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Gluten-dependent diabetes-related and thyroid-related autoantibodies in patients with celiac disease.

Abstract

Patients with celiac disease are at high risk of having autoimmune disorders. Moreover, untreated patients with celiac disease have been found to have a higher than expected prevalence of organ-specific autoantibodies. In a prospective study of 90 patients with celiac disease, we found that the prevalence of diabetes and thyroid-related serum antibodies was 11.1% and 14.4%, respectively. Like antiendomysium autoantibodies, these organ-specific antibodies seem to be gluten-dependent and tend to disappear during a gluten-free diet.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Clinica Pediatrica e Laboratorio di Analisi, IRCCS "Burlo Garofolo" Trieste, Trieste, Italy.

    , , , ,

    Source

    The Journal of pediatrics 137:2 2000 Aug pg 263-5

    MeSH

    Case-Control Studies
    Celiac Disease
    Child
    Comorbidity
    Diabetes Mellitus, Type 1
    Female
    Glutens
    Humans
    Italy
    Male
    Prevalence
    Prospective Studies
    Thyroiditis, Autoimmune

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    10931424

    Citation

    * When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Gluten-dependent diabetes-related and thyroid-related autoantibodies in patients with celiac disease. AU - Ventura,A, AU - Neri,E, AU - Ughi,C, AU - Leopaldi,A, AU - Città,A, AU - Not,T, PY - 2000/8/10/pubmed PY - 2000/9/23/medline PY - 2000/8/10/entrez SP - 263 EP - 5 JF - The Journal of pediatrics JO - J. Pediatr. VL - 137 IS - 2 N2 - Patients with celiac disease are at high risk of having autoimmune disorders. Moreover, untreated patients with celiac disease have been found to have a higher than expected prevalence of organ-specific autoantibodies. In a prospective study of 90 patients with celiac disease, we found that the prevalence of diabetes and thyroid-related serum antibodies was 11.1% and 14.4%, respectively. Like antiendomysium autoantibodies, these organ-specific antibodies seem to be gluten-dependent and tend to disappear during a gluten-free diet. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/10931424/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(00)63042-1 DB - PRIME DP - Unbound Medicine ER -