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Diabetes, fasting blood glucose and age-related cataract: the Blue Mountains Eye Study.
Ophthalmic Epidemiol. 2000 Jun; 7(2):103-14.OE

Abstract

AIMS

To examine the relationship between diabetes and the presence of cortical, nuclear and posterior subcapsular (PSC) cataract in a defined older population, while controlling for known cataract risk factors.

METHODS

Slit-lamp and retroillumination lens photographs were taken on 3654 participants attending the population-based Blue Mountains Eye Study during 1992-94. Masked grading of the photographs was performed using the Wisconsin Cataract Grading System.

RESULTS

217 subjects (5.9% of the population) had previously diagnosed diabetes and 66 (1.8%) had diabetes diagnosed from fasting blood glucose measurements. Cortical cataract, PSC and past cataract surgery were associated with known diabetes in age-sex adjusted models. However, only PSC (odds ratio (OR) 1.8, 95% confidence interval (CI) 1.0-3.1) and past cataract surgery (OR 2.5, CI 1.5-4.2) remained statistically significantly associated with diabetes after further adjustment for other known cataract risk factors. Increasing therapy, as an index of diabetes severity (oral or insulin treatment, compared to treatment by diet alone), was associated with a markedly increased risk of PSC (OR 5.4).

CONCLUSIONS

These findings support previous research showing that diabetes has a harmful effect on the lens. The markedly increased risk for PSC may also have been reflected in the association found between diabetes and past cataract surgery. Contrary to findings from the Beaver Dam Eye Study, we found only a weak association with cortical cataract, which was not statistically significant after adjusting for other known cataract risk factors.

Authors+Show Affiliations

Departments of Ophthalmology and Public Health & Community Medicine, University of Sydney, Westmead Hospital, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10934461

Citation

Rowe, N G., et al. "Diabetes, Fasting Blood Glucose and Age-related Cataract: the Blue Mountains Eye Study." Ophthalmic Epidemiology, vol. 7, no. 2, 2000, pp. 103-14.
Rowe NG, Mitchell PG, Cumming RG, et al. Diabetes, fasting blood glucose and age-related cataract: the Blue Mountains Eye Study. Ophthalmic Epidemiol. 2000;7(2):103-14.
Rowe, N. G., Mitchell, P. G., Cumming, R. G., & Wans, J. J. (2000). Diabetes, fasting blood glucose and age-related cataract: the Blue Mountains Eye Study. Ophthalmic Epidemiology, 7(2), 103-14.
Rowe NG, et al. Diabetes, Fasting Blood Glucose and Age-related Cataract: the Blue Mountains Eye Study. Ophthalmic Epidemiol. 2000;7(2):103-14. PubMed PMID: 10934461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetes, fasting blood glucose and age-related cataract: the Blue Mountains Eye Study. AU - Rowe,N G, AU - Mitchell,P G, AU - Cumming,R G, AU - Wans,J J, PY - 2000/8/10/pubmed PY - 2000/9/2/medline PY - 2000/8/10/entrez SP - 103 EP - 14 JF - Ophthalmic epidemiology JO - Ophthalmic Epidemiol VL - 7 IS - 2 N2 - AIMS: To examine the relationship between diabetes and the presence of cortical, nuclear and posterior subcapsular (PSC) cataract in a defined older population, while controlling for known cataract risk factors. METHODS: Slit-lamp and retroillumination lens photographs were taken on 3654 participants attending the population-based Blue Mountains Eye Study during 1992-94. Masked grading of the photographs was performed using the Wisconsin Cataract Grading System. RESULTS: 217 subjects (5.9% of the population) had previously diagnosed diabetes and 66 (1.8%) had diabetes diagnosed from fasting blood glucose measurements. Cortical cataract, PSC and past cataract surgery were associated with known diabetes in age-sex adjusted models. However, only PSC (odds ratio (OR) 1.8, 95% confidence interval (CI) 1.0-3.1) and past cataract surgery (OR 2.5, CI 1.5-4.2) remained statistically significantly associated with diabetes after further adjustment for other known cataract risk factors. Increasing therapy, as an index of diabetes severity (oral or insulin treatment, compared to treatment by diet alone), was associated with a markedly increased risk of PSC (OR 5.4). CONCLUSIONS: These findings support previous research showing that diabetes has a harmful effect on the lens. The markedly increased risk for PSC may also have been reflected in the association found between diabetes and past cataract surgery. Contrary to findings from the Beaver Dam Eye Study, we found only a weak association with cortical cataract, which was not statistically significant after adjusting for other known cataract risk factors. SN - 0928-6586 UR - https://www.unboundmedicine.com/medline/citation/10934461/Diabetes_fasting_blood_glucose_and_age_related_cataract:_the_Blue_Mountains_Eye_Study_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -