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Psychosocial stress and HPA functioning: no evidence for a reduced resilience in healthy elderly men.
Stress 2000; 3(3):229-40S

Abstract

In order to investigate if HPA functioning is altered with age, the present study was conducted. Fifteen healthy elderly men (60-76 years; mean age 66.5 +/- 1.48 yrs.) and 12 younger adults (20-29 years; mean age 25.6 +/- 0.77 yrs.) collected salivary free cortisol profiles after awakening for basal HPA activity. Then, all subjects were exposed to the "Trier Social Stress Test" (TSST). This psychosocial stress protocol consists of a free speech and a mental arithmetic task of 13 minutes duration performed in front of an audience. Beside the assessment of endocrine and cardiovascular responses to the stressful task ratings of depression, mood and perceived stressfulness were obtained. Results show that younger and elderly men had similar morning cortisol profiles after awakening with both groups showing the expected rise after awakening (P=0.004). The TSST induced significant increases in ACTH, total plasma cortisol, saliva free cortisol, and heart rates (all P<0.0001). Regardless of age, both age groups showed comparable endocrine response patterns when confronted with the stressor. However, cardiovascular responses were significantly higher in younger men compared to elderly men (P=0.03). Catecholamine data revealed significant norepinephrine and epinephrine increases due to the stressor (both P<0.0001) with a trend toward elevated norepinephrine levels in elderly men (P=0.058). In sum, the investigated basal and response parameters of HPA functioning neither support the idea of a reduced resilience in healthy aged humans nor do they appear to strengthen assumptions derived from the so called "glucocorticoid cascade hypothesis".

Authors+Show Affiliations

Center for Psychobiological and Psychosomatic Research, University of Trier, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10938584

Citation

Kudielka, B M., et al. "Psychosocial Stress and HPA Functioning: No Evidence for a Reduced Resilience in Healthy Elderly Men." Stress (Amsterdam, Netherlands), vol. 3, no. 3, 2000, pp. 229-40.
Kudielka BM, Schmidt-Reinwald AK, Hellhammer DH, et al. Psychosocial stress and HPA functioning: no evidence for a reduced resilience in healthy elderly men. Stress. 2000;3(3):229-40.
Kudielka, B. M., Schmidt-Reinwald, A. K., Hellhammer, D. H., Schürmeyer, T., & Kirschbaum, C. (2000). Psychosocial stress and HPA functioning: no evidence for a reduced resilience in healthy elderly men. Stress (Amsterdam, Netherlands), 3(3), pp. 229-40.
Kudielka BM, et al. Psychosocial Stress and HPA Functioning: No Evidence for a Reduced Resilience in Healthy Elderly Men. Stress. 2000;3(3):229-40. PubMed PMID: 10938584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychosocial stress and HPA functioning: no evidence for a reduced resilience in healthy elderly men. AU - Kudielka,B M, AU - Schmidt-Reinwald,A K, AU - Hellhammer,D H, AU - Schürmeyer,T, AU - Kirschbaum,C, PY - 2000/8/12/pubmed PY - 2000/9/23/medline PY - 2000/8/12/entrez SP - 229 EP - 40 JF - Stress (Amsterdam, Netherlands) JO - Stress VL - 3 IS - 3 N2 - In order to investigate if HPA functioning is altered with age, the present study was conducted. Fifteen healthy elderly men (60-76 years; mean age 66.5 +/- 1.48 yrs.) and 12 younger adults (20-29 years; mean age 25.6 +/- 0.77 yrs.) collected salivary free cortisol profiles after awakening for basal HPA activity. Then, all subjects were exposed to the "Trier Social Stress Test" (TSST). This psychosocial stress protocol consists of a free speech and a mental arithmetic task of 13 minutes duration performed in front of an audience. Beside the assessment of endocrine and cardiovascular responses to the stressful task ratings of depression, mood and perceived stressfulness were obtained. Results show that younger and elderly men had similar morning cortisol profiles after awakening with both groups showing the expected rise after awakening (P=0.004). The TSST induced significant increases in ACTH, total plasma cortisol, saliva free cortisol, and heart rates (all P<0.0001). Regardless of age, both age groups showed comparable endocrine response patterns when confronted with the stressor. However, cardiovascular responses were significantly higher in younger men compared to elderly men (P=0.03). Catecholamine data revealed significant norepinephrine and epinephrine increases due to the stressor (both P<0.0001) with a trend toward elevated norepinephrine levels in elderly men (P=0.058). In sum, the investigated basal and response parameters of HPA functioning neither support the idea of a reduced resilience in healthy aged humans nor do they appear to strengthen assumptions derived from the so called "glucocorticoid cascade hypothesis". SN - 1025-3890 UR - https://www.unboundmedicine.com/medline/citation/10938584/Psychosocial_stress_and_HPA_functioning:_no_evidence_for_a_reduced_resilience_in_healthy_elderly_men_ L2 - http://www.tandfonline.com/doi/full/10.3109/10253890009001127 DB - PRIME DP - Unbound Medicine ER -