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Expression of interleukin-2 receptor by activated peripheral blood lymphocytes upregulated by the plasma level of interleukin-2 in patients with recurrent aphthous ulcers.
Proc Natl Sci Counc Repub China B. 2000 Jul; 24(3):116-22.PN

Abstract

This study used flow cytometry to determine the peripheral blood lymphocyte subsets and a sandwich enzyme immunoassay to measure the plasma levels of interleukin-2 (IL-2) and soluble IL-2 receptor (sIL-2R) in 34 patients in different stages of recurrent aphthous ulcers (RAU) and in 32 age/sex-matched normal control subjects. In the exacerbation stage of RAU, a significant increase in the percentages of CD3+ (p < 0.001), CD4+ (p < 0.001), CD4+ IL-2R+ (p < 0.001), CD8+ IL-2R+ (p < 0.01) and IL-2R+ cells (p < 0.001), in the CD4+/CD8+ (p < 0.01) and CD4+/CD3+ CD8+ ratios (p < 0.01), and in the plasma level of IL-2 (p < 0.001) was found in the patients as compared with the levels in the normal control subjects. However, in the post-exacerbation stage of RAU, there was a significant decrease in the percentage of CD4+ cells (p < 0.05) and in the CD4+/CD8+ (p < 0.01) and CD4+/CD3+ CD8+ ratios (p < 0.001), as well as a significant increase in CD8+ cells (p < 0.001) in the patients, as compared with the levels in the normal control subjects. Because the CD4+, CD4+ IL-2R+ and CD8+ IL-2R+ cell counts and the plasma level of IL-2 increased simultaneously in the patients in the exacerbation stage of RAU, we suggest that the markedly increased plasma level of IL-2 may have been secreted by the increased number of activated CD4+ cells, and that the expression of IL-2R by activated peripheral blood lymphocytes was upregulated by the plasma level of IL-2 in patients with RAU. In addition, the increase and then decrease of the CD4+/CD8+ ratio in the RAU patients and the increased number of CD4+ IL-2R+ and CD8+ IL-2R+ activated T cells in the RAU patients support the role of cell-mediated cytotoxicity in the immunopathogenesis of RAU.

Authors+Show Affiliations

School of Dentistry, College of Medicine, National Taiwan University, Taipei, ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10943944

Citation

Sun, A, et al. "Expression of Interleukin-2 Receptor By Activated Peripheral Blood Lymphocytes Upregulated By the Plasma Level of Interleukin-2 in Patients With Recurrent Aphthous Ulcers." Proceedings of the National Science Council, Republic of China. Part B, Life Sciences, vol. 24, no. 3, 2000, pp. 116-22.
Sun A, Chu CT, Liu BY, et al. Expression of interleukin-2 receptor by activated peripheral blood lymphocytes upregulated by the plasma level of interleukin-2 in patients with recurrent aphthous ulcers. Proc Natl Sci Counc Repub China B. 2000;24(3):116-22.
Sun, A., Chu, C. T., Liu, B. Y., Wang, J. T., Leu, J. S., & Chiang, C. P. (2000). Expression of interleukin-2 receptor by activated peripheral blood lymphocytes upregulated by the plasma level of interleukin-2 in patients with recurrent aphthous ulcers. Proceedings of the National Science Council, Republic of China. Part B, Life Sciences, 24(3), 116-22.
Sun A, et al. Expression of Interleukin-2 Receptor By Activated Peripheral Blood Lymphocytes Upregulated By the Plasma Level of Interleukin-2 in Patients With Recurrent Aphthous Ulcers. Proc Natl Sci Counc Repub China B. 2000;24(3):116-22. PubMed PMID: 10943944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of interleukin-2 receptor by activated peripheral blood lymphocytes upregulated by the plasma level of interleukin-2 in patients with recurrent aphthous ulcers. AU - Sun,A, AU - Chu,C T, AU - Liu,B Y, AU - Wang,J T, AU - Leu,J S, AU - Chiang,C P, PY - 2000/8/16/pubmed PY - 2001/2/28/medline PY - 2000/8/16/entrez SP - 116 EP - 22 JF - Proceedings of the National Science Council, Republic of China. Part B, Life sciences JO - Proc Natl Sci Counc Repub China B VL - 24 IS - 3 N2 - This study used flow cytometry to determine the peripheral blood lymphocyte subsets and a sandwich enzyme immunoassay to measure the plasma levels of interleukin-2 (IL-2) and soluble IL-2 receptor (sIL-2R) in 34 patients in different stages of recurrent aphthous ulcers (RAU) and in 32 age/sex-matched normal control subjects. In the exacerbation stage of RAU, a significant increase in the percentages of CD3+ (p < 0.001), CD4+ (p < 0.001), CD4+ IL-2R+ (p < 0.001), CD8+ IL-2R+ (p < 0.01) and IL-2R+ cells (p < 0.001), in the CD4+/CD8+ (p < 0.01) and CD4+/CD3+ CD8+ ratios (p < 0.01), and in the plasma level of IL-2 (p < 0.001) was found in the patients as compared with the levels in the normal control subjects. However, in the post-exacerbation stage of RAU, there was a significant decrease in the percentage of CD4+ cells (p < 0.05) and in the CD4+/CD8+ (p < 0.01) and CD4+/CD3+ CD8+ ratios (p < 0.001), as well as a significant increase in CD8+ cells (p < 0.001) in the patients, as compared with the levels in the normal control subjects. Because the CD4+, CD4+ IL-2R+ and CD8+ IL-2R+ cell counts and the plasma level of IL-2 increased simultaneously in the patients in the exacerbation stage of RAU, we suggest that the markedly increased plasma level of IL-2 may have been secreted by the increased number of activated CD4+ cells, and that the expression of IL-2R by activated peripheral blood lymphocytes was upregulated by the plasma level of IL-2 in patients with RAU. In addition, the increase and then decrease of the CD4+/CD8+ ratio in the RAU patients and the increased number of CD4+ IL-2R+ and CD8+ IL-2R+ activated T cells in the RAU patients support the role of cell-mediated cytotoxicity in the immunopathogenesis of RAU. SN - 0255-6596 UR - https://www.unboundmedicine.com/medline/citation/10943944/Expression_of_interleukin_2_receptor_by_activated_peripheral_blood_lymphocytes_upregulated_by_the_plasma_level_of_interleukin_2_in_patients_with_recurrent_aphthous_ulcers_ L2 - https://medlineplus.gov/cankersores.html DB - PRIME DP - Unbound Medicine ER -