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The activity of chaulmoogra acids against Mycobacterium leprae.
Am Rev Respir Dis 1975; 111(5):703-5AR

Abstract

The activity of the crude sodium salts of the fatty acids of chaulmoogra oil and of hydnocarpic and chaulmoogric acids against Mycobacterium leprae was studied in mouse footpad infection. Multiplication of the organisms was inhibited when the salts were administered intraperitoneally and subcutaneously 3 times per week, and when chaulmoogric acid was administered intraperitoneally 5 times per week in half the equivalent dose. Dihydrochaulmoogric acid was also active, whereas palmitic acid was not. Hydnocarpic acid administered intraperitoneally once per week in a dose equivalent to half that of the sodium salts of the chaulmoogra fatty acids was not effective. The demonstration that chaulmoogra fatty acids possess activity against M. leprae lends weight to our earlier suggestion that a study of compounds analogous to these acids may yield effective antimicrobial agents with a unique mechanism of action.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1093460

Citation

Levy, L. "The Activity of Chaulmoogra Acids Against Mycobacterium Leprae." The American Review of Respiratory Disease, vol. 111, no. 5, 1975, pp. 703-5.
Levy L. The activity of chaulmoogra acids against Mycobacterium leprae. Am Rev Respir Dis. 1975;111(5):703-5.
Levy, L. (1975). The activity of chaulmoogra acids against Mycobacterium leprae. The American Review of Respiratory Disease, 111(5), pp. 703-5.
Levy L. The Activity of Chaulmoogra Acids Against Mycobacterium Leprae. Am Rev Respir Dis. 1975;111(5):703-5. PubMed PMID: 1093460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The activity of chaulmoogra acids against Mycobacterium leprae. A1 - Levy,L, PY - 1975/5/1/pubmed PY - 1975/5/1/medline PY - 1975/5/1/entrez SP - 703 EP - 5 JF - The American review of respiratory disease JO - Am. Rev. Respir. Dis. VL - 111 IS - 5 N2 - The activity of the crude sodium salts of the fatty acids of chaulmoogra oil and of hydnocarpic and chaulmoogric acids against Mycobacterium leprae was studied in mouse footpad infection. Multiplication of the organisms was inhibited when the salts were administered intraperitoneally and subcutaneously 3 times per week, and when chaulmoogric acid was administered intraperitoneally 5 times per week in half the equivalent dose. Dihydrochaulmoogric acid was also active, whereas palmitic acid was not. Hydnocarpic acid administered intraperitoneally once per week in a dose equivalent to half that of the sodium salts of the chaulmoogra fatty acids was not effective. The demonstration that chaulmoogra fatty acids possess activity against M. leprae lends weight to our earlier suggestion that a study of compounds analogous to these acids may yield effective antimicrobial agents with a unique mechanism of action. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/1093460/The_activity_of_chaulmoogra_acids_against_Mycobacterium_leprae_ L2 - http://www.atsjournals.org/doi/full/10.1164/arrd.1975.111.5.703?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -