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Low levels of high density lipoproteins in Turks, a population with elevated hepatic lipase. High density lipoprotein characterization and gender-specific effects of apolipoprotein e genotype.
J Lipid Res. 2000 Aug; 41(8):1290-301.JL

Abstract

Turks have strikingly low levels of high density lipoprotein cholesterol (HDL-C) (10-15 mg/dL lower than those of Americans or Western Europeans) associated with elevated hepatic lipase mass and activity. Here we report that Turks have low levels of high density lipoprotein subclass 2 (HDL(2)), apoA-I-containing lipoproteins (LpA-I), and pre-beta-1 HDL and increased levels of HDL(3) and LpA-I/A-II particles (potentially an atherogenic lipid profile). The frequency distributions of HDL-C and LpA-I levels were skewed toward bimodality in Turkish women but were unimodal in Turkish men. The apoE genotype affected HDL-C and LpA-I levels in women only. In women, but not men, the varepsilon2 allele was strikingly more prevalent in those with the highest levels of HDL-C and LpA-I than in those with the lowest levels. The higher prevalence of the epsilon2 allele in these subgroups of women was not explained by plasma triglyceride levels, total cholesterol levels, age, or body mass index. The modulating effects of apoE isoforms on lipolytic hydrolysis of HDL by hepatic lipase (apoE2 preventing efficient hydrolysis) or on lipoprotein receptor binding (apoE2 interacting poorly with the low density lipoprotein receptors) may account for differences in HDL-C levels in Turkish women (the epsilon2 allele being associated with higher HDL levels). In Turkish men, who have substantially higher levels of hepatic lipase activity than women, the modulating effect of apoE may be overwhelmed. The gender-specific impact of the apoE genotype on HDL-C and LpA-I levels in association with elevated levels of hepatic lipase provides new insights into the metabolism of HDL.

Authors+Show Affiliations

Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10946017

Citation

Mahley, R W., et al. "Low Levels of High Density Lipoproteins in Turks, a Population With Elevated Hepatic Lipase. High Density Lipoprotein Characterization and Gender-specific Effects of Apolipoprotein E Genotype." Journal of Lipid Research, vol. 41, no. 8, 2000, pp. 1290-301.
Mahley RW, Pépin J, Palaoğlu KE, et al. Low levels of high density lipoproteins in Turks, a population with elevated hepatic lipase. High density lipoprotein characterization and gender-specific effects of apolipoprotein e genotype. J Lipid Res. 2000;41(8):1290-301.
Mahley, R. W., Pépin, J., Palaoğlu, K. E., Malloy, M. J., Kane, J. P., & Bersot, T. P. (2000). Low levels of high density lipoproteins in Turks, a population with elevated hepatic lipase. High density lipoprotein characterization and gender-specific effects of apolipoprotein e genotype. Journal of Lipid Research, 41(8), 1290-301.
Mahley RW, et al. Low Levels of High Density Lipoproteins in Turks, a Population With Elevated Hepatic Lipase. High Density Lipoprotein Characterization and Gender-specific Effects of Apolipoprotein E Genotype. J Lipid Res. 2000;41(8):1290-301. PubMed PMID: 10946017.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low levels of high density lipoproteins in Turks, a population with elevated hepatic lipase. High density lipoprotein characterization and gender-specific effects of apolipoprotein e genotype. AU - Mahley,R W, AU - Pépin,J, AU - Palaoğlu,K E, AU - Malloy,M J, AU - Kane,J P, AU - Bersot,T P, PY - 2000/8/18/pubmed PY - 2000/10/14/medline PY - 2000/8/18/entrez SP - 1290 EP - 301 JF - Journal of lipid research JO - J Lipid Res VL - 41 IS - 8 N2 - Turks have strikingly low levels of high density lipoprotein cholesterol (HDL-C) (10-15 mg/dL lower than those of Americans or Western Europeans) associated with elevated hepatic lipase mass and activity. Here we report that Turks have low levels of high density lipoprotein subclass 2 (HDL(2)), apoA-I-containing lipoproteins (LpA-I), and pre-beta-1 HDL and increased levels of HDL(3) and LpA-I/A-II particles (potentially an atherogenic lipid profile). The frequency distributions of HDL-C and LpA-I levels were skewed toward bimodality in Turkish women but were unimodal in Turkish men. The apoE genotype affected HDL-C and LpA-I levels in women only. In women, but not men, the varepsilon2 allele was strikingly more prevalent in those with the highest levels of HDL-C and LpA-I than in those with the lowest levels. The higher prevalence of the epsilon2 allele in these subgroups of women was not explained by plasma triglyceride levels, total cholesterol levels, age, or body mass index. The modulating effects of apoE isoforms on lipolytic hydrolysis of HDL by hepatic lipase (apoE2 preventing efficient hydrolysis) or on lipoprotein receptor binding (apoE2 interacting poorly with the low density lipoprotein receptors) may account for differences in HDL-C levels in Turkish women (the epsilon2 allele being associated with higher HDL levels). In Turkish men, who have substantially higher levels of hepatic lipase activity than women, the modulating effect of apoE may be overwhelmed. The gender-specific impact of the apoE genotype on HDL-C and LpA-I levels in association with elevated levels of hepatic lipase provides new insights into the metabolism of HDL. SN - 0022-2275 UR - https://www.unboundmedicine.com/medline/citation/10946017/Low_levels_of_high_density_lipoproteins_in_Turks_a_population_with_elevated_hepatic_lipase__High_density_lipoprotein_characterization_and_gender_specific_effects_of_apolipoprotein_e_genotype_ L2 - http://www.jlr.org/cgi/pmidlookup?view=long&pmid=10946017 DB - PRIME DP - Unbound Medicine ER -