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Cellular copper transport and metabolism.
Annu Rev Nutr. 2000; 20:291-310.AR

Abstract

The transport and cellular metabolism of Cu depends on a series of membrane proteins and smaller soluble peptides that comprise a functionally integrated system for maintaining cellular Cu homeostasis. Inward transport across the plasma membrane appears to be a function of integral membrane proteins that form the channels that select Cu ions for passage. Two membrane-bound Cu-transporting ATPase enzymes, ATP7A and ATP7B, the products of the Menkes and Wilson disease genes, respectively, catalyze an ATP-dependent transfer of Cu to intracellular compartments or expel Cu from the cell. ATP7A and ATP7B work in concert with a series of smaller peptides, the copper chaperones, that exchange Cu at the ATPase sites or incorporate the Cu directly into the structure of Cu-dependent enzymes such as cytochrome c oxidase and Cu, Zn superoxide dismutase. These mechanisms come into play in response to a high influx of Cu or during the course of normal Cu metabolism.

Authors+Show Affiliations

Department of Biochemistry and Biophysics and the Faculty of Nutrition, Texas A&M University, College Station, Texas 77843-2128, USA. eharris@tamu.edu

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

10940336

Citation

Harris, E D.. "Cellular Copper Transport and Metabolism." Annual Review of Nutrition, vol. 20, 2000, pp. 291-310.
Harris ED. Cellular copper transport and metabolism. Annu Rev Nutr. 2000;20:291-310.
Harris, E. D. (2000). Cellular copper transport and metabolism. Annual Review of Nutrition, 20, 291-310.
Harris ED. Cellular Copper Transport and Metabolism. Annu Rev Nutr. 2000;20:291-310. PubMed PMID: 10940336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cellular copper transport and metabolism. A1 - Harris,E D, PY - 2000/8/15/pubmed PY - 2001/2/28/medline PY - 2000/8/15/entrez SP - 291 EP - 310 JF - Annual review of nutrition JO - Annu Rev Nutr VL - 20 N2 - The transport and cellular metabolism of Cu depends on a series of membrane proteins and smaller soluble peptides that comprise a functionally integrated system for maintaining cellular Cu homeostasis. Inward transport across the plasma membrane appears to be a function of integral membrane proteins that form the channels that select Cu ions for passage. Two membrane-bound Cu-transporting ATPase enzymes, ATP7A and ATP7B, the products of the Menkes and Wilson disease genes, respectively, catalyze an ATP-dependent transfer of Cu to intracellular compartments or expel Cu from the cell. ATP7A and ATP7B work in concert with a series of smaller peptides, the copper chaperones, that exchange Cu at the ATPase sites or incorporate the Cu directly into the structure of Cu-dependent enzymes such as cytochrome c oxidase and Cu, Zn superoxide dismutase. These mechanisms come into play in response to a high influx of Cu or during the course of normal Cu metabolism. SN - 0199-9885 UR - https://www.unboundmedicine.com/medline/citation/10940336/Cellular_copper_transport_and_metabolism_ L2 - https://arjournals.annualreviews.org/doi/10.1146/annurev.nutr.20.1.291?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -