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Post-exposure prophylaxis with purified vero cell rabies vaccine during pregnancy--safety and immunogenicity.
J Commun Dis. 1999 Dec; 31(4):229-36.JC

Abstract

This study was conducted with the main objective of determining the safety and immunogenicity of purified vero cell rabies vaccine (PVRV) during pregnancy. Twenty nine pregnant women exposed to rabies were vaccinated with PVRV as per the Essen regimen advocated by World Health Organization. None of the women experienced any adverse side effects to the vaccine. The intrauterine growth and development monitored by ultrasound examination was found to be normal and the outcome of pregnancy was satisfactory. There were no congenital anomalies in any of the infants born and they were healthy and had normal growth and development during the one year follow-up period. The rabies neutralizing antibody titers from day 14 to day 365 following vaccination in these women was adequate and well above the minimum protective level of 0.5 iu/ml of serum. Protective levels of antibodies were also present in serum of some of the babies tested, for up to 3 months of age. The mothers and infants followed for one year period were doing well at the end of the study period. Consequently, PVRV was found safe and immunogenically efficacious during pregnancy.

Authors+Show Affiliations

Kempe Gowds Institute of Medical Sciences, Bangalore.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10937299

Citation

Sudarshan, M K., et al. "Post-exposure Prophylaxis With Purified Vero Cell Rabies Vaccine During Pregnancy--safety and Immunogenicity." The Journal of Communicable Diseases, vol. 31, no. 4, 1999, pp. 229-36.
Sudarshan MK, Madhusudana SN, Mahendra BJ. Post-exposure prophylaxis with purified vero cell rabies vaccine during pregnancy--safety and immunogenicity. J Commun Dis. 1999;31(4):229-36.
Sudarshan, M. K., Madhusudana, S. N., & Mahendra, B. J. (1999). Post-exposure prophylaxis with purified vero cell rabies vaccine during pregnancy--safety and immunogenicity. The Journal of Communicable Diseases, 31(4), 229-36.
Sudarshan MK, Madhusudana SN, Mahendra BJ. Post-exposure Prophylaxis With Purified Vero Cell Rabies Vaccine During Pregnancy--safety and Immunogenicity. J Commun Dis. 1999;31(4):229-36. PubMed PMID: 10937299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Post-exposure prophylaxis with purified vero cell rabies vaccine during pregnancy--safety and immunogenicity. AU - Sudarshan,M K, AU - Madhusudana,S N, AU - Mahendra,B J, PY - 2000/8/11/pubmed PY - 2000/9/2/medline PY - 2000/8/11/entrez SP - 229 EP - 36 JF - The Journal of communicable diseases JO - J Commun Dis VL - 31 IS - 4 N2 - This study was conducted with the main objective of determining the safety and immunogenicity of purified vero cell rabies vaccine (PVRV) during pregnancy. Twenty nine pregnant women exposed to rabies were vaccinated with PVRV as per the Essen regimen advocated by World Health Organization. None of the women experienced any adverse side effects to the vaccine. The intrauterine growth and development monitored by ultrasound examination was found to be normal and the outcome of pregnancy was satisfactory. There were no congenital anomalies in any of the infants born and they were healthy and had normal growth and development during the one year follow-up period. The rabies neutralizing antibody titers from day 14 to day 365 following vaccination in these women was adequate and well above the minimum protective level of 0.5 iu/ml of serum. Protective levels of antibodies were also present in serum of some of the babies tested, for up to 3 months of age. The mothers and infants followed for one year period were doing well at the end of the study period. Consequently, PVRV was found safe and immunogenically efficacious during pregnancy. SN - 0019-5138 UR - https://www.unboundmedicine.com/medline/citation/10937299/Post_exposure_prophylaxis_with_purified_vero_cell_rabies_vaccine_during_pregnancy__safety_and_immunogenicity_ L2 - http://www.diseaseinfosearch.org/result/6131 DB - PRIME DP - Unbound Medicine ER -