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Fibrinogen, other putative markers of inflammation, and weight gain in middle-aged adults--the ARIC study. Atherosclerosis Risk in Communities.
Obes Res 2000; 8(4):279-86OR

Abstract

PURPOSE

Weight gain is an important risk factor for the development of the metabolic syndrome, and inflammatory mediators are strongly associated with this syndrome. Our aim was to investigate whether inflammation predicts the development of weight gain in populations.

RESEARCH METHODS AND PROCEDURES

We investigated selected markers of inflammation in the prediction of weight gain over an approximately 3-year period in a biethnic cohort of 13,017 men and women, 45 to 64 years of age, using multiple linear and logistic regression modeling.

RESULTS

In adjusted models, those in the highest quartile of fibrinogen gained, during the first 3 years of follow-up, an estimated 0.23 kg/year more than those in the lowest quartile (p < 0.001). Adjusted odds of a large (greater than the 90th percentile) weight gain for those in the highest quartile of fibrinogen were 1.65 (95% confidence interval [CI], 1.38 to 1.97) times those in the lowest quartile. Similarly adjusted odds ratios for a large weight gain for those with high levels of white blood cell count, factor VIII, and von Willebrand factor were 1.38 (1.14 to 1.67), 1.28 (1.08 to 1.53), and 1.28 (1.08 to 1.51), respectively.

DISCUSSION

Fibrinogen and other putative markers of inflammation predict weight gain in middle-aged adults. Given the known links between the inflammatory response and intermediary metabolism and the methodological strengths of the Atherosclerosis Risk in Communities (ARIC) cohort, these findings, though without immediate clinical applicability, suggest that inflammatory processes play a role in the development of the metabolic syndrome and cardiovascular disease in part through stimulation of weight gain.

Authors+Show Affiliations

Department of Social Medicine, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10933303

Citation

Duncan, B B., et al. "Fibrinogen, Other Putative Markers of Inflammation, and Weight Gain in Middle-aged Adults--the ARIC Study. Atherosclerosis Risk in Communities." Obesity Research, vol. 8, no. 4, 2000, pp. 279-86.
Duncan BB, Schmidt MI, Chambless LE, et al. Fibrinogen, other putative markers of inflammation, and weight gain in middle-aged adults--the ARIC study. Atherosclerosis Risk in Communities. Obes Res. 2000;8(4):279-86.
Duncan, B. B., Schmidt, M. I., Chambless, L. E., Folsom, A. R., Carpenter, M., & Heiss, G. (2000). Fibrinogen, other putative markers of inflammation, and weight gain in middle-aged adults--the ARIC study. Atherosclerosis Risk in Communities. Obesity Research, 8(4), pp. 279-86.
Duncan BB, et al. Fibrinogen, Other Putative Markers of Inflammation, and Weight Gain in Middle-aged Adults--the ARIC Study. Atherosclerosis Risk in Communities. Obes Res. 2000;8(4):279-86. PubMed PMID: 10933303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fibrinogen, other putative markers of inflammation, and weight gain in middle-aged adults--the ARIC study. Atherosclerosis Risk in Communities. AU - Duncan,B B, AU - Schmidt,M I, AU - Chambless,L E, AU - Folsom,A R, AU - Carpenter,M, AU - Heiss,G, PY - 2000/8/10/pubmed PY - 2001/2/28/medline PY - 2000/8/10/entrez SP - 279 EP - 86 JF - Obesity research JO - Obes. Res. VL - 8 IS - 4 N2 - PURPOSE: Weight gain is an important risk factor for the development of the metabolic syndrome, and inflammatory mediators are strongly associated with this syndrome. Our aim was to investigate whether inflammation predicts the development of weight gain in populations. RESEARCH METHODS AND PROCEDURES: We investigated selected markers of inflammation in the prediction of weight gain over an approximately 3-year period in a biethnic cohort of 13,017 men and women, 45 to 64 years of age, using multiple linear and logistic regression modeling. RESULTS: In adjusted models, those in the highest quartile of fibrinogen gained, during the first 3 years of follow-up, an estimated 0.23 kg/year more than those in the lowest quartile (p < 0.001). Adjusted odds of a large (greater than the 90th percentile) weight gain for those in the highest quartile of fibrinogen were 1.65 (95% confidence interval [CI], 1.38 to 1.97) times those in the lowest quartile. Similarly adjusted odds ratios for a large weight gain for those with high levels of white blood cell count, factor VIII, and von Willebrand factor were 1.38 (1.14 to 1.67), 1.28 (1.08 to 1.53), and 1.28 (1.08 to 1.51), respectively. DISCUSSION: Fibrinogen and other putative markers of inflammation predict weight gain in middle-aged adults. Given the known links between the inflammatory response and intermediary metabolism and the methodological strengths of the Atherosclerosis Risk in Communities (ARIC) cohort, these findings, though without immediate clinical applicability, suggest that inflammatory processes play a role in the development of the metabolic syndrome and cardiovascular disease in part through stimulation of weight gain. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/10933303/Fibrinogen_other_putative_markers_of_inflammation_and_weight_gain_in_middle_aged_adults__the_ARIC_study__Atherosclerosis_Risk_in_Communities_ L2 - https://doi.org/10.1038/oby.2000.33 DB - PRIME DP - Unbound Medicine ER -