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Effect of acarbose on insulin sensitivity in elderly patients with diabetes.
Diabetes Care 2000; 23(8):1162-7DC

Abstract

OBJECTIVE

To study the effect of acarbose, an alpha-glucosidase inhibitor, on insulin release and insulin sensitivity in elderly patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS

Elderly patients with type 2 diabetes were randomly treated in a double-blind fashion with placebo (n = 23) or acarbose (n = 22) for 12 months. Before and after randomization, subjects underwent a meal tolerance test and a hyperglycemic glucose clamp study designed to measure insulin release and sensitivity.

RESULTS

After 12 months of therapy there was a significant difference in the change in fasting plasma glucose levels (0.2 +/- 0.3 vs. -0.5 +/- 0.2 mmol/l, placebo vs. acarbose group, respectively; P < 0.05) and in incremental postprandial glucose values (-0.4 +/- 0.6 vs. -3.5 +/- 0.6 mmol/l, placebo vs. acarbose group, P < 0.001) between groups. There was a significant difference in the change in HbA(1c) values in response to treatment (0.4 +/- 0.2 vs. -0.4 +/- 0.1%, placebo vs. acarbose group, P < 0.01). The change in fasting insulin in response to treatment (-2 +/- 2 vs. -13 +/- 4 pmol/l, placebo vs. acarbose group, P < 0.05) and incremental postprandial insulin responses (-89 +/- 26 vs. -271 +/- 59 pmol/l, placebo vs. acarbose group, P < 0.01) was also significantly different between groups. During the hyperglycemic clamps, glucose and insulin values were similar in both groups before and after therapy However, there was a significant difference in the change in insulin sensitivity in response to treatment between the placebo and the acarbose groups (0.001 +/- 0.001 vs. 0.004 +/- 0.001 mg/kg x min(-1) [pmol/l](-1), respectively, P < 0.05)

CONCLUSIONS

Acarbose increases insulin sensitivity but not insulin release in elderly patients with diabetes.

Authors+Show Affiliations

Department of Medicine, University of British Columbia, Vancouver, Canada. gmeneill@vanhosp.bc.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10937515

Citation

Meneilly, G S., et al. "Effect of Acarbose On Insulin Sensitivity in Elderly Patients With Diabetes." Diabetes Care, vol. 23, no. 8, 2000, pp. 1162-7.
Meneilly GS, Ryan EA, Radziuk J, et al. Effect of acarbose on insulin sensitivity in elderly patients with diabetes. Diabetes Care. 2000;23(8):1162-7.
Meneilly, G. S., Ryan, E. A., Radziuk, J., Lau, D. C., Yale, J. F., Morais, J., ... Elahi, D. (2000). Effect of acarbose on insulin sensitivity in elderly patients with diabetes. Diabetes Care, 23(8), pp. 1162-7.
Meneilly GS, et al. Effect of Acarbose On Insulin Sensitivity in Elderly Patients With Diabetes. Diabetes Care. 2000;23(8):1162-7. PubMed PMID: 10937515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of acarbose on insulin sensitivity in elderly patients with diabetes. AU - Meneilly,G S, AU - Ryan,E A, AU - Radziuk,J, AU - Lau,D C, AU - Yale,J F, AU - Morais,J, AU - Chiasson,J L, AU - Rabasa-Lhoret,R, AU - Maheux,P, AU - Tessier,D, AU - Wolever,T, AU - Josse,R G, AU - Elahi,D, PY - 2000/8/11/pubmed PY - 2001/2/28/medline PY - 2000/8/11/entrez SP - 1162 EP - 7 JF - Diabetes care JO - Diabetes Care VL - 23 IS - 8 N2 - OBJECTIVE: To study the effect of acarbose, an alpha-glucosidase inhibitor, on insulin release and insulin sensitivity in elderly patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: Elderly patients with type 2 diabetes were randomly treated in a double-blind fashion with placebo (n = 23) or acarbose (n = 22) for 12 months. Before and after randomization, subjects underwent a meal tolerance test and a hyperglycemic glucose clamp study designed to measure insulin release and sensitivity. RESULTS: After 12 months of therapy there was a significant difference in the change in fasting plasma glucose levels (0.2 +/- 0.3 vs. -0.5 +/- 0.2 mmol/l, placebo vs. acarbose group, respectively; P < 0.05) and in incremental postprandial glucose values (-0.4 +/- 0.6 vs. -3.5 +/- 0.6 mmol/l, placebo vs. acarbose group, P < 0.001) between groups. There was a significant difference in the change in HbA(1c) values in response to treatment (0.4 +/- 0.2 vs. -0.4 +/- 0.1%, placebo vs. acarbose group, P < 0.01). The change in fasting insulin in response to treatment (-2 +/- 2 vs. -13 +/- 4 pmol/l, placebo vs. acarbose group, P < 0.05) and incremental postprandial insulin responses (-89 +/- 26 vs. -271 +/- 59 pmol/l, placebo vs. acarbose group, P < 0.01) was also significantly different between groups. During the hyperglycemic clamps, glucose and insulin values were similar in both groups before and after therapy However, there was a significant difference in the change in insulin sensitivity in response to treatment between the placebo and the acarbose groups (0.001 +/- 0.001 vs. 0.004 +/- 0.001 mg/kg x min(-1) [pmol/l](-1), respectively, P < 0.05) CONCLUSIONS: Acarbose increases insulin sensitivity but not insulin release in elderly patients with diabetes. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/10937515/Effect_of_acarbose_on_insulin_sensitivity_in_elderly_patients_with_diabetes_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=10937515 DB - PRIME DP - Unbound Medicine ER -