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Insulin biosynthesis in isolated pancreatic islets of fetal and newborn rats.
Diabetes. 1975 Apr; 24(4):373-7.D

Abstract

The effect of glucose and glucose plus glucagon on the incorporation of H-3-L-leucine into proinsulin and insulin was examined in isolated islets of twenty-one-day old fetal and five- and ten-day old newborn rats. Maximal stimulation of (pro-) insulin biosynthesis was achieved with 100 mg. per cent of glucose in isolated islets of twenty-one-day old fetal rats. No additional effect was observed with 300 mg. per cent of glucose. On the other hand, in islets of five- and ten-day old newborn rats the incorporation of H-3-L-leucine into proinsulin and insulin was gradually augmented by glucose up to concentrations of 300 mg. per cent. Addition of glucagon to the various glucose concentrations only enhanced the synthesis of insulin in ten-day old newborn islets, whereas it had no effect on the islets of the younger age groups. The results show a different pattern of insulin biosyntheses in fetal and newborn islets, which may be related to the varied plasma glucose concentrations of the perinatal period.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

1093913

Citation

Heinze, E, et al. "Insulin Biosynthesis in Isolated Pancreatic Islets of Fetal and Newborn Rats." Diabetes, vol. 24, no. 4, 1975, pp. 373-7.
Heinze E, Schatz H, Nierle C, et al. Insulin biosynthesis in isolated pancreatic islets of fetal and newborn rats. Diabetes. 1975;24(4):373-7.
Heinze, E., Schatz, H., Nierle, C., & Pfeiffer, E. F. (1975). Insulin biosynthesis in isolated pancreatic islets of fetal and newborn rats. Diabetes, 24(4), 373-7.
Heinze E, et al. Insulin Biosynthesis in Isolated Pancreatic Islets of Fetal and Newborn Rats. Diabetes. 1975;24(4):373-7. PubMed PMID: 1093913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin biosynthesis in isolated pancreatic islets of fetal and newborn rats. AU - Heinze,E, AU - Schatz,H, AU - Nierle,C, AU - Pfeiffer,E F, PY - 1975/4/1/pubmed PY - 1975/4/1/medline PY - 1975/4/1/entrez SP - 373 EP - 7 JF - Diabetes JO - Diabetes VL - 24 IS - 4 N2 - The effect of glucose and glucose plus glucagon on the incorporation of H-3-L-leucine into proinsulin and insulin was examined in isolated islets of twenty-one-day old fetal and five- and ten-day old newborn rats. Maximal stimulation of (pro-) insulin biosynthesis was achieved with 100 mg. per cent of glucose in isolated islets of twenty-one-day old fetal rats. No additional effect was observed with 300 mg. per cent of glucose. On the other hand, in islets of five- and ten-day old newborn rats the incorporation of H-3-L-leucine into proinsulin and insulin was gradually augmented by glucose up to concentrations of 300 mg. per cent. Addition of glucagon to the various glucose concentrations only enhanced the synthesis of insulin in ten-day old newborn islets, whereas it had no effect on the islets of the younger age groups. The results show a different pattern of insulin biosyntheses in fetal and newborn islets, which may be related to the varied plasma glucose concentrations of the perinatal period. SN - 0012-1797 UR - https://www.unboundmedicine.com/medline/citation/1093913/Insulin_biosynthesis_in_isolated_pancreatic_islets_of_fetal_and_newborn_rats_ L2 - https://diabetesjournals.org/diabetes/article-lookup/doi/10.2337/diab.24.4.373 DB - PRIME DP - Unbound Medicine ER -