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Intake of fruits, vegetables, folic acid and related nutrients and risk of breast cancer in postmenopausal women.
Public Health Nutr 1998; 1(3):147-56PH

Abstract

OBJECTIVE

To determine the role of fruit and vegetable consumption and dietary intake of folic acid and related nutrients such as methionine, cysteine and alcohol in the aetiology of breast cancer.

DESIGN

Population based case-control study.

SETTING

Part of the European Community Multicentre Study on Antioxidants, Myocardial Infarction, and Cancer of the Breast (EURAMIC) in Berlin, Germany.

SUBJECTS

As part of the EURAMIC study, dietary intake data were collected in 43 postmenopausal women diagnosed with breast cancer between 1991 and 1992 in Berlin, Germany, and compared to 106 population-based controls.

RESULTS

Odds ratios (ORs) adjusted for major risk factors of breast cancer but not for total energy intake showed a non-significant inverse association between a high intake of vegetables (OR=0.76, 95% CI=0.48-1.20) and fruits (OR=0.74, 95% CI=0.48-1.15) and breast cancer. Once results were adjusted for total energy intake the associations became much weaker (vegetables: R=0.86, 95% CI=0.51-1.46; fruits: OR=0.82, 95% CI=0.51-1.32). For all nutrients, the effect of energy adjustment was more profound and the inverse associations disappeared when results were adjusted for energy intake (total folate-not energy adjusted: OR = 0.79, 95% CI=0.51-1.21; energy adjusted: OR=1.14, 95% CI=0.73-1.79; folate equivalents-not energy adjusted: OR=0.81, 95% CI=0.53-1.23; energy adjusted: OR=1.16, 95% CI=0.78-1.74; methionine-not energy adjusted: OR=0.60, 95% CI=0.35-1.03; energy adjusted: OR=1.29, 95% CI=0.76-2.19; cysteine-not energy adjusted: OR=0.52, 95% CI=0.29-0.94; energy adjusted: OR=1.22, 95% CI=0.75-1.97). Alcohol intake was inversely associated with breast cancer in a non-significant way, possibly due to the relatively low alcohol intake of the study population.

CONCLUSIONS

The results of this study do not provide firm evidence that a high intake of fruits and vegetables, folic acid, methionine or cysteine reduces the risk of getting breast cancer.

Authors+Show Affiliations

Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, 27599-7400, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

10933412

Citation

Thorand, B, et al. "Intake of Fruits, Vegetables, Folic Acid and Related Nutrients and Risk of Breast Cancer in Postmenopausal Women." Public Health Nutrition, vol. 1, no. 3, 1998, pp. 147-56.
Thorand B, Kohlmeier L, Simonsen N, et al. Intake of fruits, vegetables, folic acid and related nutrients and risk of breast cancer in postmenopausal women. Public Health Nutr. 1998;1(3):147-56.
Thorand, B., Kohlmeier, L., Simonsen, N., Croghan, C., & Thamm, M. (1998). Intake of fruits, vegetables, folic acid and related nutrients and risk of breast cancer in postmenopausal women. Public Health Nutrition, 1(3), pp. 147-56.
Thorand B, et al. Intake of Fruits, Vegetables, Folic Acid and Related Nutrients and Risk of Breast Cancer in Postmenopausal Women. Public Health Nutr. 1998;1(3):147-56. PubMed PMID: 10933412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of fruits, vegetables, folic acid and related nutrients and risk of breast cancer in postmenopausal women. AU - Thorand,B, AU - Kohlmeier,L, AU - Simonsen,N, AU - Croghan,C, AU - Thamm,M, PY - 2000/8/10/pubmed PY - 2000/9/30/medline PY - 2000/8/10/entrez SP - 147 EP - 56 JF - Public health nutrition JO - Public Health Nutr VL - 1 IS - 3 N2 - OBJECTIVE: To determine the role of fruit and vegetable consumption and dietary intake of folic acid and related nutrients such as methionine, cysteine and alcohol in the aetiology of breast cancer. DESIGN: Population based case-control study. SETTING: Part of the European Community Multicentre Study on Antioxidants, Myocardial Infarction, and Cancer of the Breast (EURAMIC) in Berlin, Germany. SUBJECTS: As part of the EURAMIC study, dietary intake data were collected in 43 postmenopausal women diagnosed with breast cancer between 1991 and 1992 in Berlin, Germany, and compared to 106 population-based controls. RESULTS: Odds ratios (ORs) adjusted for major risk factors of breast cancer but not for total energy intake showed a non-significant inverse association between a high intake of vegetables (OR=0.76, 95% CI=0.48-1.20) and fruits (OR=0.74, 95% CI=0.48-1.15) and breast cancer. Once results were adjusted for total energy intake the associations became much weaker (vegetables: R=0.86, 95% CI=0.51-1.46; fruits: OR=0.82, 95% CI=0.51-1.32). For all nutrients, the effect of energy adjustment was more profound and the inverse associations disappeared when results were adjusted for energy intake (total folate-not energy adjusted: OR = 0.79, 95% CI=0.51-1.21; energy adjusted: OR=1.14, 95% CI=0.73-1.79; folate equivalents-not energy adjusted: OR=0.81, 95% CI=0.53-1.23; energy adjusted: OR=1.16, 95% CI=0.78-1.74; methionine-not energy adjusted: OR=0.60, 95% CI=0.35-1.03; energy adjusted: OR=1.29, 95% CI=0.76-2.19; cysteine-not energy adjusted: OR=0.52, 95% CI=0.29-0.94; energy adjusted: OR=1.22, 95% CI=0.75-1.97). Alcohol intake was inversely associated with breast cancer in a non-significant way, possibly due to the relatively low alcohol intake of the study population. CONCLUSIONS: The results of this study do not provide firm evidence that a high intake of fruits and vegetables, folic acid, methionine or cysteine reduces the risk of getting breast cancer. SN - 1368-9800 UR - https://www.unboundmedicine.com/medline/citation/10933412/Intake_of_fruits_vegetables_folic_acid_and_related_nutrients_and_risk_of_breast_cancer_in_postmenopausal_women_ L2 - https://www.cambridge.org/core/product/identifier/S1368980098000251/type/journal_article DB - PRIME DP - Unbound Medicine ER -