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Phenolic acids protect low density lipoproteins from peroxynitrite-mediated modification in vitro.
Redox Rep. 2000; 5(2-3):124-5.RR

Abstract

The role of reactive nitrogen species, such as peroxynitrite, in atherogenesis and the protective effect of dietary phenolic compounds are not yet understood. In this study, we sought firstly to determine whether phenolic acids become nitrated by peroxynitrite and then whether phenolic acid nitration can prevent consumption of gamma-tocopherol and thus enhance the resistance of LDL to oxidation by peroxynitrite. Coumaric acid was found to be readily nitrated by peroxynitrite and it also demonstrated a protective effect on y-tocopherol. Of greater significance was its potent inhibition of lipid peroxidation which was equal to that of caffeic acid.

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Authors+Show Affiliations

Morton LW
Department of Medicine, The University of Western Australia, Perth, Australia.
Croft KD
No affiliation info available
Puddey IB
No affiliation info available
Byrne L
No affiliation info available

MeSH

Caffeic AcidsCoumaric AcidsHumansKineticsLipoproteins, LDLMolsidomineNitratesNitric Oxide DonorsOxidantsVitamin E

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10939290

Citation

Morton, L W., et al. "Phenolic Acids Protect Low Density Lipoproteins From Peroxynitrite-mediated Modification in Vitro." Redox Report : Communications in Free Radical Research, vol. 5, no. 2-3, 2000, pp. 124-5.
Morton LW, Croft KD, Puddey IB, et al. Phenolic acids protect low density lipoproteins from peroxynitrite-mediated modification in vitro. Redox Rep. 2000;5(2-3):124-5.
Morton, L. W., Croft, K. D., Puddey, I. B., & Byrne, L. (2000). Phenolic acids protect low density lipoproteins from peroxynitrite-mediated modification in vitro. Redox Report : Communications in Free Radical Research, 5(2-3), 124-5.
Morton LW, et al. Phenolic Acids Protect Low Density Lipoproteins From Peroxynitrite-mediated Modification in Vitro. Redox Rep. 2000;5(2-3):124-5. PubMed PMID: 10939290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phenolic acids protect low density lipoproteins from peroxynitrite-mediated modification in vitro. AU - Morton,L W, AU - Croft,K D, AU - Puddey,I B, AU - Byrne,L, PY - 2000/8/12/pubmed PY - 2001/2/28/medline PY - 2000/8/12/entrez SP - 124 EP - 5 JF - Redox report : communications in free radical research JO - Redox Rep VL - 5 IS - 2-3 N2 - The role of reactive nitrogen species, such as peroxynitrite, in atherogenesis and the protective effect of dietary phenolic compounds are not yet understood. In this study, we sought firstly to determine whether phenolic acids become nitrated by peroxynitrite and then whether phenolic acid nitration can prevent consumption of gamma-tocopherol and thus enhance the resistance of LDL to oxidation by peroxynitrite. Coumaric acid was found to be readily nitrated by peroxynitrite and it also demonstrated a protective effect on y-tocopherol. Of greater significance was its potent inhibition of lipid peroxidation which was equal to that of caffeic acid. SN - 1351-0002 UR - https://www.unboundmedicine.com/medline/citation/10939290/Phenolic_acids_protect_low_density_lipoproteins_from_peroxynitrite_mediated_modification_in_vitro_ L2 - https://www.tandfonline.com/doi/full/10.1179/135100000101535429 DB - PRIME DP - Unbound Medicine ER -