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Micronutrients and innate immunity.
J Infect Dis 2000; 182 Suppl 1:S5-10JI

Abstract

Micronutrients such as zinc, selenium, iron, copper, beta-carotene, vitamins A, C, and E, and folic acid can influence several components of innate immunity. Select micronutrients play an important role in alteration of oxidant-mediated tissue injury, and phagocytic cells produce reactive oxidants as part of the defense against infectious agents. Thus, adequate micronutrients are required to prevent damage of cells participating in innate immunity. Deficiencies in zinc and vitamins A and D may reduce natural killer cell function, whereas supplemental zinc or vitamin C may enhance their activity. The specific effects of micronutrients on neutrophil functions are not clear. Select micronutrients may play a role in innate immunity associated with some disease processes. Future studies should focus on issues such as age-related micronutrient status and innate immunity, alterations of micronutrients in disease states and their effect on innate immunity, and the mechanisms by which micronutrients alter innate immunity.

Authors+Show Affiliations

Department of Cell Biology and Human Anatomy, University of California, School of Medicine, Davis, CA 95616-8643, USA. klerickson@ucdavis.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10944478

Citation

Erickson, K L., et al. "Micronutrients and Innate Immunity." The Journal of Infectious Diseases, vol. 182 Suppl 1, 2000, pp. S5-10.
Erickson KL, Medina EA, Hubbard NE. Micronutrients and innate immunity. J Infect Dis. 2000;182 Suppl 1:S5-10.
Erickson, K. L., Medina, E. A., & Hubbard, N. E. (2000). Micronutrients and innate immunity. The Journal of Infectious Diseases, 182 Suppl 1, pp. S5-10.
Erickson KL, Medina EA, Hubbard NE. Micronutrients and Innate Immunity. J Infect Dis. 2000;182 Suppl 1:S5-10. PubMed PMID: 10944478.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Micronutrients and innate immunity. AU - Erickson,K L, AU - Medina,E A, AU - Hubbard,N E, PY - 2000/8/17/pubmed PY - 2000/10/21/medline PY - 2000/8/17/entrez SP - S5 EP - 10 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 182 Suppl 1 N2 - Micronutrients such as zinc, selenium, iron, copper, beta-carotene, vitamins A, C, and E, and folic acid can influence several components of innate immunity. Select micronutrients play an important role in alteration of oxidant-mediated tissue injury, and phagocytic cells produce reactive oxidants as part of the defense against infectious agents. Thus, adequate micronutrients are required to prevent damage of cells participating in innate immunity. Deficiencies in zinc and vitamins A and D may reduce natural killer cell function, whereas supplemental zinc or vitamin C may enhance their activity. The specific effects of micronutrients on neutrophil functions are not clear. Select micronutrients may play a role in innate immunity associated with some disease processes. Future studies should focus on issues such as age-related micronutrient status and innate immunity, alterations of micronutrients in disease states and their effect on innate immunity, and the mechanisms by which micronutrients alter innate immunity. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/10944478/Micronutrients_and_innate_immunity_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/315922 DB - PRIME DP - Unbound Medicine ER -