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Relation between lipoprotein (a) and in vitro oxidation of apolipoprotein B-containing lipoproteins.
Clin Biochem. 2000 Jun; 33(4):303-9.CB

Abstract

OBJECTIVES

To assess the relationship between lipoprotein (a) [Lp (a)] and lipoprotein oxidation in patients with coronary artery disease (CAD).

DESIGN AND METHODS

Oxidation of apolipoprotein (apo)B-containing lipoproteins, vitamin E, carotenoids, lipid-lipoprotein levels were determined in 171 CAD and 70 non-CAD subjects.

RESULTS

In CAD patients with Lp (a) concentrations >/= 30 mg/dL; total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA), and apo B levels were significantly higher and lag-time and age were significantly lower than those of CAD patients with Lp (a) concentrations < 30 mg/dL. In non-CAD subjects with Lp (a) concentrations >/= 30 mg/dL; TC, LDL-C, and vitamin E levels were significantly higher and lag-time was significantly lower than those of non-CAD subjects with Lp (a) concentrations < 30 mg/dL. In CAD patients, Lp (a) correlated negatively with lag-time and positively with MDA levels. Lp (a) correlated negatively with lag-time and vitamin E levels in non-CAD subjects.

CONCLUSIONS

We have shown that plasma apo B-containing lipoproteins of both CAD and non-CAD subjects with Lp (a) levels >/= 30 mg/dL are more susceptible to in vitro oxidative modification than those of subjects with Lp (a) levels < 30 mg/dL. The relationship between Lp (a) and enhanced susceptibility of apo B-containing lipoproteins to oxidation, appears to support routine investigation of Lp (a).

Authors+Show Affiliations

Department of Biochemistry, Medical Faculty of Uludağ University, Bursa, Turkey. akinserdar@superonline.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10936590

Citation

Serdar, Z, et al. "Relation Between Lipoprotein (a) and in Vitro Oxidation of Apolipoprotein B-containing Lipoproteins." Clinical Biochemistry, vol. 33, no. 4, 2000, pp. 303-9.
Serdar Z, Sarandöl E, Dirican M, et al. Relation between lipoprotein (a) and in vitro oxidation of apolipoprotein B-containing lipoproteins. Clin Biochem. 2000;33(4):303-9.
Serdar, Z., Sarandöl, E., Dirican, M., Yeşilbursa, D., Serdar, A., & Tokullugil, A. (2000). Relation between lipoprotein (a) and in vitro oxidation of apolipoprotein B-containing lipoproteins. Clinical Biochemistry, 33(4), 303-9.
Serdar Z, et al. Relation Between Lipoprotein (a) and in Vitro Oxidation of Apolipoprotein B-containing Lipoproteins. Clin Biochem. 2000;33(4):303-9. PubMed PMID: 10936590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation between lipoprotein (a) and in vitro oxidation of apolipoprotein B-containing lipoproteins. AU - Serdar,Z, AU - Sarandöl,E, AU - Dirican,M, AU - Yeşilbursa,D, AU - Serdar,A, AU - Tokullugil,A, PY - 2000/8/11/pubmed PY - 2000/10/7/medline PY - 2000/8/11/entrez SP - 303 EP - 9 JF - Clinical biochemistry JO - Clin Biochem VL - 33 IS - 4 N2 - OBJECTIVES: To assess the relationship between lipoprotein (a) [Lp (a)] and lipoprotein oxidation in patients with coronary artery disease (CAD). DESIGN AND METHODS: Oxidation of apolipoprotein (apo)B-containing lipoproteins, vitamin E, carotenoids, lipid-lipoprotein levels were determined in 171 CAD and 70 non-CAD subjects. RESULTS: In CAD patients with Lp (a) concentrations >/= 30 mg/dL; total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA), and apo B levels were significantly higher and lag-time and age were significantly lower than those of CAD patients with Lp (a) concentrations < 30 mg/dL. In non-CAD subjects with Lp (a) concentrations >/= 30 mg/dL; TC, LDL-C, and vitamin E levels were significantly higher and lag-time was significantly lower than those of non-CAD subjects with Lp (a) concentrations < 30 mg/dL. In CAD patients, Lp (a) correlated negatively with lag-time and positively with MDA levels. Lp (a) correlated negatively with lag-time and vitamin E levels in non-CAD subjects. CONCLUSIONS: We have shown that plasma apo B-containing lipoproteins of both CAD and non-CAD subjects with Lp (a) levels >/= 30 mg/dL are more susceptible to in vitro oxidative modification than those of subjects with Lp (a) levels < 30 mg/dL. The relationship between Lp (a) and enhanced susceptibility of apo B-containing lipoproteins to oxidation, appears to support routine investigation of Lp (a). SN - 0009-9120 UR - https://www.unboundmedicine.com/medline/citation/10936590/Relation_between_lipoprotein__a__and_in_vitro_oxidation_of_apolipoprotein_B_containing_lipoproteins_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(00)00079-5 DB - PRIME DP - Unbound Medicine ER -