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Cold shock response in mammalian cells.
J Mol Microbiol Biotechnol. 1999 Nov; 1(2):243-55.JM

Abstract

Compared to bacteria and plants, the cold shock response has attracted little attention in mammals except in some areas such as adaptive thermogenesis, cold tolerance, storage of cells and organs, and recently, treatment of brain damage and protein production. At the cellular level, some responses of mammalian cells are similar to microorganisms; cold stress changes the lipid composition of cellular membranes, and suppresses the rate of protein synthesis and cell proliferation. Although previous studies have mostly dealt with temperatures below 20 degrees C, mild hypothermia (32 degrees C) can change the cell's response to subsequent stresses as exemplified by APG-1, a member of the HSP110 family. Furthermore, 32 degrees C induces expression of CIRP (cold-inducible RNA-binding protein), the first cold shock protein identified in mammalian cells, without recovery at 37 degrees C. Remniscent of HSP, CIRP is also expressed at 37 degrees C and developmentary regulated, possibly working as an RNA chaperone. Mammalian cells are metabolically active at 32 degrees C, and cells may survive and respond to stresses with different strategies from those at 37 degrees C. Cellular and molecular biology of mammalian cells at 32 degrees C is a new area expected to have considerable implications for medical sciences and possibly biotechnology.

Authors+Show Affiliations

Fujita J
Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Japan. jfujita@virus.kyoto-u.ac.jp

MeSH

Adaptation, PhysiologicalAmino Acid SequenceAnimalsCold TemperatureHeat-Shock ResponseHumansMammalsMolecular Sequence DataRNA-Binding Proteins

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10943555

Citation

Fujita, J. "Cold Shock Response in Mammalian Cells." Journal of Molecular Microbiology and Biotechnology, vol. 1, no. 2, 1999, pp. 243-55.
Fujita J. Cold shock response in mammalian cells. J Mol Microbiol Biotechnol. 1999;1(2):243-55.
Fujita, J. (1999). Cold shock response in mammalian cells. Journal of Molecular Microbiology and Biotechnology, 1(2), 243-55.
Fujita J. Cold Shock Response in Mammalian Cells. J Mol Microbiol Biotechnol. 1999;1(2):243-55. PubMed PMID: 10943555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cold shock response in mammalian cells. A1 - Fujita,J, PY - 2000/8/16/pubmed PY - 2000/9/19/medline PY - 2000/8/16/entrez SP - 243 EP - 55 JF - Journal of molecular microbiology and biotechnology JO - J Mol Microbiol Biotechnol VL - 1 IS - 2 N2 - Compared to bacteria and plants, the cold shock response has attracted little attention in mammals except in some areas such as adaptive thermogenesis, cold tolerance, storage of cells and organs, and recently, treatment of brain damage and protein production. At the cellular level, some responses of mammalian cells are similar to microorganisms; cold stress changes the lipid composition of cellular membranes, and suppresses the rate of protein synthesis and cell proliferation. Although previous studies have mostly dealt with temperatures below 20 degrees C, mild hypothermia (32 degrees C) can change the cell's response to subsequent stresses as exemplified by APG-1, a member of the HSP110 family. Furthermore, 32 degrees C induces expression of CIRP (cold-inducible RNA-binding protein), the first cold shock protein identified in mammalian cells, without recovery at 37 degrees C. Remniscent of HSP, CIRP is also expressed at 37 degrees C and developmentary regulated, possibly working as an RNA chaperone. Mammalian cells are metabolically active at 32 degrees C, and cells may survive and respond to stresses with different strategies from those at 37 degrees C. Cellular and molecular biology of mammalian cells at 32 degrees C is a new area expected to have considerable implications for medical sciences and possibly biotechnology. SN - 1464-1801 UR - https://www.unboundmedicine.com/medline/citation/10943555/Cold_shock_response_in_mammalian_cells_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:10943555 DB - PRIME DP - Unbound Medicine ER -