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Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD.
Neurology. 2000 Aug 08; 55(3):437-40.Neur

Abstract

Plasma homocysteine and cysteine levels were measured in 90 patients with PD with the MTHFR C677T (T/T) genotype. The authors found that the levels of homocysteine-a possible risk factor for vascular disease-were elevated by 60% in levodopa-treated patients with PD, with the most marked elevation occurring in patients with the T/T genotype. Cysteine levels in subjects with PD did not differ from levels in control subjects. In the T/T genotype patients, homocysteine and folate levels were inversely correlated. Increased homocysteine might be related to levodopa, MTHFR genotype, and folate in PD.

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Authors+Show Affiliations

Yasui K
Division of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan.
Kowa H
No affiliation info available
Nakaso K
No affiliation info available
Takeshima T
No affiliation info available
Nakashima K
No affiliation info available

MeSH

AgedAged, 80 and overAntiparkinson AgentsCysteineFemaleFolic AcidGenotypeHomocysteineHumansLevodopaMaleMethylenetetrahydrofolate Reductase (NADPH2)Middle AgedOxidoreductases Acting on CH-NH Group DonorsParkinson DiseasePoint Mutation

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10932284

Citation

Yasui, K, et al. "Plasma Homocysteine and MTHFR C677T Genotype in Levodopa-treated Patients With PD." Neurology, vol. 55, no. 3, 2000, pp. 437-40.
Yasui K, Kowa H, Nakaso K, et al. Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD. Neurology. 2000;55(3):437-40.
Yasui, K., Kowa, H., Nakaso, K., Takeshima, T., & Nakashima, K. (2000). Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD. Neurology, 55(3), 437-40.
Yasui K, et al. Plasma Homocysteine and MTHFR C677T Genotype in Levodopa-treated Patients With PD. Neurology. 2000 Aug 8;55(3):437-40. PubMed PMID: 10932284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD. AU - Yasui,K, AU - Kowa,H, AU - Nakaso,K, AU - Takeshima,T, AU - Nakashima,K, PY - 2000/8/10/pubmed PY - 2000/8/29/medline PY - 2000/8/10/entrez SP - 437 EP - 40 JF - Neurology JO - Neurology VL - 55 IS - 3 N2 - Plasma homocysteine and cysteine levels were measured in 90 patients with PD with the MTHFR C677T (T/T) genotype. The authors found that the levels of homocysteine-a possible risk factor for vascular disease-were elevated by 60% in levodopa-treated patients with PD, with the most marked elevation occurring in patients with the T/T genotype. Cysteine levels in subjects with PD did not differ from levels in control subjects. In the T/T genotype patients, homocysteine and folate levels were inversely correlated. Increased homocysteine might be related to levodopa, MTHFR genotype, and folate in PD. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/10932284/Plasma_homocysteine_and_MTHFR_C677T_genotype_in_levodopa_treated_patients_with_PD_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=10932284 DB - PRIME DP - Unbound Medicine ER -