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Long-term feeding of dietary oils alters lipid metabolism, lipid peroxidation, and antioxidant enzyme activities in a teleost (Anabas testudineus Bloch).
Lipids. 2000 Jul; 35(7):757-62.L

Abstract

Anabas testudineus (climbing perch), average body weight 21+/-1 g, were maintained in culture tanks and fed a 35% protein feed plus an additional supplementation of three dietary oils (20% each of coconut oil, palm oil, or cod liver oil). Body weight gain was similar among all groups. However, several hepatic lipogenic enzymes such as malic enzyme (ME), NADP-isocitrate dehydrogenase (ICDH), glucose 6-phosphate dehydrogenase (G6PDH), 6-phosphogluconate dehydrogenase (6PGDH) and beta-hydroxy-1-methyl glutaryl CoA reductase (HMG CoA reductase) were assayed, and they responded differently. Hepatic ME and G6PDH activities showed a significant decrease in the coconut oil and palm oil groups, but there was no significant change in ICDH activity. The 6PGDH activities were reduced, whereas HMG CoA reductase activity was increased in the palm oil-treated group. Cholesterol synthesis in the liver and muscle increased in the palm oil-treated group, but liver phospholipids did not show any significant change in fish supplemented with oils rich in saturated fatty acids. Triacylglycerol and free fatty acid concentrations were high in the coconut oil- and palm oil-supplemented groups. Lipid peroxidation products such as thiobarbituric acid-reactive substances and conjugated dienes decreased in the same two groups. Antioxidant potential was high in all groups as evidenced by increased activity of superoxide dismutase, glutathione peroxidase, and glutathione content. The results of this study indicate that in fish, dietary lipids depress hepatic lipogenic activity as well as lipid peroxidation products by maintaining high levels of antioxidant enzymes.

Authors+Show Affiliations

Endocrinology and Biochemistry Division, Department of Zoology, University of Kerala, Kariavattom, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10941876

Citation

Varghese, S, and O V. Oommen. "Long-term Feeding of Dietary Oils Alters Lipid Metabolism, Lipid Peroxidation, and Antioxidant Enzyme Activities in a Teleost (Anabas Testudineus Bloch)." Lipids, vol. 35, no. 7, 2000, pp. 757-62.
Varghese S, Oommen OV. Long-term feeding of dietary oils alters lipid metabolism, lipid peroxidation, and antioxidant enzyme activities in a teleost (Anabas testudineus Bloch). Lipids. 2000;35(7):757-62.
Varghese, S., & Oommen, O. V. (2000). Long-term feeding of dietary oils alters lipid metabolism, lipid peroxidation, and antioxidant enzyme activities in a teleost (Anabas testudineus Bloch). Lipids, 35(7), 757-62.
Varghese S, Oommen OV. Long-term Feeding of Dietary Oils Alters Lipid Metabolism, Lipid Peroxidation, and Antioxidant Enzyme Activities in a Teleost (Anabas Testudineus Bloch). Lipids. 2000;35(7):757-62. PubMed PMID: 10941876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term feeding of dietary oils alters lipid metabolism, lipid peroxidation, and antioxidant enzyme activities in a teleost (Anabas testudineus Bloch). AU - Varghese,S, AU - Oommen,O V, PY - 2000/8/15/pubmed PY - 2001/2/28/medline PY - 2000/8/15/entrez SP - 757 EP - 62 JF - Lipids JO - Lipids VL - 35 IS - 7 N2 - Anabas testudineus (climbing perch), average body weight 21+/-1 g, were maintained in culture tanks and fed a 35% protein feed plus an additional supplementation of three dietary oils (20% each of coconut oil, palm oil, or cod liver oil). Body weight gain was similar among all groups. However, several hepatic lipogenic enzymes such as malic enzyme (ME), NADP-isocitrate dehydrogenase (ICDH), glucose 6-phosphate dehydrogenase (G6PDH), 6-phosphogluconate dehydrogenase (6PGDH) and beta-hydroxy-1-methyl glutaryl CoA reductase (HMG CoA reductase) were assayed, and they responded differently. Hepatic ME and G6PDH activities showed a significant decrease in the coconut oil and palm oil groups, but there was no significant change in ICDH activity. The 6PGDH activities were reduced, whereas HMG CoA reductase activity was increased in the palm oil-treated group. Cholesterol synthesis in the liver and muscle increased in the palm oil-treated group, but liver phospholipids did not show any significant change in fish supplemented with oils rich in saturated fatty acids. Triacylglycerol and free fatty acid concentrations were high in the coconut oil- and palm oil-supplemented groups. Lipid peroxidation products such as thiobarbituric acid-reactive substances and conjugated dienes decreased in the same two groups. Antioxidant potential was high in all groups as evidenced by increased activity of superoxide dismutase, glutathione peroxidase, and glutathione content. The results of this study indicate that in fish, dietary lipids depress hepatic lipogenic activity as well as lipid peroxidation products by maintaining high levels of antioxidant enzymes. SN - 0024-4201 UR - https://www.unboundmedicine.com/medline/citation/10941876/Long_term_feeding_of_dietary_oils_alters_lipid_metabolism_lipid_peroxidation_and_antioxidant_enzyme_activities_in_a_teleost__Anabas_testudineus_Bloch__ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0024-4201&date=2000&volume=35&issue=7&spage=757 DB - PRIME DP - Unbound Medicine ER -