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Copper and zinc concentrations and the activities of ceruloplasmin and superoxide dismutase in atherosclerosis obliterans.
Biol Trace Elem Res 2000; 73(1):55-65BT

Abstract

The relationships among concentrations of copper and zinc, the oxidase activity of ceruloplasmin (Cp) in serum, and Cu,Zn-SOD (superoxide dismutase) activity in erythrocytes were investigated in men with atherosclerosis obliterans (AO) and a control group. The oxidase activity of Cp was measured with o-dianisidine dihydrochloride as a substrate, and Cu,Zn-SOD activity in erythrocytes by using the RANSOD kit. The lipid profile and uric acid concentration were determined in AO and control groups. The results showed higher copper and zinc concentrations in serum in the AO group (20.0+/-3.5 and 18.0+/-3.2 micromol/L, respectively) in comparison with the control group (15.6+/-2.3 and 14.7+/-1.9 micromol/L). The Cp activity in serum was higher in the AO group (174.2+/-61.8 U/L) than in the control group (93.7+/-33.9 U/L), and a significant difference was found in the activity of Cu,Zn-SOD in erythrocytes (2389+/-1396 and 1245+/-365 U/g Hb, respectively) between both groups. The activity of Cu,Zn-SOD was positively correlated with copper in the control group (r=0.73), but not in AO, and negatively with uric acid concentration (r= -0.63) in the AO group. The oxidase activity of Cp was correlated with copper, but not zinc, in AO and control groups (r> or =0.65). Negative correlation coefficients were calculated for uric acid and copper and zinc concentrations in the AO group (-r > or = 0.61). Increased copper concentrations and oxidase activity of Cp in serum in AO and the activity of Cu,Zn-SOD in erythrocytes could result from atherosclerotic disease, accompanied by chronic ischemia of a lower limb. These results suggest also that relationship between copper concentration and Cu,Zn-SOD activity in erythrocytes found in the serum of healthy subjects may be disturbed in pathologic conditions.

Authors+Show Affiliations

Department of General Chemistry, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10949969

Citation

Iskra, M, and W Majewski. "Copper and Zinc Concentrations and the Activities of Ceruloplasmin and Superoxide Dismutase in Atherosclerosis Obliterans." Biological Trace Element Research, vol. 73, no. 1, 2000, pp. 55-65.
Iskra M, Majewski W. Copper and zinc concentrations and the activities of ceruloplasmin and superoxide dismutase in atherosclerosis obliterans. Biol Trace Elem Res. 2000;73(1):55-65.
Iskra, M., & Majewski, W. (2000). Copper and zinc concentrations and the activities of ceruloplasmin and superoxide dismutase in atherosclerosis obliterans. Biological Trace Element Research, 73(1), pp. 55-65.
Iskra M, Majewski W. Copper and Zinc Concentrations and the Activities of Ceruloplasmin and Superoxide Dismutase in Atherosclerosis Obliterans. Biol Trace Elem Res. 2000;73(1):55-65. PubMed PMID: 10949969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Copper and zinc concentrations and the activities of ceruloplasmin and superoxide dismutase in atherosclerosis obliterans. AU - Iskra,M, AU - Majewski,W, PY - 1998/10/16/received PY - 1999/01/17/revised PY - 1999/03/01/accepted PY - 2000/8/19/pubmed PY - 2001/2/28/medline PY - 2000/8/19/entrez SP - 55 EP - 65 JF - Biological trace element research JO - Biol Trace Elem Res VL - 73 IS - 1 N2 - The relationships among concentrations of copper and zinc, the oxidase activity of ceruloplasmin (Cp) in serum, and Cu,Zn-SOD (superoxide dismutase) activity in erythrocytes were investigated in men with atherosclerosis obliterans (AO) and a control group. The oxidase activity of Cp was measured with o-dianisidine dihydrochloride as a substrate, and Cu,Zn-SOD activity in erythrocytes by using the RANSOD kit. The lipid profile and uric acid concentration were determined in AO and control groups. The results showed higher copper and zinc concentrations in serum in the AO group (20.0+/-3.5 and 18.0+/-3.2 micromol/L, respectively) in comparison with the control group (15.6+/-2.3 and 14.7+/-1.9 micromol/L). The Cp activity in serum was higher in the AO group (174.2+/-61.8 U/L) than in the control group (93.7+/-33.9 U/L), and a significant difference was found in the activity of Cu,Zn-SOD in erythrocytes (2389+/-1396 and 1245+/-365 U/g Hb, respectively) between both groups. The activity of Cu,Zn-SOD was positively correlated with copper in the control group (r=0.73), but not in AO, and negatively with uric acid concentration (r= -0.63) in the AO group. The oxidase activity of Cp was correlated with copper, but not zinc, in AO and control groups (r> or =0.65). Negative correlation coefficients were calculated for uric acid and copper and zinc concentrations in the AO group (-r > or = 0.61). Increased copper concentrations and oxidase activity of Cp in serum in AO and the activity of Cu,Zn-SOD in erythrocytes could result from atherosclerotic disease, accompanied by chronic ischemia of a lower limb. These results suggest also that relationship between copper concentration and Cu,Zn-SOD activity in erythrocytes found in the serum of healthy subjects may be disturbed in pathologic conditions. SN - 0163-4984 UR - https://www.unboundmedicine.com/medline/citation/10949969/Copper_and_zinc_concentrations_and_the_activities_of_ceruloplasmin_and_superoxide_dismutase_in_atherosclerosis_obliterans_ L2 - https://dx.doi.org/10.1385/BTER:73:1:55 DB - PRIME DP - Unbound Medicine ER -