, R. M., Parker, L., & Datta, H. K. (2000). Vitamin D receptor gene start codon polymorphism (FokI) and bone mineral density in healthy male subjects. Clinical Endocrinology, 53(1), 93-8.
Kanan RM, et al. Vitamin D Receptor Gene Start Codon Polymorphism (FokI) and Bone Mineral Density in Healthy Male Subjects. Clin Endocrinol (Oxf). 2000;53(1):93-8. PubMed PMID: 10931085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D receptor gene start codon polymorphism (FokI) and bone mineral density in healthy male subjects. AU - Kanan,R M, AU - Varanasi,S S, AU - Francis,R M, AU - Parker,L, AU - Datta,H K, PY - 2000/8/10/pubmed PY - 2000/9/19/medline PY - 2000/8/10/entrez SP - 93 EP - 8 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 53 IS - 1 N2 - OBJECTIVE: The genetic factors determining peak bone mineral density (BMD) in men are not well characterized. Recent studies have investigated the relationship between the start codon polymorphism (SCP) of the vitamin D receptor (VDR) gene and BMD in different populations. We have now examined the relationship between SCP of the VDR gene and BMD in a group of healthy Caucasian men from the north-east of England. SUBJECTS: Ninety-six healthy men (median age 50, range 40.0-77.0 years). MEASUREMENTS: Analysis of the FokI genotypes of SCP of the VDR and measurements of BMD at the femoral neck and lumbar spine were performed. RESULTS: FF, Ff and ff VDR FokI genotypes were found to have the highest, intermediate and the lowest lumbar spine BMD, respectively (Mean +/- SD, for FF 1.07 +/- 0.14, Ff 1.05 +/- 0.16 and ff 0.95 +/- 0.10 g/cm2). There was a significant difference in spine BMD between FF and ff genotypes (P < 0.05, analysis of variance [ANOVA]), but no such difference was apparent between Ff and ff (P > 0.05, ANOVA). Interestingly, there was no association between FokI polymorphism and femoral neck BMD (Mean +/- SD, for FF 0.85 +/- 0.12, Ff 0.87 +/- 0.15 and ff 0.83 +/- 0.15 g/cm2). The distribution of FokI VDR genotypes approached Hardy-Weinberg equilibrium and was similar to that reported for women from different ethnic groups, as the prevalence of FF and ff genotypes was 44% and 16%, respectively. CONCLUSION: The study shows that in this population of healthy men there is a weak association between lumbar spine bone mineral density and FokI restriction fragment length polymorphism at the translation initiation site of the vitamin D receptor gene. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/10931085/Vitamin_D_receptor_gene_start_codon_polymorphism__FokI__and_bone_mineral_density_in_healthy_male_subjects_ DB - PRIME DP - Unbound Medicine ER -