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Compatibility and stability of linezolid injection admixed with three cephalosporin antibiotics.
J Am Pharm Assoc (Wash) 2000 Jul-Aug; 40(4):509-14JA

Abstract

OBJECTIVE

To evaluate the physical compatibility and chemical stability of linezolid (Zyvox-Pharmacia) 200 mg/100 mL admixed with cefazolin sodium 1 gram, ceftazidime 2 grams, and ceftriaxone sodium 1 gram for 7 days at 4 degrees C and 23 degrees C.

DESIGN

Controlled experimental trial.

SETTING

Laboratory.

INTERVENTIONS

The test samples were prepared by adding the required amount of the cephalosporin antibiotic to bags of linezolid injection 200 mg/100 mL.

MAIN OUTCOME MEASURES

Physical stability and chemical stability based on drug concentrations initially and after 1, 3, 5, and 7 days of storage at 4 degrees C and 23 degrees C protected from light.

RESULTS

All of the linezolid admixtures with cephalosporins were clear when viewed in normal fluorescent room light and with a Tyndall beam. Measured turbidity and particulate content were low and exhibited little change. The cefazolin sodium-containing samples were colorless throughout the study. The admixtures with ceftazidime and ceftriaxone sodium had a slight yellow tinge initially, and the room temperature samples became a frank yellow color after 5 days. The refrigerated samples did not change color. High-performance liquid chromatography analysis found little or no loss of linezolid in any sample stored at either temperature throughout the study. Cefazolin sodium and ceftazidime in the linezolid admixtures at 4 degrees C remained stable for 7 days, but at 23 degrees C cefazolin sodium was stable for 3 days and ceftazidime for only 24 hours before cephalosporin decomposition exceeded 10%. Ceftriaxone sodium was less stable in the admixtures; 10% loss occurred in 3 days at 4 degrees C and more than 20% loss occurred in 24 hours at 23 degrees C.

CONCLUSION

Admixtures of linezolid 200 mg/100 mL with cefazolin sodium 1 gram and ceftazidime 2 grams were physically compatible and chemically stable for at least 7 days stored at 4 degrees C protected from light and for 3 days and 1 day, respectively, at 23 degrees C protected from light. Admixtures of linezolid with ceftriaxone sodium 1 gram exhibited a rapid rate of cephalosporin loss at 23 degrees C, which precludes admixture of the two drugs.

Authors+Show Affiliations

Division of Pharmacy, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10932460

Citation

Xu, Q A., et al. "Compatibility and Stability of Linezolid Injection Admixed With Three Cephalosporin Antibiotics." Journal of the American Pharmaceutical Association (Washington,D.C. : 1996), vol. 40, no. 4, 2000, pp. 509-14.
Xu QA, Trissel LA, Williams KY. Compatibility and stability of linezolid injection admixed with three cephalosporin antibiotics. J Am Pharm Assoc (Wash). 2000;40(4):509-14.
Xu, Q. A., Trissel, L. A., & Williams, K. Y. (2000). Compatibility and stability of linezolid injection admixed with three cephalosporin antibiotics. Journal of the American Pharmaceutical Association (Washington,D.C. : 1996), 40(4), pp. 509-14.
Xu QA, Trissel LA, Williams KY. Compatibility and Stability of Linezolid Injection Admixed With Three Cephalosporin Antibiotics. J Am Pharm Assoc (Wash). 2000;40(4):509-14. PubMed PMID: 10932460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Compatibility and stability of linezolid injection admixed with three cephalosporin antibiotics. AU - Xu,Q A, AU - Trissel,L A, AU - Williams,K Y, PY - 2000/8/10/pubmed PY - 2000/9/19/medline PY - 2000/8/10/entrez SP - 509 EP - 14 JF - Journal of the American Pharmaceutical Association (Washington,D.C. : 1996) JO - J Am Pharm Assoc (Wash) VL - 40 IS - 4 N2 - OBJECTIVE: To evaluate the physical compatibility and chemical stability of linezolid (Zyvox-Pharmacia) 200 mg/100 mL admixed with cefazolin sodium 1 gram, ceftazidime 2 grams, and ceftriaxone sodium 1 gram for 7 days at 4 degrees C and 23 degrees C. DESIGN: Controlled experimental trial. SETTING: Laboratory. INTERVENTIONS: The test samples were prepared by adding the required amount of the cephalosporin antibiotic to bags of linezolid injection 200 mg/100 mL. MAIN OUTCOME MEASURES: Physical stability and chemical stability based on drug concentrations initially and after 1, 3, 5, and 7 days of storage at 4 degrees C and 23 degrees C protected from light. RESULTS: All of the linezolid admixtures with cephalosporins were clear when viewed in normal fluorescent room light and with a Tyndall beam. Measured turbidity and particulate content were low and exhibited little change. The cefazolin sodium-containing samples were colorless throughout the study. The admixtures with ceftazidime and ceftriaxone sodium had a slight yellow tinge initially, and the room temperature samples became a frank yellow color after 5 days. The refrigerated samples did not change color. High-performance liquid chromatography analysis found little or no loss of linezolid in any sample stored at either temperature throughout the study. Cefazolin sodium and ceftazidime in the linezolid admixtures at 4 degrees C remained stable for 7 days, but at 23 degrees C cefazolin sodium was stable for 3 days and ceftazidime for only 24 hours before cephalosporin decomposition exceeded 10%. Ceftriaxone sodium was less stable in the admixtures; 10% loss occurred in 3 days at 4 degrees C and more than 20% loss occurred in 24 hours at 23 degrees C. CONCLUSION: Admixtures of linezolid 200 mg/100 mL with cefazolin sodium 1 gram and ceftazidime 2 grams were physically compatible and chemically stable for at least 7 days stored at 4 degrees C protected from light and for 3 days and 1 day, respectively, at 23 degrees C protected from light. Admixtures of linezolid with ceftriaxone sodium 1 gram exhibited a rapid rate of cephalosporin loss at 23 degrees C, which precludes admixture of the two drugs. SN - 1086-5802 UR - https://www.unboundmedicine.com/medline/citation/10932460/Compatibility_and_stability_of_linezolid_injection_admixed_with_three_cephalosporin_antibiotics_ DB - PRIME DP - Unbound Medicine ER -